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  1. Content type: Research

    Age-related macular degeneration (AMD) is a multifactorial chronic disease of the eye. Several candidate pathways have been hypothesized to play a role in AMD pathogenesis. Our work and those of others suggest...

    Authors: Jiangyuan Gao, Jing Z. Cui, Aikun Wang, Hao Hang Rachel Chen, Alison Fong and Joanne A. Matsubara

    Citation: Journal of Neuroinflammation 2019 16:171

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  2. Content type: Research

    Lysophosphatidic acid receptor 1 (LPA1) is in the spotlight because its synthetic antagonist has been under clinical trials for lung fibrosis and psoriasis. Targeting LPA1 might also be a therapeutic strategy for...

    Authors: Bhakta Prasad Gaire, Arjun Sapkota, Mi-Ryoung Song and Ji Woong Choi

    Citation: Journal of Neuroinflammation 2019 16:170

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  3. Content type: Research

    Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It ...

    Authors: Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott and Gareth R. Howell

    Citation: Journal of Neuroinflammation 2019 16:169

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  4. Content type: Research

    Functions of astrocytes in the rehabilitation after ischemic stroke, especially their impacts on inflammatory processes, remain controversial. This study uncovered two phenotypes of astrocytes, of which one wa...

    Authors: Nan Zhao, Xiaomeng Xu, Yongjun Jiang, Jie Gao, Fang Wang, Xiaohui Xu, Zhuoyu Wen, Yi Xie, Juanji Li, Rongrong Li, Qiushi Lv, Qian Liu, Qiliang Dai, Xinfeng Liu and Gelin Xu

    Citation: Journal of Neuroinflammation 2019 16:168

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  5. Content type: Research

    Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is conside...

    Authors: Judith Derdelinckx, María José Mansilla, Maxime De Laere, Wai-Ping Lee, Juan Navarro-Barriuso, Inez Wens, Irene Nkansah, Jasmijn Daans, Hans De Reu, Aneta Jolanta Keliris, Johan Van Audekerke, Verdi Vanreusel, Zoë Pieters, Annemie Van der Linden, Marleen Verhoye, Geert Molenberghs…

    Citation: Journal of Neuroinflammation 2019 16:167

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  6. Content type: Research

    Currently, there are no effective therapeutic options for Alzheimer’s disease, the most common, multifactorial form of dementia, characterized by anomalous amyloid accumulation in the brain. Growing evidence p...

    Authors: Giulia Di Benedetto, Chiara Burgaletto, Anna R. Carta, Salvatore Saccone, Laurence Lempereur, Giovanna Mulas, Carla Loreto, Renato Bernardini and Giuseppina Cantarella

    Citation: Journal of Neuroinflammation 2019 16:166

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  7. Content type: Research

    The association of gut microbiota and diseases of the central nervous system (CNS), including multiple sclerosis (MS), has attracted much attention. Although a previous analysis of MS gut microbiota revealed a...

    Authors: Tong Chen, Daisuke Noto, Yasunobu Hoshino, Miho Mizuno and Sachiko Miyake

    Citation: Journal of Neuroinflammation 2019 16:165

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  8. Content type: Research

    Astrocytes respond to central nervous system (CNS) injury and disease by transforming to a reactive astrogliosis cell state that can contribute to either CNS dysfunction or repair. Neuroinflammation is a power...

    Authors: Qiong Zhou, Coralie Viollet, Anastasia Efthymiou, Guzal Khayrullina, Kasey E. Moritz, Matthew D. Wilkerson, Gauthaman Sukumar, Clifton L. Dalgard and Martin L. Doughty

    Citation: Journal of Neuroinflammation 2019 16:164

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  9. Content type: Research

    Traumatic brain injury (TBI) is a major cause of death and disability. T cells were shown to infiltrate the brain during the first days after injury and to exacerbate tissue damage. The objective of this study...

    Authors: Tobias J. Krämer, Nathalia Hack, Till J. Brühl, Lutz Menzel, Regina Hummel, Eva-Verena Griemert, Matthias Klein, Serge C. Thal, Tobias Bopp and Michael K. E. Schäfer

    Citation: Journal of Neuroinflammation 2019 16:163

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  10. Content type: Research

    The spectrum of classical and non-classical HLA genes related to the risk of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) in the Japanese population has not been studied in detail...

