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  1. Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer’s disease (AD). We have recen...

    Authors: Michelle A Erickson, Pehr E Hartvigson, Yoichi Morofuji, Joshua B Owen, D Allan Butterfield and William A Banks
    Citation: Journal of Neuroinflammation 2012 9:150
  2. Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of urokinase type plasminogen activators (uPA) and tissue type plasminogen activators (tPA), which mediate fibrinolysis. PAI-1 is also in...

    Authors: Hyejin Jeon, Jong-Heon Kim, Jae-Hong Kim, Won-Ha Lee, Myung-Shik Lee and Kyoungho Suk
    Citation: Journal of Neuroinflammation 2012 9:149
  3. Phosphatidylserine receptor is a key molecule that mediates the phagocytosis of apoptotic cells. Milk fat globule-EGF factor 8 (MFG-E8) is a phosphatidylserine receptor that is expressed on various macrophage ...

    Authors: Endong Li, Mariko Noda, Yukiko Doi, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno and Akio Suzumura
    Citation: Journal of Neuroinflammation 2012 9:148
  4. Systemic infection leads to generation of inflammatory mediators that result in metabolic and behavioural changes. Repeated or chronic systemic inflammation leads to a state of innate immune tolerance: a prote...

    Authors: Ursula Püntener, Steven G Booth, V Hugh Perry and Jessica L Teeling
    Citation: Journal of Neuroinflammation 2012 9:146
  5. Transforming growth factor-β1 (TGF-β1) is an important regulator of cell migration and plays a role in the scarring response in injured brain. It is also reported that 5-lipoxygenase (5-LOX) and its products, ...

    Authors: Xue-Qin Huang, Xia-Yan Zhang, Xiao-Rong Wang, Shu-Ying Yu, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang and Er-Qing Wei
    Citation: Journal of Neuroinflammation 2012 9:145
  6. In immune-mediated diseases of the central nervous system, astrocytes exposed to interferon-γ (IFN-γ) can express major histocompatibility complex (MHC) class II molecules and antigens on their surface. MHC cl...

    Authors: Nina Vardjan, Mateja Gabrijel, Maja Potokar, Urban Švajger, Marko Kreft, Matjaž Jeras, Yolanda de Pablo, Maryam Faiz, Milos Pekny and Robert Zorec
    Citation: Journal of Neuroinflammation 2012 9:144
  7. Chronic pain is often associated with microglia activation in the spinal cord. We recently showed that microglial levels of the kinase G protein–coupled receptor kinase (GRK)2 are reduced in models of chronic ...

    Authors: Hanneke LDM Willemen, Xiao-Jiao Huo, Qi-Liang Mao-Ying, Jitske Zijlstra, Cobi J Heijnen and Annemieke Kavelaars
    Citation: Journal of Neuroinflammation 2012 9:143
  8. Activated microglia exerts both beneficial and deleterious effects on neurons, but the signaling mechanism controlling these distinct responses remain unclear. We demonstrated that treatment of microglial cult...

    Authors: Chen-wen Chen, Qian-bo Chen, Qing Ouyang, Ji-hu Sun, Fang-ting Liu, Dian-wen Song and Hong-bin Yuan
    Citation: Journal of Neuroinflammation 2012 9:142
  9. A subset of patients with multiple sclerosis (MS) shows an increased endogenous IFN-like activity before initiation of IFN-beta treatment. The molecular basis of this phenomenon and its relevance to predict in...

    Authors: Alexander Hundeshagen, Michael Hecker, Brigitte Katrin Paap, Charlotte Angerstein, Ole Kandulski, Christian Fatum, Christiane Hartmann, Dirk Koczan, Hans-Juergen Thiesen and Uwe Klaus Zettl
    Citation: Journal of Neuroinflammation 2012 9:140
  10. DNA vaccines represent promising therapeutic strategies in autoimmune disorders such as multiple sclerosis (MS). However, the precise mechanisms by which DNA vaccines induce immune regulation remain largely un...

    Authors: Nicolás Fissolo, Carme Costa, Ramil N Nurtdinov, Marta F Bustamante, Victor Llombart, María J Mansilla, Carmen Espejo, Xavier Montalban and Manuel Comabella
    Citation: Journal of Neuroinflammation 2012 9:139
  11. Human immunodeficiency virus type 1 (HIV-1) induces neuronal dysfunction through host cellular factors and viral proteins including viral protein R (Vpr) released from infected macrophages/microglia. Vpr is im...

