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  1. The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immun...

    Authors: Kristina Berve, Brian L. West, Rudolf Martini and Janos Groh

    Citation: Journal of Neuroinflammation 2020 17:323

    Content type: Research

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  2. In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression, abnormal excessive opening of Cx43 hemich...

    Authors: Hailong Yu, Xiang Cao, Wei Li, Pinyi Liu, Yuanyuan Zhao, Lilong Song, Jian Chen, Beilei Chen, Wenkui Yu and Yun Xu

    Citation: Journal of Neuroinflammation 2020 17:322

    Content type: Research

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  3. Microglia have been implicated in the pathogenesis of radiation-induced brain injury (RIBI), which severely influences the quality of life during long-term survival. Recently, irradiated microglia were specula...

    Authors: Anan Xu, Rong Li, Anbang Ren, Haifeng Jian, Zhong Huang, Qingxing Zeng, Baiyao Wang, Jieling Zheng, Xiaoyu Chen, Naiying Zheng, Ronghui Zheng, Yunhong Tian, Mengzhong Liu, Zixu Mao, Aimin Ji and Yawei Yuan

    Citation: Journal of Neuroinflammation 2020 17:321

    Content type: Research

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  4. Aberrant hippocampal neurogenesis is an important pathological feature of sepsis-associated encephalopathy. In the current study, we examined the potential role of the long noncoding RNA (lncRNA) sex-determini...

    Authors: Jialin Yin, Yanan Shen, Yanna Si, Yuan Zhang, Jiayue Du, Xiajuan Hu, Mengmeng Cai, Hongguang Bao and Yan Xing

    Citation: Journal of Neuroinflammation 2020 17:320

    Content type: Research

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  5. Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide...

    Authors: Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan and Sujatha Kannan

    Citation: Journal of Neuroinflammation 2020 17:319

    Content type: Research

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  6. We previously found that high-dose methylprednisolone increased the incidence of critical illness-related corticosteroid insufficiency (CIRCI) and mortality in rats with traumatic brain injury (TBI), whereas l...

    Authors: Bin Zhang, Miao Bai, Xiaojian Xu, Mengshi Yang, Fei Niu, Fei Gao and Baiyun Liu

    Citation: Journal of Neuroinflammation 2020 17:318

    Content type: Research

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  7. The peri-menopause or menopausal transition—the time period that surrounds the final years of a woman’s reproductive life—is associated with profound reproductive and hormonal changes in a woman’s body and exp...

    Authors: Micheline McCarthy and Ami P. Raval

    Citation: Journal of Neuroinflammation 2020 17:317

    Content type: Review

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  8. Neuroinflammation is a critical feature of sensitisation of spinal nociceptive processing in chronic pain states. We hypothesised that the resolvin pathways, a unique endogenous control system, may ameliorate ...

    Authors: Pongsatorn Meesawatsom, Gareth Hathway, Andrew Bennett, Dumitru Constantin-Teodosiu and Victoria Chapman

    Citation: Journal of Neuroinflammation 2020 17:316

    Content type: Research

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  9. Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. JEV infection of mice and humans can lead to an uncontrolled inflammatory response in the central nervous system (CNS), res...

    Authors: Valerie Redant, Herman W. Favoreel, Kai Dallmeier, Willem Van Campe and Nick De Regge

    Citation: Journal of Neuroinflammation 2020 17:315

    Content type: Research

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  10. Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that s...

    Authors: Timothy M. Doyle, Mark R. Hutchinson, Kathryn Braden, Kali Janes, Vicky Staikopoulos, Zhoumou Chen, William L. Neumann, Sarah Spiegel and Daniela Salvemini

    Citation: Journal of Neuroinflammation 2020 17:314

    Content type: Short report

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  11. Targeting RNA polymerase-1 (POL1) machinery is a new strategy for suppression of multiple sclerosis (MS) relapse activity. Oral administration of POL1 inhibitor RAM-589.555, which is characterized by high perm...