    Authors: Kotaro Ogawa, Tatsusada Okuno, Kazuyoshi Hosomichi, Akiko Hosokawa, Jun Hirata, Ken Suzuki, Saori Sakaue, Makoto Kinoshita, Yoshihiro Asano, Katsuichi Miyamoto, Ituro Inoue, Susumu Kusunoki, Yukinori Okada and Hideki Mochizuki

    Citation: Journal of Neuroinflammation 2019 16:162

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  11. Content type: Research

    Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). It is firmly established that overactivation of the p65 (RelA) nuclear factor kappa B (NF-κB) transcription f...

    Authors: Angela S. Gupta, Debolina D. Biswas, La Shardai N. Brown, Karli Mockenhaupt, Michael Marone, Andrew Hoskins, Ulrich Siebenlist and Tomasz Kordula

    Citation: Journal of Neuroinflammation 2019 16:161

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  12. Content type: Research

    Spinal cord injury (SCI) is a catastrophic trauma accompanied by intralesional bleeding and neuroinflammation. Recently, there is increasing interest in tranexamic acid (TXA), an anti-fibrinolytic drug, which ...

    Authors: Shingo Yoshizaki, Ken Kijima, Masamitsu Hara, Takeyuki Saito, Tetsuya Tamaru, Masatake Tanaka, Dai-jiro Konno, Yasuharu Nakashima and Seiji Okada

    Citation: Journal of Neuroinflammation 2019 16:160

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  13. Content type: Research

    It has become increasingly evident that the immune and nervous systems are closely intertwined, relying on one another during regular homeostatic conditions. Prolonged states of imbalance between neural and im...

    Authors: Timothy French, Henning Peter Düsedau, Johannes Steffen, Aindrila Biswas, Norus Ahmed, Susanne Hartmann, Thomas Schüler, Björn H. Schott and Ildiko Rita Dunay

    Citation: Journal of Neuroinflammation 2019 16:159

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  14. Content type: Research

    Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination. Studies indicate that Toll-like receptor 2 (TLR2) signa...

    Authors: Nicholas J. Wasko, Meghan Horne Kulak, Debayon Paul, Alexandra M. Nicaise, Stephen T. Yeung, Frank C. Nichols, Kamal M. Khanna, Stephen Crocker, Joel S. Pachter and Robert B. Clark

    Citation: Journal of Neuroinflammation 2019 16:158

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  15. Content type: Research

    To decipher the role of monocyte-derived macrophages (Mφs) in vascular remodeling of the occluded vein following experimental branch retinal vein occlusion (BRVO).

    Authors: Christophe Roubeix, Elisa Dominguez, William Raoul, Xavier Guillonneau, Michel Paques, José-Alain Sahel and Florian Sennlaub

    Citation: Journal of Neuroinflammation 2019 16:157

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  16. Content type: Research

    Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced b...

    Authors: Lukas Muri, Ngoc Dung Le, Jonas Zemp, Denis Grandgirard and Stephen L. Leib

    Citation: Journal of Neuroinflammation 2019 16:156

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  17. Content type: Research

    Magnetic resonance imaging (MRI)-guided pulsed focused ultrasound combined with the infusion of microbubbles (pFUS+MB) induces transient blood-brain barrier opening (BBBO) in targeted regions. pFUS+MB, through...

    Authors: Sanhita Sinharay, Tsang-Wei Tu, Zsofia I. Kovacs, William Schreiber-Stainthorp, Maggie Sundby, Xiang Zhang, Georgios Z. Papadakis, William C. Reid, Joseph A. Frank and Dima A. Hammoud

    Citation: Journal of Neuroinflammation 2019 16:155

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  18. Content type: Research

    Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only in...

    Authors: Frederike C. Oertel, Olivier Outteryck, Benjamin Knier, Hanna Zimmermann, Nadja Borisow, Judith Bellmann-Strobl, Astrid Blaschek, Sven Jarius, Markus Reindl, Klemens Ruprecht, Edgar Meinl, Reinhard Hohlfeld, Friedemann Paul, Alexander U. Brandt, Tania Kümpfel and Joachim Havla

    Citation: Journal of Neuroinflammation 2019 16:154

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  19. Content type: Research

    In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting ...

