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  1. Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. Heterozygous loss-of-function mutations in TREM2,...

    Authors: Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini and Derya R. Shimshek
    Citation: Journal of Neuroinflammation 2023 20:29
  2. Retinal melanosome/melanolipofuscin-containing cells (MCCs), clinically visible as hyperreflective foci (HRF) and a highly predictive imaging biomarker for the progression of age-related macular degeneration (...

    Authors: Sebastien Augustin, Marion Lam, Sophie Lavalette, Anna Verschueren, Frédéric Blond, Valérie Forster, Lauriane Przegralek, Zhiguo He, Daniel Lewandowski, Alexis-Pierre Bemelmans, Serge Picaud, José-Alain Sahel, Thibaud Mathis, Michel Paques, Gilles Thuret, Xavier Guillonneau…
    Citation: Journal of Neuroinflammation 2023 20:28
  3. Inflammasome activation has a pathogenic role in Parkinson’s disease (PD). Up-regulated expressions of inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) and assembly of ASC s...

    Authors: Ran Zheng, Yiqun Yan, Shaobing Dai, Yang Ruan, Ying Chen, Chenjun Hu, Zhihao Lin, Naijia Xue, Zhe Song, Yi Liu, Baorong Zhang and Jiali Pu
    Citation: Journal of Neuroinflammation 2023 20:26
  4. Clustering of microglia around the vasculature has been reported in the retina and the brain after systemic administration of lipopolysaccharides (LPS) in mice. LPS acts via activation of Toll-like receptor 4 ...

    Authors: Ioanna Tsioti, Beatrice L. Steiner, Pascal Escher, Martin S. Zinkernagel, Peter M. Benz and Despina Kokona
    Citation: Journal of Neuroinflammation 2023 20:25
  5. Previous reports have indicated that disrupting the Wnt/β-catenin pathway in dendritic cells (DCs) may affect the progression of autoimmune inflammation; however, the factors and timing that regulate Wnt/β-cat...

    Authors: Zhihui Zhang, Yongtao Li, Nu Chen, Huan Li, Shuang Chen, Xuexue Cui, Hui Shao, Lai Wei, Jianxing Ma, Song Zhang, Xiaorong Li and Xiaomin Zhang
    Citation: Journal of Neuroinflammation 2023 20:24
  6. The microbiota–gut–brain axis plays an important role in the development of depression. The aim of this study was to investigate the effects of 5-HT on cognitive function, learning and memory induced by chroni...

    Authors: Junxing Ma, Ran Wang, Yaoxing Chen, Zixu Wang and Yulan Dong
    Citation: Journal of Neuroinflammation 2023 20:23
  7. Postoperative pain is a serious clinical problem with a poorly understood mechanism, and lacks effective treatment. Hydrogen (H2) can reduce neuroinflammation; therefore, we hypothesize that H2 may alleviate post...

    Authors: Juan Li, Shirong Ruan, Jinhui Jia, Qian Li, Rumeng Jia, Li Wan, Xing Yang, Peng Teng, Qilin Peng, Ya-dan Shi, Pan Yu, Yinbing Pan, Man-lin Duan, Wen-Tao Liu, Li Zhang and Liang Hu
    Citation: Journal of Neuroinflammation 2023 20:22
  8. The impairment in the autophagy-lysosomal pathway (ALP) and the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration and neuroinfl...

    Authors: Wenjia Lin, Zhao Li, Guangfeng Liang, Runjin Zhou, Xiaoyan Zheng, Rongrong Tao, Qingwei Huo, Chengfu Su, Min Li, Nenggui Xu, Chunzhi Tang and Ju-Xian Song
    Citation: Journal of Neuroinflammation 2023 20:21
  9. Chronic microglia activation post-stroke is associated with worse neurological and cognitive outcomes. However, measurement of microglia activation in vivo is currently limited. Plasma derived extracellular ve...