    Authors: Debjani Guha, Pruthvi Nagilla, Carrie Redinger, Alagarsamy Srinivasan, Gerald P Schatten and Velpandi Ayyavoo
    Citation: Journal of Neuroinflammation 2012 9:138
  12. The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. The awareness that immunological mediators support vari...

    Authors: Faith H Brennan, Aileen J Anderson, Stephen M Taylor, Trent M Woodruff and Marc J Ruitenberg
    Citation: Journal of Neuroinflammation 2012 9:137
  13. Spinal cord injury (SCI) is a devastating condition with substantial functional and social morbidity. Previous research has established that the neuroinflammatory response plays a significant role in cord dama...

    Authors: Newton Cho, Dung H Nguyen, Kajana Satkunendrarajah, Donald R Branch and Michael G Fehlings
    Citation: Journal of Neuroinflammation 2012 9:134
  14. The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has...

    Authors: Ruben van Doorn, Melissa A Lopes Pinheiro, Gijs Kooij, Kim Lakeman, Bert van het Hof, Susanne MA van der Pol, Dirk Geerts, Jack van Horssen, Paul van der Valk, Elizabeth van der Kam, Eric Ronken, Arie Reijerkerk and Helga E de Vries
    Citation: Journal of Neuroinflammation 2012 9:133
  15. Aging and atherosclerosis are well-recognized risk factors for cardiac and neurovascular diseases. The Apolipoprotein E deficient (ApoE−/−) mouse on a high-fat diet is a classical model of atherosclerosis, cha...

    Authors: Jérôme Badaut, Jean-Christophe Copin, Andrew M Fukuda, Yvan Gasche, Karl Schaller and Rafaela F da Silva
    Citation: Journal of Neuroinflammation 2012 9:132
  16. HIV-1 Tat protein is known to be associated with neuroinflammation, a condition that develops in almost half of patients infected with HIV-1. HIV-1 Tat can alter glial neuroprotective functions, leading to neu...

    Authors: Ritu Mishra, Chintan Chhatbar and Sunit Kumar Singh
    Citation: Journal of Neuroinflammation 2012 9:131
  17. Interferon-beta (IFNB) therapy for multiple sclerosis can lead to the induction of neutralizing antibodies (NAbs) against IFNB. Various methods are used for detection and quantification of NAbs.

    Authors: Hans-Peter Hartung, Bernd Kieseier, Douglas S Goodin, Barry GW Arnason, Giancarlo Comi, Stuart Cook, Massimo Filippi, Douglas R Jeffery, Ludwig Kappos, Timon Bogumil, Brigitte Stemper, Rupert Sandbrink, Yukiko Nakada, Haruhiko Nakajima, Susanne Schwenke, Stephan Lehr…
    Citation: Journal of Neuroinflammation 2012 9:129
  18. Although IL-17A (commonly referred to as IL-17) has been implicated in the pathogenesis of central nervous system (CNS) autoimmune disease, its role during CNS bacterial infections remains unclear. To evaluate...

    Authors: Debbie Vidlak and Tammy Kielian
    Citation: Journal of Neuroinflammation 2012 9:128
  19. The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons...

    Authors: Qingshan Wang, Eun-Joo Shin, Xuan-Khanh Thi Nguyen, Quan Li, Jae-Hyung Bach, Guoying Bing, Won-Ki Kim, Hyoung-Chun Kim and Jau-Shyong Hong
    Citation: Journal of Neuroinflammation 2012 9:124
  20. Gold nanoparticles (AuNPs) are finding increased use in therapeutics and imaging. However, their toxic effects still remain to be elucidated. Therefore this study was undertaken to study the biochemical effect...

    Authors: Nikhat J Siddiqi, Mohamed Anwar K Abdelhalim, Afaf K El-Ansary, Abdullah S Alhomida and W Y Ong
    Citation: Journal of Neuroinflammation 2012 9:123
  21. A variety of methods have been used to study inflammatory changes in the acutely injured spinal cord. Recently novel multiplex assays have been used in an attempt to overcome limitations in numbers of availabl...

    Authors: Matthew Light, Kenneth H Minor, Peter DeWitt, Kyle H Jasper and Stephen JA Davies
    Citation: Journal of Neuroinflammation 2012 9:122
  22. Nogo-A is a member of the reticulon family of membrane-associated proteins and plays an important role in axonal remodeling. The present study aimed to investigate alterations in Nogo-A expression following tr...