    Authors: Ana Beatriz DePaula-Silva, Carlos Gorbea, Daniel J. Doty, Jane E. Libbey, John Michael S. Sanchez, Tyler J. Hanak, Demián Cazalla and Robert S. Fujinami

    Citation: Journal of Neuroinflammation 2019 16:152

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  20. Content type: Research

    Microglia are essential to the development of the CNS and its homeostasis. Our prior findings suggested a niche model to describe the behaviors of retinal microglia. Here, we ask whether new myeloid cells recr...

    Authors: Scott W. McPherson, Neal D. Heuss, Ute Lehmann, Heidi Roehrich, Md. Abedin and Dale S. Gregerson

    Citation: Journal of Neuroinflammation 2019 16:151

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  21. Content type: Research

    Determining the etiology and possible treatment strategies for numerous diseases requires a comprehensive understanding of compensatory mechanisms in physiological systems. The vagus nerve acts as a key interf...

    Authors: Anna Kobrzycka, Paweł Napora, Brandon L. Pearson, Krystyna Pierzchała-Koziec, Rafał Szewczyk and Marek Wieczorek

    Citation: Journal of Neuroinflammation 2019 16:150

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  22. Content type: Research

    Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-rela...

    Authors: Yan-Hua Li, Fang Xu, Rodolfo Thome, Min-Fang Guo, Man-Luan Sun, Guo-Bin Song, Rui-lan Li, Zhi Chai, Bogoljub Ciric, A. M. Rostami, Mark Curtis, Cun-Gen Ma and Guang-Xian Zhang

    Citation: Journal of Neuroinflammation 2019 16:149

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  23. Content type: Research

    Neuroinflammation is the response of the central nervous system to events that interfere with tissue homeostasis and represents a common denominator in virtually all neurological diseases. Activation of microg...

    Authors: Morena Zusso, Valentina Lunardi, Davide Franceschini, Andrea Pagetta, Rita Lo, Stefano Stifani, Anna Chiara Frigo, Pietro Giusti and Stefano Moro

    Citation: Journal of Neuroinflammation 2019 16:148

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  24. Content type: Research

    Neurotoxocarosis (NT) is induced by larvae of the dog or cat roundworm (Toxocara canis or T. cati) migrating and persisting in the central nervous system of paratenic hosts, including humans, and may be accompani...

    Authors: Patrick Waindok and Christina Strube

    Citation: Journal of Neuroinflammation 2019 16:147

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  25. Content type: Research

    The small population of glioma stem-like cells (GSCs) contributes to tumor initiation, malignancy, and recurrence in glioblastoma. However, the maintenance of GSC properties in the tumor microenvironment remai...

    Authors: Shao-Ming Wang, Hong-Yi Lin, Yen-Lin Chen, Tsung-I Hsu, Jian-Ying Chuang, Tzu-Jen Kao and Chiung-Yuan Ko

    Citation: Journal of Neuroinflammation 2019 16:146

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  26. Content type: Short report

    Increased plasma YKL-40 has been reported in Alzheimer’s disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegene...

    Authors: Anna Villar-Piqué, Matthias Schmitz, Peter Hermann, Stefan Goebel, Timothy Bunck, Daniela Varges, Isidre Ferrer, Joachim Riggert, Franc Llorens and Inga Zerr

    Citation: Journal of Neuroinflammation 2019 16:145

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  27. Content type: Research

    Cardiovascular exercise (CVE) has been shown to be protective against cognitive decline in aging and the risk for dementias, including Alzheimer’s Disease (AD). CVE has also been shown to have several benefici...

    Authors: Lisa S. Robison, Dominique L. Popescu, Maria E. Anderson, Nikita Francis, Joshua Hatfield, Joseph K. Sullivan, Steven I. Beigelman, Feng Xu, Brenda J. Anderson, William E. Van Nostrand and John K. Robinson

    Citation: Journal of Neuroinflammation 2019 16:144

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  28. Content type: Research

    Alzheimer’s disease (AD) is a neuropathology strongly associated with the activation of inflammatory pathways. Accordingly, inflammation resulting from obesity exacerbates learning and memory deficits in human...