    Authors: Rina Zilkha-Falb, Tatyana Rachutin-Zalogin, Lakota Cleaver, Michael Gurevich and Anat Achiron

    Citation: Journal of Neuroinflammation 2020 17:313

    Content type: Research

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  12. The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mech...

    Authors: Kohei Kanno, Kohei Shimizu, Masamichi Shinoda, Makoto Hayashi, Osamu Takeichi and Koichi Iwata

    Citation: Journal of Neuroinflammation 2020 17:312

    Content type: Research

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  13. Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggeri...

    Authors: Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan and Wen Wu

    Citation: Journal of Neuroinflammation 2020 17:311

    Content type: Research

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  14. The major dose-limiting toxicity of paclitaxel, one of the most commonly used drugs to treat solid tumor, is painful neuropathy. However, the molecular mechanisms underlying paclitaxel-induced painful neuropat...

    Authors: Meng Liu, Su-Bo Zhang, Yu-Xuan Luo, Yan-Ling Yang, Xiang-Zhong Zhang, Bo Li, Yan Meng, Yuan-Jie Chen, Rui-Xian Guo, Yuan-Chang Xiong, Wen-Jun Xin and Dai Li

    Citation: Journal of Neuroinflammation 2020 17:310

    Content type: Research

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  15. Endoplasmic reticulum (ER) stress is involved in the progression of Alzheimer’s disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated from Verbascum sinuatum (the wavyleaf mu...

    Authors: Chunyue Wang, Xueying Cai, Ruochen Wang, Siyu Zhai, Yongfeng Zhang, Wenji Hu, Yizhi Zhang and Di Wang

    Citation: Journal of Neuroinflammation 2020 17:309

    Content type: Research

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  16. The aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized 18F-THK-5351 positron-emission tomography (PET...

    Authors: Kuo-Lun Huang, Ing-Tsung Hsiao, Meng-Yang Ho, Jung-Lung Hsu, Yeu-Jhy Chang, Ting-Yu Chang, Chi-Hung Liu, Chien-Hung Chang, Yi-Ming Wu, Kuan-Yi Wu, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Tsong-Hai Lee and Kun-Ju Lin

    Citation: Journal of Neuroinflammation 2020 17:308

    Content type: Research

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  17. Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was p...

    Authors: Young-Hee Jin, Bongsu Kang, Hyun S. Kang, Chang-Sung Koh and Byung S. Kim

    Citation: Journal of Neuroinflammation 2020 17:307

    Content type: Research

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  18. Neuroinflammation is a principal element in Alzheimer’s disease (AD) pathogenesis, so anti-inflammation may be a promising therapeutic strategy. Forsythoside B (FTS•B), a phenylethanoid glycoside isolated from Fo...

    Authors: Fan’ge Kong, Xue Jiang, Ruochen Wang, Siyu Zhai, Yizhi Zhang and Di Wang

    Citation: Journal of Neuroinflammation 2020 17:305

    Content type: Research

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  19. Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune ence...

    Authors: Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Kevin Aguilar, Anna Escrig, Mercedes Giralt, Richard D. Palmiter and Juan Hidalgo

    Citation: Journal of Neuroinflammation 2020 17:304

    Content type: Research

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  20. Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against...

    Authors: Rahat Ullah, Myeung Hoon Jo, Muhammad Riaz, Sayed Ibrar Alam, Kamran Saeed, Waqar Ali, Inayat Ur Rehman, Muhammad Ikram and Myeong Ok Kim

    Citation: Journal of Neuroinflammation 2020 17:303

    Content type: Research

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  21. Glial activation and neuroinflammation play a crucial role in the pathogenesis and development of Alzheimer’s disease (AD). The receptor for advanced glycation end products (RAGE)-mediated signaling pathway is...

    Authors: Bo Ding, Chengheng Lin, Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma and Weina Yang

    Citation: Journal of Neuroinflammation 2020 17:302

    Content type: Research

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  22. Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads t...