    Authors: A. D. Roseborough, S. J. Myers, R. Khazaee, Y. Zhu, L. Zhao, E. Iorio, F. M. Elahi, S. H. Pasternak and S. N. Whitehead
    Citation: Journal of Neuroinflammation 2023 20:20
  10. Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by progressive cognitive dysfunctions and behavioral impairments. Patchouli alcohol (PA), isolated from Pogostemonis Herba, exhibits m...

    Authors: Qing-Qing Xu, Zi-Ren Su, Wen Yang, Mei Zhong, Yan-Fang Xian and Zhi-Xiu Lin
    Citation: Journal of Neuroinflammation 2023 20:19
  11. The presence of meningeal ectopic lymphoid structures (ELS) in a subgroup of patients diagnosed with secondary progressive multiple sclerosis (SPMS) corresponds to a pronounced cortical inflammation and an agg...

    Authors: Verena Schropp, Rittika Chunder, Barbara Dietel, Sabine Tacke and Stefanie Kuerten
    Citation: Journal of Neuroinflammation 2023 20:18
  12. 2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid. Inhibition of 2-AG metabolism by inactivation of monoacylglycerol lipase (MAGL), the primary enzyme that degrades 2-AG in the brain, p...

    Authors: Dexiao Zhu, Jian Zhang, Jack Hashem, Fei Gao and Chu Chen
    Citation: Journal of Neuroinflammation 2023 20:17
  13. Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). Anxiety and depression are the most common psychiatric comorbidities of MS, which seriously affect patients’ ...

    Authors: Zhenghao Li, Kefu Chen, Qi Shao, Hongtao Lu, Xin Zhang, Yingyan Pu, Xuejun Sun, Hua He and Li Cao
    Citation: Journal of Neuroinflammation 2023 20:16
  14. The mechanisms by which neonatal inflammation leads to cognitive deficits in adulthood remain poorly understood. Inhibitory GABAergic synaptic transmission plays a vital role in controlling learning, memory an...

    Authors: Jing Rong, Yang Yang, Min Liang, Haiquan Zhong, Yingchun Li, Yichao Zhu, Sha Sha, Lei Chen and Rong Zhou
    Citation: Journal of Neuroinflammation 2023 20:15
  15. We have investigated the efficacy of a new strategy to limit pathological retinal neovascularization (RNV) during ischemic retinopathy by targeting the cholesterol metabolizing enzyme acyl-coenzyme A: choleste...

    Authors: Syed A. H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Leila Labazi, Robert W. Caldwell, Ruth B. Caldwell and Modesto A. Rojas
    Citation: Journal of Neuroinflammation 2023 20:14
  16. This study identified early immune gene responses in peripheral blood associated with 90-day ischemic stroke (IS) outcomes.

    Authors: Hajar Amini, Bodie Knepp, Fernando Rodriguez, Glen C. Jickling, Heather Hull, Paulina Carmona-Mora, Cheryl Bushnell, Bradley P. Ander, Frank R. Sharp and Boryana Stamova
    Citation: Journal of Neuroinflammation 2023 20:13
  17. Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition of new and persistent functional limitations in sepsis surviv...

    Authors: Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha and Rajesh K. Aneja
    Citation: Journal of Neuroinflammation 2023 20:12
  18. Ischemic stroke in white matter of the brain induces not only demyelination, but also neuroinflammation. Peripheral T lymphocytes, especially regulatory T cells (Tregs), are known to infiltrate into ischemic b...

    Authors: Bin Xu, Hiroya Shimauchi-Ohtaki, Yuhei Yoshimoto, Tetsushi Sadakata and Yasuki Ishizaki
    Citation: Journal of Neuroinflammation 2023 20:11
  19. Lyme neuroborreliosis, caused by the bacterium Borrelia burgdorferi affects both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations, especially at later stages, can mimic/cause many oth...

    Authors: Geetha Parthasarathy, Melissa B. Pattison and Cecily C. Midkiff
    Citation: Journal of Neuroinflammation 2023 20:10
  20. Acetylcholine receptor (AChR) myasthenia gravis (MG) is a chronic autoimmune disease characterized by muscle weakness. The AChR+ autoantibodies are produced by B-cells located in thymic ectopic germinal centers (...