    Authors: Elisa Medrano-Jiménez, Itzia Jiménez-Ferrer Carrillo, Martha Pedraza-Escalona, Cristina E. Ramírez-Serrano, Lourdes Álvarez-Arellano, Javier Cortés-Mendoza, Maribel Herrera-Ruiz, Enrique Jiménez-Ferrer, Alejandro Zamilpa, Jaime Tortoriello, Gustavo Pedraza-Alva and Leonor Pérez-Martínez

    Citation: Journal of Neuroinflammation 2019 16:143

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  29. Content type: Review

    Stroke, the third leading cause of death and disability worldwide, is undergoing a change in perspective with the emergence of new ideas on neurodegeneration. The concept that stroke is a disorder solely of bl...

    Authors: Richard L. Jayaraj, Sheikh Azimullah, Rami Beiram, Fakhreya Y. Jalal and Gary A. Rosenberg

    Citation: Journal of Neuroinflammation 2019 16:142

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  30. Content type: Research

    Spinal cord injury (SCI) is a condition with few effective treatment options. The blood-spinal cord barrier consists of pericytes, astrocytes, and endothelial cells, which are collectively termed the neurovasc...

    Authors: Jonathon Chon Teng Chio, Jian Wang, Anna Badner, James Hong, Vithushan Surendran and Michael G. Fehlings

    Citation: Journal of Neuroinflammation 2019 16:141

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  31. Content type: Review

    Chronic pain is a critical clinical problem with an increasing prevalence. However, there are limited effective prevention measures and treatments for chronic pain. Astrocytes are the most abundant glial cells...

    Authors: Ting Li, Xuhui Chen, Chuanhan Zhang, Yue Zhang and Wenlong Yao

    Citation: Journal of Neuroinflammation 2019 16:140

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  32. Content type: Research

    Sympathetic overactivation and inflammation are two major mediators to post-myocardial ischemia-reperfusion (I/R)-induced ventricular arrhythmia (VA). The vicious cycle between microglia and sympathetic activa...

    Authors: Songyun Wang, Lin Wu, Xuemeng Li, Binxun Li, Yi Zhai, Dongdong Zhao and Hong Jiang

    Citation: Journal of Neuroinflammation 2019 16:139

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  33. Content type: Research

    Leukostasis is a key patho-physiological event responsible for capillary occlusion in diabetic retinopathy. Circulating monocytes are the main cell type entrapped in retinal vessels in diabetes. In this study,...

    Authors: Mei Chen, Gideon Obasanmi, David Armstrong, Nuala-Jane Lavery, Adrien Kissenpfennig, Noemi Lois and Heping Xu

    Citation: Journal of Neuroinflammation 2019 16:138

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  34. Content type: Research

    The lack of effective treatment for Alzheimer’s disease (AD) stems mainly from the incomplete understanding of AD causes. Neuroinflammation has emerged as an important component of AD pathology, and a vast num...

    Authors: Marta Sochocka, Michał Ochnik, Maciej Sobczyński, Iwona Siemieniec, Beata Orzechowska, Piotr Naporowski and Jerzy Leszek

    Citation: Journal of Neuroinflammation 2019 16:137

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  35. Content type: Research

    Current evidence indicates that extracellular vesicles (EVs) participate in intercellular signaling, and in the regulation and amplification of neuroinflammation. We have previously shown that ethanol activate...

    Authors: Francesc Ibáñez, Jorge Montesinos, Juan R. Ureña-Peralta, Consuelo Guerri and María Pascual

    Citation: Journal of Neuroinflammation 2019 16:136

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  36. Content type: Research

    Treatments for autoimmune diseases aim to dampen autoreactivity while preserving normal immune function. In CD4+ T cells, the transcription factor Oct1/Pou2f1 is a dispensable transcription factor for T cell deve...

    Authors: Heejoo Kim, Laura Dickey, Colleen Stone, Jillian L. Jafek, Thomas E. Lane and Dean Tantin

    Citation: Journal of Neuroinflammation 2019 16:133

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  37. Content type: Research

    Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are related to several acquired demyelinating syndromes in adults, but the therapeutic approach is currently unclear. We aimed to describe the response t...