    Authors: Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero Jr and Manoocher Soleimani

    Citation: Journal of Neuroinflammation 2020 17:301

    Content type: Research

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  23. Non-invasive imaging of the activation status of microglia and the ability to identify a pro- or anti-inflammatory environment can provide valuable insights not only into pathogenesis of neuro-inflammatory and...

    Authors: Wissam Beaino, Bieneke Janssen, Esther Kooijman, Ricardo Vos, Robert C. Schuit, James O’Brien-Brown, Michael Kassiou, Bert van het Hof, Danielle J. Vugts, Helga E. de Vries and Albert D. Windhorst

    Citation: Journal of Neuroinflammation 2020 17:300

    Content type: Research

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  24. Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases, such as frontotemporal lobar degeneration with ...

    Authors: Shinrye Lee, Seyeon Kim, Ha-Young Kang, Hye Ryeong Lim, Younghwi Kwon, Myungjin Jo, Yu-Mi Jeon, Sang Ryong Kim, Kiyoung Kim, Chang Man Ha, Seongsoo Lee and Hyung-Jun Kim

    Citation: Journal of Neuroinflammation 2020 17:299

    Content type: Research

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  25. Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive degeneration and loss of neurons in specific regions of the central nervous system. Chronic activation of the immune c...

    Authors: Chiara Burgaletto, Antonio Munafò, Giulia Di Benedetto, Cettina De Francisci, Filippo Caraci, Rosaria Di Mauro, Claudio Bucolo, Renato Bernardini and Giuseppina Cantarella

    Citation: Journal of Neuroinflammation 2020 17:298

    Content type: Review

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  26. MicroRNAs (miRNAs) belong to a class of evolutionary conserved, non-coding small RNAs with regulatory functions on gene expression. They negatively affect the expression of target genes by promoting either RNA...

    Authors: Qin Ma, Atsuko Matsunaga, Brenda Ho, Jorge R. Oksenberg and Alessandro Didonna

    Citation: Journal of Neuroinflammation 2020 17:297

    Content type: Research

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  27. Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of ...

    Authors: Patrick P. Lowe, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Abhishek Satishchandran, Istvan Furi, Yeonhee Cho, Benedek Gyongyosi, Donna Catalano, Eric Lefebvre, Laurent Fischer, Star Seyedkazemi, Dorothy P. Schafer and Gyongyi Szabo

    Citation: Journal of Neuroinflammation 2020 17:296

    Content type: Research

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  28. Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms co...

    Authors: Hong Fan, Hai-Bin Tang, Zhe Chen, Hu-Qing Wang, Lei Zhang, Yu Jiang, Tao Li, Cai-Feng Yang, Xiao-Ya Wang, Xia Li, Sheng-Xi Wu and Gui-Lian Zhang

    Citation: Journal of Neuroinflammation 2020 17:295

    Content type: Research

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  29. Myasthenia gravis (MG) is a rare autoimmune disease mainly mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction. The thymus is the effector organ, and its removal ...

    Authors: Mélanie A. Cron, Cloé A. Payet, Odessa-Maud Fayet, Solène Maillard, Frédérique Truffault, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Adrian Liston and Rozen Le Panse

    Citation: Journal of Neuroinflammation 2020 17:294

    Content type: Research

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  30. Pneumococcal meningitis (PM) remains a global public health concern and affects all age groups. If acquired during infancy or childhood, permanent neurofunctional deficits including cognitive impairment, cereb...

    Authors: Ngoc Dung Le, Lukas Muri, Denis Grandgirard, Jens Kuhle, David Leppert and Stephen L. Leib

    Citation: Journal of Neuroinflammation 2020 17:293

    Content type: Research

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  31. Sepsis-associated encephalopathy (SAE) is an early and frequent event of infection-induced systemic inflammatory response syndrome. Phosphoinositide 3-kinase γ (PI3Kγ) is linked to neuroinflammation and inflam...

