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  1. Content type: Research

    Alzheimer’s disease is characterized by progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in internalization and degradation of Aβ. Our previous research...

    Authors: Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun and Hong Liao

    Citation: Journal of Neuroinflammation 2018 15:210

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  2. Content type: Research

    There is a need for clinically useful biomarkers of disease activity in clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS). The aim of this study was to assess the correlation between neurofi...

    Authors: Irene Håkansson, Anders Tisell, Petra Cassel, Kaj Blennow, Henrik Zetterberg, Peter Lundberg, Charlotte Dahle, Magnus Vrethem and Jan Ernerudh

    Citation: Journal of Neuroinflammation 2018 15:209

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  3. Content type: Research

    Myelin oligodendrocyte glycoprotein (MOG)-reactive T-helper (Th)1 cells induce conventional experimental autoimmune encephalomyelitis (cEAE), characterized by ascending paralysis and monocyte-predominant spina...

    Authors: Joshua S. Stoolman, Patrick C. Duncker, Amanda K. Huber, David A. Giles, Jesse M. Washnock-Schmid, Athena M. Soulika and Benjamin M. Segal

    Citation: Journal of Neuroinflammation 2018 15:208

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  4. Content type: Research

    Although rates of severe HIV-associated neurocognitive disorders have declined in the post-antiretroviral treatment (ART) era, subtle deficits persist, possibly exacerbated by treatment non-adherence. The actu...

    Authors: William Schreiber-Stainthorp, Sanhita Sinharay, Sharat Srinivasula, Swati Shah, Jing Wang, Lori Dodd, H. Clifford Lane, Michele Di Mascio and Dima A. Hammoud

    Citation: Journal of Neuroinflammation 2018 15:207

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  5. Content type: Research

    Parkinson’s disease (PD) affects an estimated 7 to 10 million people worldwide, and only symptomatic treatments are presently available to relieve the consequences of brain dopaminergic neurons loss. Neuronal ...

    Authors: Natasa Kustrimovic, Cristoforo Comi, Luca Magistrelli, Emanuela Rasini, Massimiliano Legnaro, Raffaella Bombelli, Iva Aleksic, Fabio Blandini, Brigida Minafra, Giulio Riboldazzi, Andrea Sturchio, Marco Mauri, Giorgio Bono, Franca Marino and Marco Cosentino

    Citation: Journal of Neuroinflammation 2018 15:205

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  6. Content type: Research

    The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection against cerebral ischemic injury by activating estrogen receptors. The novel estrogen receptor G protein-coupled receptor 30 (GPR30) i...

    Authors: Zengli Zhang, Pei Qin, Youliang Deng, Zhi Ma, Hang Guo, Haiyun Guo, Yushu Hou, Shiquan Wang, Wangyuan Zou, Yanyuan Sun, Yulong Ma and Wugang Hou

    Citation: Journal of Neuroinflammation 2018 15:206

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  7. Content type: Research

    Neuroinflammation is a common therapeutic target for traumatic brain injury (TBI) due to its contribution to delayed secondary cell death and has the potential to occur for years after the initial insult. Exos...

    Authors: Niketa A. Patel, Lauren Daly Moss, Jea-Young Lee, Naoki Tajiri, Sandra Acosta, Charles Hudson, Sajan Parag, Denise R. Cooper, Cesario V. Borlongan and Paula C. Bickford

    Citation: Journal of Neuroinflammation 2018 15:204

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  8. Content type: Research

    Epilepsy is a prevalent neurological disorder worldwide. It is characterized by an enduring predisposition to generate seizures and its development is accompanied by alterations in many cellular processes. Org...

    Authors: Daniela M. Magalhães, Noémia Pereira, Diogo M. Rombo, Cláudia Beltrão-Cavacas, Ana M. Sebastião and Cláudia A. Valente

    Citation: Journal of Neuroinflammation 2018 15:203

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  9. Content type: Research

    Phospholipids in the central nervous system are enriched in n-3 and n-6 polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) and arachidonic acid (ARA). These PUFA can undergo enzymatic re...

    Authors: Bo Yang, Runting Li, C. Michael Greenlief, Kevin L. Fritsche, Zezong Gu, Jiankun Cui, James C. Lee, David Q. Beversdorf and Grace Y. Sun

    Citation: Journal of Neuroinflammation 2018 15:202

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  10. Content type: Research

    Following injury to the central nervous system, increased microglia, secretion of pro- and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark of degeneration, are observed at...

    Authors: Nicole M. Smith, Marcus K. Giacci, Alexander Gough, Charlotte Bailey, Terence McGonigle, Anna M. B. Black, Thomas O. Clarke, Carole A. Bartlett, K. Swaminathan Iyer, Sarah A. Dunlop and Melinda Fitzgerald

    Citation: Journal of Neuroinflammation 2018 15:201

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  11. Content type: Review

    Programmed cell death has a vital role in embryonic development and tissue homeostasis. Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis and necrosis. Necroptosis requ...

    Authors: Yogesh K. Dhuriya and Divakar Sharma

    Citation: Journal of Neuroinflammation 2018 15:199

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  12. Content type: Research

    It is well established that lung pathology and inflammation are more severe during respiratory infections complicated by the presence of both bacteria and viruses. Whilst co-infection can result in invasive pn...