    Authors: José A. Villegas, Jérôme Van Wassenhove, Judith Merrheim, Karen Matta, Samy Hamadache, Clémence Flaugère, Pauline Pothin, Frédérique Truffault, Sébastien Hascoët, Nicola Santelmo, Marco Alifano, Sonia Berrih-Aknin, Rozen le Panse and Nadine Dragin
    Citation: Journal of Neuroinflammation 2023 20:9
  21. The innate lymphoid cell (ILC) family consists of NK cells, ILC type 1, 2, 3 and lymphoid tissue inducer cells. They have been shown to play important roles in homeostasis and immune responses and are generall...

    Authors: Shuaiwei Wang, Lauriane de Fabritus, Praveen Ashok Kumar, Yves Werner, Minglu Ma, Dan Li, Carole Siret, Milesa Simic, Bin Li, Yann M. Kerdiles, Lei Hou, Ralf Stumm and Serge A. van de Pavert
    Citation: Journal of Neuroinflammation 2023 20:8
  22. Promotion of myelin repair in the context of demyelinating diseases such as multiple sclerosis (MS) still represents a clinical unmet need, given that this disease is not only characterized by autoimmune activ...

    Authors: Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini and Patrick Küry
    Citation: Journal of Neuroinflammation 2023 20:7
  23. Spinal cord injury (SCI) is a devastating injury that may result in permanent motor impairment. The active ingredients of medications are unable to reach the affected area due to the blood‒brain barrier. Elami...

    Authors: Haojie Zhang, Yituo Chen, Feida Li, Chenyu Wu, Wanta Cai, Hantao Ye, Haohan Su, Mingjun He, Liangliang Yang, Xiangyang Wang, Kailiang Zhou and Wenfei Ni
    Citation: Journal of Neuroinflammation 2023 20:6
  24. In response to brain injury or inflammation, astrocytes undergo hypertrophy, proliferate, and migrate to the damaged zone. These changes, collectively known as "astrogliosis", initially protect the brain; howe...

    Authors: Ramón Pérez-Núñez, Alejandro Chamorro, María Fernanda González, Pamela Contreras, Rocío Artigas, Alejandro H. Corvalán, Brigitte van Zundert, Christopher Reyes, Pablo R. Moya, Ana María Avalos, Pascal Schneider, Andrew F. G. Quest and Lisette Leyton
    Citation: Journal of Neuroinflammation 2023 20:5
  25. Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growt...

    Authors: Maximilian Bellut, Michael Bieber, Peter Kraft, Alexander N. R. Weber, Guido Stoll and Michael K. Schuhmann
    Citation: Journal of Neuroinflammation 2023 20:4
  26. Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ing...

    Authors: Evangelos Konstantinidis, Benjamin Portal, Tobias Mothes, Chiara Beretta, Maria Lindskog and Anna Erlandsson
    Citation: Journal of Neuroinflammation 2023 20:3
  27. Authors: Ke Zhong, Yu Huang, Prince last Mudenda Zilundu, Yaqiong Wang, Yingying Zhou, Guangyin Yu, Rao Fu, Sookja Kim Chung, Yamei Tang, Xiao Cheng and Lihua Zhou
    Citation: Journal of Neuroinflammation 2023 20:2

    The original article was published in Journal of Neuroinflammation 2022 19:271

  28. Chronic hyperammonemia, a main contributor to hepatic encephalopathy (HE), leads to neuroinflammation which alters neurotransmission leading to cognitive impairment. There are no specific treatments for the ne...

    Authors: Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Mar Martínez-García, Carlos Sánchez-Huertas, Alberto Hernández, Victoria Moreno-Manzano and Vicente Felipo
    Citation: Journal of Neuroinflammation 2023 20:1
  29. Regulatory CD4+CD25+FoxP3+ T cells (Treg) are a subgroup of T lymphocytes involved in maintaining immune balance. Disturbance of Treg number and impaired suppressive function of Treg correlate with Parkinson’s di...