    Authors: Guang-Ping Lang, Bernadin Ndongson-Dongmo, Trim Lajqi, Michael Brodhun, Yingying Han, Reinhard Wetzker, Martin G. Frasch and Reinhard Bauer

    Citation: Journal of Neuroinflammation 2020 17:292

    Content type: Research

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  32. Multiple sclerosis (MS) is an inflammatory demyelinating disease that affects 2.5 million people worldwide. Growing evidence suggests that perturbation of the gut microbiota, the dense collection of microorgan...

    Authors: John Michael S. Sanchez, Daniel J. Doty, Ana Beatriz DePaula-Silva, D. Garrett Brown, Rickesha Bell, Kendra A. Klag, Amanda Truong, Jane E. Libbey, June L. Round and Robert S. Fujinami

    Citation: Journal of Neuroinflammation 2020 17:291

    Content type: Research

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  33. Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cul...

    Authors: Julieta Saba, Federico López Couselo, Juan Turati, Lila Carniglia, Daniela Durand, Andrea de Laurentiis, Mercedes Lasaga and Carla Caruso

    Citation: Journal of Neuroinflammation 2020 17:290

    Content type: Research

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  34. Alzheimer’s disease (AD) is the most common type of dementia and a neurodegenerative disorder characterized by memory deficits especially forgetting recent information, recall ability impairment, and loss of t...

    Authors: Shaghayegh Sadeghmousavi, Mahsa Eskian, Farzaneh Rahmani and Nima Rezaei

    Citation: Journal of Neuroinflammation 2020 17:289

    Content type: Review

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  35. Growing evidence has shown that alterations in the gut microbiota composition were associated with a variety of neuropsychiatric conditions. However, whether such associations reflect causality remains unknown...

    Authors: Zhenhuang Zhuang, Ruotong Yang, Wenxiu Wang, Lu Qi and Tao Huang

    Citation: Journal of Neuroinflammation 2020 17:288

    Content type: Research

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  36. Current methods to repair ablation-type peripheral nerve injuries (PNIs) using peripheral nerve allografts (PNAs) often result in poor functional recovery due to immunological rejection as well as to slow and ...

    Authors: Tyler A. Smith, Cameron L. Ghergherehchi, Haley O. Tucker and George D. Bittner

    Citation: Journal of Neuroinflammation 2020 17:287

    Content type: Research

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  37. The coronavirus disease-19 (COVID-19) pandemic is an unprecedented worldwide health crisis. COVID-19 is caused by SARS-CoV-2, a highly infectious pathogen that is genetically similar to SARS-CoV. Similar to ot...

    Authors: Abbas Jarrahi, Meenakshi Ahluwalia, Hesam Khodadadi, Evila da Silva Lopes Salles, Ravindra Kolhe, David C. Hess, Fernando Vale, Manish Kumar, Babak Baban, Kumar Vaibhav and Krishnan M. Dhandapani

    Citation: Journal of Neuroinflammation 2020 17:286

    Content type: Review

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  38. Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding behavior and metabolic function that are often observed years prior to t...

    Authors: Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas, Abigail E. Salinero, Charly Abi-Ghanem, Yannick Poitelon, Sophie Belin and Kristen L. Zuloaga

    Citation: Journal of Neuroinflammation 2020 17:285

    Content type: Research

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  39. Tick-borne encephalitis virus (TBEV) is considered to be the medically most important arthropod-borne virus in Europe. The symptoms of an infection range from subclinical to mild flu-like disease to lethal enc...

    Authors: Richard Lindqvist, Ebba Rosendal, Elvira Weber, Naveed Asghar, Sarah Schreier, Annasara Lenman, Magnus Johansson, Gerhard Dobler, Malena Bestehorn, Andrea Kröger and Anna K. Överby

    Citation: Journal of Neuroinflammation 2020 17:284

    Content type: Research

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  40. Neuronal cytoplasmic inclusions containing TAR DNA-binding protein 43 (TDP-43) are a neuropathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotempor...