    Authors: Po-Kuan Chao, Kwok-Tung Lu, Ji-Yi Jhu, Yu-Yuan Peter Wo, Tai-Chun Huang, Long-Sun Ro and Yi-Ling Yang
    Citation: Journal of Neuroinflammation 2012 9:121
  23. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by damage to the neuronal myelin sheath. One of the key effectors for inflammatory injury is the antigen-prese...

    Authors: Hilit Levy-Barazany and Dan Frenkel
    Citation: Journal of Neuroinflammation 2012 9:120
  24. The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath. The resulting electrical instability of Aβ-fib...

    Authors: Huaqing Liu, Sergey A Shiryaev, Andrei V Chernov, Youngsoon Kim, Igor Shubayev, Albert G Remacle, Svetlana Baranovskaya, Vladislav S Golubkov, Alex Y Strongin and Veronica I Shubayev
    Citation: Journal of Neuroinflammation 2012 9:119
  25. Correction to Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti...

    Authors: Konstantin Dirscherl, Marcus Karlstetter, Stefanie Ebert, Dominik Kraus, Julia Hlawatsch, Yana Walczak, Christoph Moehle, Rudolf Fuchshofer and Thomas Langmann
    Citation: Journal of Neuroinflammation 2012 9:118

    The original article was published in Journal of Neuroinflammation 2010 7:3

  26. There is increasing interest in astrocyte biology because astrocytes have been demonstrated to play prominent roles in physiological and pathological conditions of the central nervous system, including neuroin...

    Authors: Hiromi Kumamaru, Hirokazu Saiwai, Kazu Kobayakawa, Kensuke Kubota, Nico van Rooijen, Kazuhide Inoue, Yukihide Iwamoto and Seiji Okada
    Citation: Journal of Neuroinflammation 2012 9:116
  27. For successful translation to clinical stroke studies, the Stroke Therapy Academic Industry Round Table criteria have been proposed. Two important criteria are testing of therapeutic interventions in conscious...

    Authors: Deborah De Geyter, Wendy Stoop, Tine Zgavc, Sophie Sarre, Yvette Michotte, Jacques De Keyser and Ron Kooijman
    Citation: Journal of Neuroinflammation 2012 9:114
  28. Increasing evidence shows that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) possesses potent anti-inflammatory and immunomodulatory properties. It is tempting to evaluate the potent...

    Authors: Sadayuki Hashioka, Andis Klegeris and Patrick L McGeer
    Citation: Journal of Neuroinflammation 2012 9:113
  29. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T regulatory (Treg) cell therapy has proved to b...

    Authors: Moa Fransson, Elena Piras, Joachim Burman, Berith Nilsson, Magnus Essand, BinFeng Lu, Robert A Harris, Peetra U Magnusson, Eva Brittebo and Angelica SI Loskog
    Citation: Journal of Neuroinflammation 2012 9:112
  30. WNT-5A signaling in the central nervous system is important for morphogenesis, neurogenesis and establishment of functional connectivity; the source of WNT-5A and its importance for cellular communication in t...

    Authors: Carina Halleskog, Jacomijn Petronella Dijksterhuis, Michaela Brita Christina Kilander, Javier Becerril-Ortega, Juan Carlos Villaescusa, Eva Lindgren, Ernest Arenas and Gunnar Schulte
    Citation: Journal of Neuroinflammation 2012 9:111
  31. The primary olfactory pathway is a potential route through which microorganisms from the periphery could potentially access the central nervous system. Our previous studies demonstrated that if the olfactory e...

    Authors: Rosalind P Herbert, Julie Harris, Kim Pei Chong, Jamie Chapman, Adrian K West and Meng Inn Chuah
    Citation: Journal of Neuroinflammation 2012 9:109
  32. Prokineticin 2 (PK2) is a secreted protein and causes potent hyperalgesia in vivo, and is therefore considered to be a new pronociceptive mediator. However, the molecular targets responsible for the pronocicep...

    Authors: Chun-Yu Qiu, Yu-Qiang Liu, Fang Qiu, Jiliang Wu, Qun-Yong Zhou and Wang-Ping Hu
    Citation: Journal of Neuroinflammation 2012 9:108
  33. The interaction between the membrane glycoprotein, CD200 and its cognate receptor CD200 receptor (CD200R), has been shown to play a role in maintaining microglia in a quiescent state. There is evidence of incr...

    Authors: Anthony Lyons, Eric J Downer, Derek A Costello, Niamh Murphy and Marina A Lynch
    Citation: Journal of Neuroinflammation 2012 9:107
  34. Neuroinflammation is associated with virtually all major neurodegenerative disorders, including Alzheimer’s disease (AD). Although it remains unclear whether neuroinflammation is the driving force behind these...