    Authors: Mohammad Badr, Rhonda L. McFleder, Jingjing Wu, Susanne Knorr, James B. Koprich, Thomas Hünig, Jonathan M. Brotchie, Jens Volkmann, Manfred B. Lutz and Chi Wang Ip
    Citation: Journal of Neuroinflammation 2022 19:319
  30. Neuroinflammation in the nucleus accumbens (NAc) is well known to influence the progression of depression. However, the molecular mechanisms triggering NAc neuroinflammation in depression have not been fully e...

    Authors: Jing Wang, Simin Lai, Ting Zhou, Zhihao Xia, Weina Li, Wenqi Sha, Jingjie Liu and Yanjiong Chen
    Citation: Journal of Neuroinflammation 2022 19:318
  31. Authors: Weifen Li, Tahir Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, Fawad Ali Shah, Qingguo Ren, Shafiq Ur Rahman, Ningning Li, Zhi-Jian Yu and Shupeng Li
    Citation: Journal of Neuroinflammation 2022 19:317

    The original article was published in Journal of Neuroinflammation 2021 18:38

  32. Dysfunction of glial cell communication is involved in Alzheimer’s disease (AD) pathogenesis, and the recent study reported that astrocytic secreted interleukin-3 (IL-3) participated in astrocyte–microglia cro...

    Authors: Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang and Jin-Tai Yu
    Citation: Journal of Neuroinflammation 2022 19:316
  33. Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many inflammasome inhibitors targeting NOD-like recept...

    Authors: Chen Chen, YuWei Zhou, XinPeng Ning, ShengLong Li, DongDong Xue, CaiLv Wei, Zhu Zhu, LongXiang Sheng, BingZheng Lu, Yuan Li, XiaoYuan Ye, YunZhao Fu, Chuan Bai, Wei Cai, YuXuan Ding, SuiZhen Lin…
    Citation: Journal of Neuroinflammation 2022 19:315
  34. Brain lactate concentrations are enhanced in response to cerebral ischemia and promote the formation of reactive astrocytes, which are major components of the neuroinflammatory response and functional recovery...

    Authors: Jinying Xu, Tong Ji, Guichen Li, Haiying Zhang, Yangyang Zheng, Meiying Li, Jie Ma, Yulin Li and Guangfan Chi
    Citation: Journal of Neuroinflammation 2022 19:314
  35. Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, the effects of gut microbiota and short-chain fatty acids (SCFAs)...

    Authors: Shao-Hua Su, Yi-Fang Wu, Qi Lin, Lin Zhang, Da-Peng Wang and Jian Hai
    Citation: Journal of Neuroinflammation 2022 19:313
  36. Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients with subarachnoid hemorrhage (SAH). We investigated the role of C–C motif chemokine receptor 2 (CCR2) in SAH.

    Authors: Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang and Mingchang Li
    Citation: Journal of Neuroinflammation 2022 19:312
  37. Preclinical studies have recently evaluated the impact of low-dose brain radiation therapy (LD-RT) in animal models of Alzheimer’s disease (AD) showing anti-amyloid and anti-inflammatory effects of this treatm...

    Authors: Kelly Ceyzériat, Thomas Zilli, Philippe Millet, Nikolaos Koutsouvelis, Giovanna Dipasquale, Christine Fossey, Thomas Cailly, Frédéric Fabis, Giovanni B. Frisoni, Valentina Garibotto and Benjamin B. Tournier
    Citation: Journal of Neuroinflammation 2022 19:311
  38. Long-term use of opioids such as morphine has negative side effects, such as morphine analgesic tolerance and morphine-induced hyperalgesia (MIH). These side effects limit the clinical use and analgesic effica...

    Authors: Handong Ouyang, Jianxing Zhang, Dongmei Chi, Kun Zhang, Yongtian Huang, Jingxiu Huang, Wan Huang and Xiaohui Bai
    Citation: Journal of Neuroinflammation 2022 19:310
  39. Alcohol use disorders result from repeated binge and chronic alcohol consumption followed by negative effects, such as anxiety, upon cessation. This process is associated with the activation of NLRP3 inflammas...