    Authors: Frank Zamudio, Anjanet R. Loon, Shayna Smeltzer, Khawla Benyamine, Nanda K. Navalpur Shanmugam, Nicholas J. F. Stewart, Daniel C. Lee, Kevin Nash and Maj-Linda B. Selenica

    Citation: Journal of Neuroinflammation 2020 17:283

    Content type: Research

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  41. Alterations in the immune system are a complication of spinal cord injury (SCI) and have been linked to an excessive sympathetic outflow to lymphoid organs. Still unknown is whether these peripheral immune cha...

    Authors: Susana Monteiro, Andreia G. Pinho, Mara Macieira, Cláudia Serre-Miranda, Jorge R. Cibrão, Rui Lima, Carina Soares-Cunha, Natália L. Vasconcelos, José Lentilhas-Graça, Sara Duarte-Silva, Alice Miranda, Margarida Correia-Neves, António J. Salgado and Nuno A. Silva

    Citation: Journal of Neuroinflammation 2020 17:282

    Content type: Research

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  42. Alzheimer’s disease (AD) is a progressive, late-onset dementia with no effective treatment available. Recent studies suggest that AD pathology is driven by age-related changes in metabolism. Alterations in met...

    Authors: Daniel C. Shippy, Connor Wilhelm, Patel A. Viharkumar, Thomas J. Raife and Tyler K. Ulland

    Citation: Journal of Neuroinflammation 2020 17:280

    Content type: Short report

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  43. Microglia, the primary resident myeloid cells of the brain, play critical roles in immune defense by maintaining tissue homeostasis and responding to injury or disease. However, microglial activation and dysfu...

    Authors: Lindsay A. Hohsfield, Allison R. Najafi, Yasamine Ghorbanian, Neelakshi Soni, Edna E. Hingco, Sung Jin Kim, Ayer Darling Jue, Vivek Swarup, Mathew A. Inlay and Kim N. Green

    Citation: Journal of Neuroinflammation 2020 17:279

    Content type: Research

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  44. Tick-borne encephalitis virus (TBEV) is an important human pathogen that can cause the serious illness tick-borne encephalitis (TBE). Patients with clinical symptoms can suffer from severe meningoencephalitis ...

    Authors: Angela D. A. Cornelius, Shirin Hosseini, Sarah Schreier, David Fritzsch, Loreen Weichert, Kristin Michaelsen-Preusse, Markus Fendt and Andrea Kröger

    Citation: Journal of Neuroinflammation 2020 17:278

    Content type: Research

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  45. Tay-Sachs disease (TSD), a type of GM2-gangliosidosis, is a progressive neurodegenerative lysosomal storage disorder caused by mutations in the α subunit of the lysosomal β-hexosaminidase enzyme. This disease is ...

    Authors: Seçil Akyıldız Demir, Zehra Kevser Timur, Nurselin Ateş, Luis Alarcón Martínez and Volkan Seyrantepe

    Citation: Journal of Neuroinflammation 2020 17:277

    Content type: Research

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  46. In human immunodeficiency virus-1 (HIV-1) infection, activation of astrocytes induces imbalance in physiological functions due to perturbed astrocytic functions that unleashes toxicity on neurons. This leads t...

    Authors: Priyanka, Renu Wadhwa, Rituparna Chaudhuri, Tapas Chandra Nag and Pankaj Seth

    Citation: Journal of Neuroinflammation 2020 17:276

    Content type: Research

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  47. B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The therapeutic success of monoclonal antib...

    Authors: Marc Y. Stevens, Haley C. Cropper, Katherine L. Lucot, Aisling M. Chaney, Kendra J. Lechtenberg, Isaac M. Jackson, Marion S. Buckwalter and Michelle L. James

    Citation: Journal of Neuroinflammation 2020 17:275

    Content type: Research

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  48. Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the ne...

    Authors: Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona and Amanda M. Brown

    Citation: Journal of Neuroinflammation 2020 17:273

    Content type: Research

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