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  1. Autoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to affect the course of autoimmune diseases. Intestinal microorganisms ca...

    Authors: Yuting Meng, Xiangjie Qiu, Zhongxiang Tang, Yu Mao and Yurong Tan
    Citation: Journal of Neuroinflammation 2023 20:122
  2. Hepatic encephalopathy-induced hyperammonemia alters astrocytic glutamate metabolism in the brain, which is involved in cognitive decline. To identify specific therapeutic strategies for the treatment of hepat...

    Authors: Danbi Jo, Yeong-Hwan Lim, Yoon Seok Jung, Young-Kook Kim and Juhyun Song
    Citation: Journal of Neuroinflammation 2023 20:121
  3. Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal s...

    Authors: Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani and Jeremías G. Galletti
    Citation: Journal of Neuroinflammation 2023 20:120
  4. Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal do...

    Authors: Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li and Lili Gong
    Citation: Journal of Neuroinflammation 2023 20:119
  5. Blood–spinal cord barrier (BSCB) disruption is a key event after spinal cord injury (SCI), which permits unfavorable blood-derived substances to enter the neural tissue and exacerbates secondary injury. Howeve...

    Authors: Rubing Zhou, Junzhao Li, Zhengyang Chen, Ruideng Wang, Yin Shen, Rong Zhang, Fang Zhou and Yong Zhang
    Citation: Journal of Neuroinflammation 2023 20:118
  6. New data are accumulating on gut microbial dysbiosis in Parkinson’s disease (PD), while the specific mechanism remains uncharacterized. This study aims to investigate the potential role and pathophysiological ...

    Authors: Jianjun Yu, Jianhong Meng, Zhengwei Qin, Yuan Yu, Yingxin Liang, Yanjun Wang and Dongmei Min
    Citation: Journal of Neuroinflammation 2023 20:117
  7. Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzh...

    Authors: Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner and Charbel Moussa
    Citation: Journal of Neuroinflammation 2023 20:116
  8. Microglial polarization is one of the most promising therapeutic targets for multiple central nervous system (CNS) disorders, including ischemic stroke. However, detailed transcriptional alteration of microgli...

    Authors: Yueman Zhang, Yunlu Guo, Ruqi Li, Tingting Huang, Yan Li, Wanqin Xie, Chen Chen, Weijie Chen, Jieqing Wan, Weifeng Yu and Peiying Li
    Citation: Journal of Neuroinflammation 2023 20:115
  9. Treatment of brain tumors, epilepsy, or hemodynamic abnormalities requires a craniotomy to access the brain. Nearly 1 million craniotomies are performed in the US annually, which increase to ~ 14 million world...

    Authors: Gunjan Kak, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Wen Shi, Axel Roers, Bin Duan and Tammy Kielian
    Citation: Journal of Neuroinflammation 2023 20:114
  10. Postoperative delirium (POD) is a frequent and debilitating complication, especially amongst high risk procedures, such as orthopedic surgery. This kind of neurocognitive disorder negatively affects cognitive ...

    Authors: Fuzhou Hua, Hong Zhu, Wen Yu, Qingcui Zheng, Lieliang Zhang, Weidong Liang, Yue Lin, Fan Xiao, Pengcheng Yi, Yanhong Xiong, Yao Dong, Hua Li, Lanran Fang, Hailin Liu, Jun Ying and Xifeng Wang
    Citation: Journal of Neuroinflammation 2023 20:113
  11. Numerous studies have found that inhibiting the expression of NLRP3 inflammasome can significantly improve depressive-like behaviors in mice, but the research on its effect on cognitive decline in depression a...

    Authors: Jia-Mei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jia-Hui Guo, Min-Yuan Wang, Yi-Lin Wu, Wen-Jun Su and Chun-Lei Jiang
    Citation: Journal of Neuroinflammation 2023 20:112
  12. Chronically dysregulated neuroinflammation has been implicated in neurodegenerative dementias, with separate studies reporting increased brain levels of inflammatory mediators and gliosis in Alzheimer’s diseas...

    Authors: Yuek Ling Chai, Jasinda H. Lee, Joyce R. Chong, Clive Ballard, Paul T. Francis, Brian K. Kennedy, Thiruma V. Arumugam, Christopher P. Chen, Dag Aarsland and Mitchell K. P. Lai
    Citation: Journal of Neuroinflammation 2023 20:111
  13. Depression and dysosmia have been regarded as primary neurological symptoms in COVID-19 patients, the mechanism of which remains unclear. Current studies have demonstrated that the SARS-CoV-2 envelope (E) prot...