    Authors: Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou and Tengfei Ma
    Citation: Journal of Neuroinflammation 2022 19:308
  40. Zika virus (ZIKV) infection at postnatal or adult age can lead to neurological disorders associated with cognitive defects. Yet, how mature neurons respond to ZIKV remains substantially unexplored.

    Authors: Caroline Manet, Zeyni Mansuroglu, Laurine Conquet, Violaine Bortolin, Thomas Comptdaer, Helena Segrt, Marie Bourdon, Reyene Menidjel, Nicolas Stadler, Guanfang Tian, Floriane Herit, Florence Niedergang, Sylvie Souès, Luc Buée, Marie-Christine Galas, Xavier Montagutelli…
    Citation: Journal of Neuroinflammation 2022 19:307
  41. Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis of CSF can aid the diagnosis ...

    Authors: Frederike Straeten, Jing Zhu, Anna-Lena Börsch, Baohong Zhang, Kejie Li, I-Na Lu, Catharina Gross, Michael Heming, Xiaolin Li, Rebekah Rubin, Zhengyu Ouyang, Heinz Wiendl, Michael Mingueneau and Gerd Meyer zu Hörste
    Citation: Journal of Neuroinflammation 2022 19:306
  42. Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA...

    Authors: Bettina Zierfuss, Agnieszka Buda, Andrea Villoria-González, Maxime Logist, Jure Fabjan, Patricia Parzer, Claire Battin, Streggi Vandersteene, Inge M. E. Dijkstra, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Peter Steinberger, Stephan Kemp, Sonja Forss-Petter, Johannes Berger and Isabelle Weinhofer
    Citation: Journal of Neuroinflammation 2022 19:305
  43. Listeria monocytogenes (Lm) is a bacterial pathogen of major concern for humans and ruminants due to its neuroinvasive potential and its ability to cause deadly encephalitis (neurolisteriosis). On one hand, polym...

    Authors: Stefano Bagatella, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt and Anna Oevermann
    Citation: Journal of Neuroinflammation 2022 19:304
  44. Considerable evidence indicates that a signaling crosstalk between the brain and periphery plays important roles in neurological disorders, and that both acute and chronic peripheral inflammation can produce b...

    Authors: Patrick R. Suman, Lisiane S. Souza, Grasielle C. Kincheski, Helen M. Melo, Mariana N. Machado, Giovanna M. C. Carvalho, Fernanda G. De Felice, Walter A. Zin and Sergio T. Ferreira
    Citation: Journal of Neuroinflammation 2022 19:303
  45. The nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity in multiple neuropathic pain models, but th...

    Authors: Wen Chen, Xiaotong Wang, Qingyu Sun, Yurui Zhang, Jing Liu, Tingting Hu, Weihua Wu, Chao Wei, Meng Liu, Yumeng Ding, Dianxin Liu, Yingzi Chong, Peipei Wang, Hongwei Zhu, Weihua Cui, Jiannan Zhang…
    Citation: Journal of Neuroinflammation 2022 19:302
  46. Microglia-induced excessive neuroinflammation plays a crucial role in the pathophysiology of multiple neurological diseases, such as ischaemic stroke. Controlling inflammatory responses is considered a promisi...

    Authors: Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang and Xing Li
    Citation: Journal of Neuroinflammation 2022 19:301
  47. Microglia, the resident phagocytes of the retina, are believed to influence the development of retinopathy, but their exact contributions to vascular integrity and neuronal loss are unknown. Therefore, utilizi...

    Authors: Kaira A. Church, Derek Rodriguez, Difernando Vanegas, Irene L. Gutierrez, Sandra M. Cardona, José L. M. Madrigal, Tejbeer Kaur and Astrid E. Cardona
    Citation: Journal of Neuroinflammation 2022 19:300
  48. Perioperative neurocognitive disorders (PND) is a common postoperative complication associated with regional or general anesthesia and surgery. Growing evidence in both patient and animal models of PND suggest...

    Authors: Chun Cheng, Hanxi Wan, Peilin Cong, Xinwei Huang, Tingmei Wu, Mengfan He, Qian Zhang, Lize Xiong and Li Tian
    Citation: Journal of Neuroinflammation 2022 19:297

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