    Authors: Hao Wang, Melissa Blackall, Luba Sominsky, Sarah J. Spencer, Ross Vlahos, Melissa Churchill and Steven Bozinovski

    Citation: Journal of Neuroinflammation 2018 15:200

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  13. Content type: Research

    Stroke is the second leading cause of death worldwide and the most common cause of adult-acquired disability in many nations. Thus, attenuating the damage after ischemic injury and improving patient prognosis ...

    Authors: Di Ma, Liangshu Feng, Yingying Cheng, Meiying Xin, Jiulin You, Xiang Yin, Yulei Hao, Li Cui and Jiachun Feng

    Citation: Journal of Neuroinflammation 2018 15:198

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  14. Content type: Research

    Neuroinflammation and microglial activation have been implicated in both alcohol use disorders (AUD) and fetal alcohol spectrum disorders (FASD). Chemokine monocyte chemoattractant protein 1 (MCP-1) and its re...

    Authors: Kai Zhang, Haiping Wang, Mei Xu, Jacqueline A. Frank and Jia Luo

    Citation: Journal of Neuroinflammation 2018 15:197

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  15. Content type: Short report

    Lipopolysaccharide (LPS) is one of the main constituents of the cell wall of gram-negative bacteria. As an endotoxin, LPS induces neuroinflammation, which is associated with the blood-brain barrier impairment....

    Authors: Elizaveta B. Boitsova, Andrey V. Morgun, Elena D. Osipova, Elena A. Pozhilenkova, Galina P. Martinova, Olga V. Frolova, Raissa Ya Olovannikova, Abolghasem Tohidpour, Yana V. Gorina, Yulia A. Panina and Alla B. Salmina

    Citation: Journal of Neuroinflammation 2018 15:196

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  16. Content type: Review

    Stroke is the fifth leading cause of death and the leading cause of long-term disability in the USA, costing $40.2 billion in direct and indirect costs. Globally, stroke is the second leading cause of death an...

    Authors: Hilary A. Seifert and Halina Offner

    Citation: Journal of Neuroinflammation 2018 15:195

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  17. Content type: Research

    Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia...

    Authors: Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu and Gang Hu

    Citation: Journal of Neuroinflammation 2018 15:193

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  18. Content type: Research

    Neuroinflammation accompanies neural trauma and most neurological diseases. Axotomy in the peripheral nervous system (PNS) leads to dramatic changes in the injured neuron: the cell body expresses a distinct se...

    Authors: Jane A. Lindborg, Jon P. Niemi, Madeline A. Howarth, Kevin W. Liu, Christian Z. Moore, Deepti Mahajan and Richard E. Zigmond

    Citation: Journal of Neuroinflammation 2018 15:192

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  19. Content type: Research

    Chronic noise exposure is associated with neuroinflammation and gut microbiota dysregulation and increases the risk of Alzheimer’s disease (AD). Environmental hazards are also thought to be associated with gen...

    Authors: Bo Cui, Donghong Su, Wenlong Li, Xiaojun She, Ming Zhang, Rui Wang and Qingfeng Zhai

    Citation: Journal of Neuroinflammation 2018 15:190

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  20. Content type: Case study

    The perinatal period carries the highest risk for stroke in childhood; however, the pathophysiology is poorly understood and preventive, prognostic, and therapeutic strategies are not available. A new pathophy...

    Authors: Anna Bajnok, László Berta, Csaba Orbán, Tivadar Tulassay and Gergely Toldi

    Citation: Journal of Neuroinflammation 2018 15:191

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  21. Content type: Research

    Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential f...

    Authors: Afrânio Ferreira Evangelista, Marcos André Vannier-Santos, Gessica Sabrina de Assis Silva, Daniela Nascimento Silva, Paulo José Lima Juiz, Carolina Kymie Vasques Nonaka, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares and Cristiane Flora Villarreal

    Citation: Journal of Neuroinflammation 2018 15:189

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  22. Content type: Research

    Management of neuropathic pain is a real clinical challenge. Despite intense investigation, the mechanisms of neuropathic pain remain substantially unidentified. Matrix metalloproteinase (MMP)-9 and MMP-2 have...

    Authors: Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wen-Tao Liu, Liang Hu and Yinbing Pan

    Citation: Journal of Neuroinflammation 2018 15:187

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  23. Content type: Research

    At low levels, carbon monoxide (CO) has been shown to have beneficial effects on multiple organs and tissues through its potential anti-inflammatory, anti-apoptotic, and anti-proliferative properties. However,...

    Authors: Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang and Jian Wang

    Citation: Journal of Neuroinflammation 2018 15:188

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  24. Content type: Research

    Neonatal hypoxic-ischemic brain damage, characterized by tissue loss and neurologic dysfunction, is a leading cause of mortality and a devastating disease of the central nervous system. We have previously show...

    Authors: Wen-di Luo, Jia-wei Min, Wen-Xian Huang, Xin Wang, Yuan-yuan Peng, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He and Bi-Wen Peng

    Citation: Journal of Neuroinflammation 2018 15:186

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