    Authors: Alvaro Cobo-Calvo, María Sepúlveda, Fabien Rollot, Thais Armangué, Anne Ruiz, Elisabeth Maillart, Caroline Papeix, Bertrand Audoin, Helene Zephir, Damien Biotti, Jonathan Ciron, Francoise Durand-Dubief, Nicolas Collongues, Xavier Ayrignac, Pierre Labauge, Eric Thouvenot…

    Citation: Journal of Neuroinflammation 2019 16:134

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  38. Content type: Research

    Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epige...

    Authors: Yu-Jiao Li, Kun Zhang, Ting Sun, Jian Wang, Yan-Yan Guo, Le Yang, Qi Yang, Yan-Jiao Li, Shui-Bing Liu, Ming-Gao Zhao and Yu-Mei Wu

    Citation: Journal of Neuroinflammation 2019 16:132

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  39. Content type: Research

    An alteration of autophagy and mitophagy, two highly conserved lysosome-dependent degradation pathways involved in the maintenance of cellular homeostasis, has been associated with multiple sclerosis (MS).

    Authors: Massimiliano Castellazzi, Simone Patergnani, Mariapina Donadio, Carlotta Giorgi, Massimo Bonora, Enrico Fainardi, Ilaria Casetta, Enrico Granieri, Maura Pugliatti and Paolo Pinton

    Citation: Journal of Neuroinflammation 2019 16:131

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  40. Content type: Research

    Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms of disease pathogenes...

    Authors: Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries and Yvette van Kooyk

    Citation: Journal of Neuroinflammation 2019 16:130

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  41. Content type: Research

    Emerging evidence suggests that gut microbiome composition alterations affect neurodegeneration through neuroinflammation in the pathogenesis of Parkinson’s disease (PD). Here, we evaluate gut microbiota alter...

    Authors: Chin-Hsien Lin, Chieh-Chang Chen, Han-Lin Chiang, Jyh-Ming Liou, Chih-Min Chang, Tzu-Pin Lu, Eric Y. Chuang, Yi-Cheng Tai, Chieh Cheng, Han-Yi Lin and Ming-Shiang Wu

    Citation: Journal of Neuroinflammation 2019 16:129

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  42. Content type: Research

    Synaptic dysfunction, named synaptopathy, due to inflammatory status of the central nervous system (CNS) is a recognized factor potentially underlying both motor and cognitive dysfunctions in neurodegenerative...

    Authors: Vincenzo Giacco, Giulia Panattoni, Manuela Medelin, Elena Bonechi, Alessandra Aldinucci, Clara Ballerini and Laura Ballerini

    Citation: Journal of Neuroinflammation 2019 16:127

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  43. Content type: Research

    Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combine...

    Authors: Gabriella Contarini, Davide Franceschini, Laura Facci, Massimo Barbierato, Pietro Giusti and Morena Zusso

    Citation: Journal of Neuroinflammation 2019 16:126

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  44. Content type: Research

    Lipopolysaccharide (LPS)-induced systemic inflammation (SI) is associated with neuroinflammation in the brain, hypotension, tachycardia, and multiple organs dysfunctions. Considering that during SI these impor...

    Authors: Mateus R. Amorim, Júnia L. de Deus, Rafael A. Cazuza, Clarissa M. D. Mota, Luiz E. V. da Silva, Gabriela S. Borges, Marcelo E. Batalhão, Evelin C. Cárnio and Luiz G. S. Branco

    Citation: Journal of Neuroinflammation 2019 16:125

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  45. Content type: Research

    Spinal cord injury (SCI) usually causes a devastating lifelong disability for patients. After a traumatic lesion, disruption of the blood-spinal cord barrier induces the infiltration of macrophages into the le...

    Authors: Judith Sánchez-Ventura, Jesús Amo-Aparicio, Xavier Navarro and Clara Penas

    Citation: Journal of Neuroinflammation 2019 16:124

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  46. Content type: Research

    Astrocyte activation is a common pathological feature in many brain diseases with neuroinflammation, and revealing the underlying mechanisms might shed light on the regulatory processes of the diseases. Recent...

    Authors: Chia-Chi Hung, Yi-Hsuan Lee, Yi-Min Kuo, Pei-Chien Hsu, Huey-Jen Tsay, Ying-Ting Hsu, Chih-Chin Lee, Jia-Jun Liang and Feng-Shiun Shie

    Citation: Journal of Neuroinflammation 2019 16:123

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