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  1. Research

    Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

    Choroid plexus (CP) supports the entry of monocyte-derived macrophages (MDMs) to the central nervous system in animal models of traumatic brain injury, spinal cord injury, and Alzheimer’s disease. Whether the ...

    Ruimin Ge, Daniel Tornero, Masao Hirota, Emanuela Monni, Cecilia Laterza, Olle Lindvall and Zaal Kokaia

    Journal of Neuroinflammation 2017 14:153

    Published on: 28 July 2017

  2. Research

    Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception

    Tissue acidosis and inflammatory mediators play critical roles in pain. Pro-inflammatory agents trypsin and tryptase cleave and activate proteinase-activated receptor 2 (PAR2) expressed on sensory nerves, which i...

    Jing Wu, Ting-Ting Liu, Yi-Mei Zhou, Chun-Yu Qiu, Ping Ren, Ming Jiao and Wang-Ping Hu

    Journal of Neuroinflammation 2017 14:150

    Published on: 28 July 2017

  3. Research

    Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment

    We previously found that subjects with amnestic mild cognitive impairment exhibit a pro-inflammatory immune profile in the cerebrospinal fluid similar to multiple sclerosis, a central nervous system autoimmune...

    Ann M. Stowe, Sara J. Ireland, Sterling B. Ortega, Ding Chen, Ryan M. Huebinger, Takashi Tarumi, Thomas S. Harris, C. Munro Cullum, Roger Rosenberg, Nancy L. Monson and Rong Zhang

    Journal of Neuroinflammation 2017 14:149

    Published on: 27 July 2017

  4. Research

    Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients

    Multiple sclerosis (MS) is an autoimmune disorder characterized by chronic inflammation, demyelination, and neuronal damage. During autoimmunity, cytokines are important mediators of the inflammation. In this ...

    Patrice H. Lalive, Mario Kreutzfeldt, Odile Devergne, Imke Metz, Wolfgang Bruck, Doron Merkler and Caroline Pot

    Journal of Neuroinflammation 2017 14:144

    Published on: 24 July 2017

  5. Research

    TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders

    Inflammation during brain development participates in the pathogenesis of early brain injury and cognitive dysfunctions. Prenatal ethanol exposure affects the developing brain and causes neural impairment, cog...

    María Pascual, Jorge Montesinos, Sandra Montagud-Romero, Jerónimo Forteza, Marta Rodríguez-Arias, José Miñarro and Consuelo Guerri

    Journal of Neuroinflammation 2017 14:145

    Published on: 24 July 2017

  6. Research

    Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

    Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) prote...

    Xiangrong Chen, Shukai Wu, Chunnuan Chen, Baoyuan Xie, Zhongning Fang, Weipeng Hu, Junyan Chen, Huangde Fu and Hefan He

    Journal of Neuroinflammation 2017 14:143

    Published on: 24 July 2017

  7. Research

    Differential effects of FTY720 on the B cell compartment in a mouse model of multiple sclerosis

    MP4-induced experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis (MS), which enables targeted research on B cells, currently much discussed protagonists in MS pathogenesis. He...

    Kathrin Bail, Quirin Notz, Damiano M. Rovituso, Andrea Schampel, Marie Wunsch, Tobias Koeniger, Verena Schropp, Richa Bharti, Claus-Juergen Scholz, Konrad U. Foerstner, Christoph Kleinschnitz and Stefanie Kuerten

    Journal of Neuroinflammation 2017 14:148

    Published on: 24 July 2017

  8. Research

    Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

    The necessity of including both males and females in molecular neuroscience research is now well understood. However, there is relatively limited basic biological data on brain sex differences across the lifes...

    Colleen A. Mangold, Benjamin Wronowski, Mei Du, Dustin R. Masser, Niran Hadad, Georgina V. Bixler, Robert M. Brucklacher, Matthew M. Ford, William E. Sonntag and Willard M. Freeman

    Journal of Neuroinflammation 2017 14:141

    Published on: 21 July 2017

  9. Research

    Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

    Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammat...

    Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi and Keisuke Yoshikawa

    Journal of Neuroinflammation 2017 14:142

    Published on: 21 July 2017

  10. Research

    Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage

    Neuroinflammation mediated by NLRP1 (nucleotide-binding oligomerization domain (NOD)-like receptor protein 1) inflammasome plays an important role in many neurological diseases such as Parkinson’s disease (PD)...

    Biqiong Zhang, Yaodong Zhang, Wenning Wu, Tanzhen Xu, Yanyan Yin, Junyan Zhang, Dake Huang and Weizu Li

    Journal of Neuroinflammation 2017 14:139

    Published on: 21 July 2017

  11. Research

    Ischaemic stroke and the recanalization drug tissue plasminogen activator interfere with antibacterial phagocyte function

    Stroke induces immune alterations such as impaired oxidative burst and reduced release of neutrophil extracellular traps (NETs). We hypothesised that key enzymes of these defence mechanisms may be altered in i...

    Antje Vogelgesang, Claudia Lange, Lara Blümke, Georg Laage, Sarah Rümpel, Sönke Langner, Barbara M. Bröker, Alexander Dressel and Johanna Ruhnau

    Journal of Neuroinflammation 2017 14:140

    Published on: 21 July 2017

  12. Research

    MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis

    Controversy exists regarding which cell types are responsible for autoantigen presentation in the retina during experimental autoimmune uveitis (EAU) development. In this study, we aimed to identify and charac...

    Deborah A. Lipski, Rémi Dewispelaere, Vincent Foucart, Laure E. Caspers, Matthieu Defrance, Catherine Bruyns and François Willermain

    Journal of Neuroinflammation 2017 14:136

    Published on: 18 July 2017

  13. Research

    Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats

    Heparanase, a mammalian endo-β-D-glucoronidase that specifically degrades heparan sulfate, has been implicated in inflammation and ischemic stroke. However, the role of heparanase in neuroinflammatory response...

    Benjarat Changyaleket, Zhao Zhong Chong, Randal O. Dull, Danop Nanegrungsunk and Haoliang Xu

    Journal of Neuroinflammation 2017 14:137

    Published on: 18 July 2017

  14. Research

    The role of microglial P2X7: modulation of cell death and cytokine release

    ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflamma...

    Yingbo He, Natalie Taylor, Lawrence Fourgeaud and Anindya Bhattacharya

    Journal of Neuroinflammation 2017 14:135

    Published on: 17 July 2017

  15. Research

    Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

    During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in t...

    Stephanie M. Krasnow, J. Gabriel Knoll, Santhosh Chakkaramakkil Verghese, Peter R. Levasseur and Daniel L. Marks

    Journal of Neuroinflammation 2017 14:133

    Published on: 1 July 2017

  16. Research

    Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

    Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial act...

    Min Yin, Zhiying Chen, Yetong Ouyang, Huiyan Zhang, Zhigang Wan, Han Wang, Wei Wu and Xiaoping Yin

    Journal of Neuroinflammation 2017 14:132

    Published on: 29 June 2017

  17. Research

    Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

    The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets...

    Paul R. Lee, Tory P. Johnson, Sharmilee Gnanapavan, Gavin Giovannoni, Tongguang Wang, Joseph P. Steiner, Marie Medynets, Mark J. Vaal, Valerie Gartner and Avindra Nath

    Journal of Neuroinflammation 2017 14:131

    Published on: 27 June 2017

  18. Research

    The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury

    The endogenously produced gaseous molecule carbon monoxide is able to promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon monoxide releasing molecules (CORM) regarding infl...

    Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, Carlos C. Romao, Nils Schallner, Ulrich Goebel and Julia Biermann

    Journal of Neuroinflammation 2017 14:130

    Published on: 27 June 2017

  19. Research

    A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

    Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the mo...

    Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried and Allan I. Levey

    Journal of Neuroinflammation 2017 14:128

    Published on: 26 June 2017

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