    Authors: David Tweedie, Ryan A Ferguson, Kelly Fishman, Kathryn A Frankola, Henriette Van Praag, Harold W Holloway, Weiming Luo, Yazhou Li, Luca Caracciolo, Isabella Russo, Sergio Barlati, Balmiki Ray, Debomoy K Lahiri, Francesca Bosetti, Nigel H Greig and Susanna Rosi
    Citation: Journal of Neuroinflammation 2012 9:106
  35. Human intravenous immunoglobulin (hIVIG) preparation is indicated for treating primary immunodeficiency disorders associated with impaired humoral immunity. hIVIG is known for its anti-inflammatory properties ...

    Authors: Lakshman Puli, Yuriy Pomeshchik, Katja Olas, Tarja Malm, Jari Koistinaho and Heikki Tanila
    Citation: Journal of Neuroinflammation 2012 9:105
  36. The interplay between IFN-γ, IL-17 and neutrophils during CNS inflammatory disease is complex due to cross-regulatory factors affecting both positive and negative feedback loops. These interactions have hinder...

    Authors: Carine Savarin, Stephen A Stohlman, David R Hinton, Richard M Ransohoff, Daniel J Cua and Cornelia C Bergmann
    Citation: Journal of Neuroinflammation 2012 9:104
  37. Blockade of angiotensin II type 1 (AT1) receptors ameliorates brain inflammation, and reduces excessive brain interleukin-1 beta (IL-1β) production and release from cortical microglia. The aim of this study was t...

    Authors: Tao Pang, Juan Wang, Julius Benicky, Enrique Sánchez-Lemus and Juan M Saavedra
    Citation: Journal of Neuroinflammation 2012 9:102
  38. Systemic inflammation might cause neuronal damage and sustain neurodegenerative diseases and behavior impairment, with the participation of pro-inflammatory cytokines, like tumor necrosis factor (TNF)-α and in...

    Authors: Paola Bossù, Debora Cutuli, Ilaria Palladino, Paola Caporali, Francesco Angelucci, Daniela Laricchiuta, Francesca Gelfo, Paola De Bartolo, Carlo Caltagirone and Laura Petrosini
    Citation: Journal of Neuroinflammation 2012 9:101
  39. Traumatic spinal cord injury (SCI) causes acute neuronal death followed by delayed secondary neuronal damage. However, little is known about how microenvironment regulating cells such as microglia, astrocytes,...

    Authors: Kyoung-Jin Min, Hey-Kyeong Jeong, Beomsue Kim, Dong Hoon Hwang, Hae Young Shin, An Tran Nguyen, Jong-hyeon Kim, Ilo Jou, Byung G Kim and Eun-hye Joe
    Citation: Journal of Neuroinflammation 2012 9:100
  40. Chronic neuroinflammation is an important component of Alzheimer’s disease and could contribute to neuronal dysfunction, injury and loss that lead to disease progression. Multiple clinical studies implicate tu...

    Authors: S Prasad Gabbita, Minu K Srivastava, Pirooz Eslami, Ming F Johnson, Naomi K Kobritz, David Tweedie, Nigel H Greig, Frank P Zemlan, Sherven P Sharma and Marni E Harris-White
    Citation: Journal of Neuroinflammation 2012 9:99
  41. Although evidence suggests that the prevalence of Parkinson’s disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nico...

    Authors: Yuan Liu, Jun Hu, Jie Wu, Chenlei Zhu, Yujian Hui, Yaping Han, Zuhu Huang, Kevin Ellsworth and Weimin Fan
    Citation: Journal of Neuroinflammation 2012 9:98
  42. Chronic alcohol use changes the brain’s inflammatory state. However, there is little work examining the progression of the cytokine response during alcohol withdrawal, a period of profound autonomic and emotio...

    Authors: Kate Freeman, Anthony Brureau, Rajanikanth Vadigepalli, Mary M Staehle, Melanie M Brureau, Gregory E Gonye, Jan B Hoek, D Craig Hooper and James S Schwaber
    Citation: Journal of Neuroinflammation 2012 9:97
  43. Cathepsin C (Cat C) functions as a central coordinator for activation of many serine proteases in inflammatory cells. It has been recognized that Cat C is responsible for neutrophil recruitment and production ...

    Authors: Kai Fan, Xuefei Wu, Bin Fan, Ning Li, Yongzhong Lin, Yiwen Yao and Jianmei Ma
    Citation: Journal of Neuroinflammation 2012 9:96

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    Journal Impact Factor: 9.3
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