    Authors: Wenliang Su, Jiahang Ju, Minghui Gu, Xinrui Wang, Shaozhuang Liu, Jiawen Yu and Dongliang Mu
    Citation: Journal of Neuroinflammation 2023 20:110
  14. Complex regional pain syndrome type-I (CRPS-I) causes excruciating pain that affect patients’ life quality. However, the mechanisms underlying CRPS-I are incompletely understood, which hampers the development ...

    Authors: Jie Wang, Chengyu Yin, Yushuang Pan, Yunqin Yang, Wei Li, Huadong Ni, Boyu Liu, Huimin Nie, Ruoyao Xu, Huina Wei, Yunwen Zhang, Yuanyuan Li, Qimiao Hu, Yan Tai, Xiaomei Shao, Jianqiao Fang…
    Citation: Journal of Neuroinflammation 2023 20:109
  15. Frontotemporal dementia (FTD) is a heterogeneous group of early onset and progressive neurodegenerative disorders, characterized by degeneration in the frontal and temporal lobes, which causes deterioration in...

    Authors: Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz and Eva de Lago
    Citation: Journal of Neuroinflammation 2023 20:108
  16. There is a need for novel fluid biomarkers tracking neuroinflammatory responses in Alzheimer’s disease (AD). Our recent cerebrospinal fluid (CSF) proteomics study revealed that migration inhibitory factor (MIF...

    Authors: Yanaika S. Hok-A-Hin, Marta del Campo, Walter A. Boiten, Erik Stoops, Melanie Vanhooren, Afina W. Lemstra, Wiesje M. van der Flier and Charlotte E. Teunissen
    Citation: Journal of Neuroinflammation 2023 20:107
  17. TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs...

    Authors: Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman and Ulrich L. M. Eisel
    Citation: Journal of Neuroinflammation 2023 20:106
  18. Chronic cerebral ischemia induces white matter injury (WMI) contributing to cognitive decline. Both astrocytes and microglia play vital roles in the demyelination and remyelination processes, but the underlyin...

    Authors: Qian Cao, Jian Chen, Zhi Zhang, Shu Shu, Yi Qian, Lixuan Yang, Lushan Xu, Yuxin Zhang, Xinyu Bao, Shengnan Xia, Haiyan Yang, Yun Xu and Shuwei Qiu
    Citation: Journal of Neuroinflammation 2023 20:105
  19. Increasing pre-clinical evidence suggests that aerobic exercise positively modulates neuroimmune responses following traumatic nerve injury. However, meta-analyses on neuroimmune outcomes are currently still l...

    Authors: Marije L. S. Sleijser-Koehorst, Meghan A. Koop, Michel W. Coppieters, Ivo J. Lutke Schipholt, Nemanja Radisic, Carlijn R. Hooijmans and Gwendolyne G. M. Scholten-Peeters
    Citation: Journal of Neuroinflammation 2023 20:104
  20. Authors: Shufen Chen, Jens Martens-Lobenhoffer, Karin Weissenborn, Jan T. Kielstein, Ralf Lichtinghagen, Milani Deb-Chatterji, Na Li, Anita B. Tryc, Annemarie Goldbecker, Qiang Dong, Stefanie M. Bode-Böger and Hans Worthmann
    Citation: Journal of Neuroinflammation 2023 20:103

    The original article was published in Journal of Neuroinflammation 2012 9:251

  21. Postoperative pain and inflammation are significant complications following surgery. Strategies that aim to prevent excessive inflammation without hampering natural wound-healing are required for the managemen...

    Authors: Kazuha Mitsui, Sohei Hishiyama, Aakanksha Jain, Yumi Kotoda, Masako Abe, Takashi Matsukawa and Masakazu Kotoda
    Citation: Journal of Neuroinflammation 2023 20:102
  22. Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an innate immune modulator, is stron...

    Authors: Nan Li, Chunyan Wang, Yuying Zhao, Yigang Wang, Tianyu Gao, Yonghao Yu, Guolin Wang and Linlin Zhang
    Citation: Journal of Neuroinflammation 2023 20:101
  23. Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of the...

    Authors: Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem and Sarah K. Williams
    Citation: Journal of Neuroinflammation 2023 20:100
  24. Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin). p21-acti...

    Authors: Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim and Tae-Cheon Kang
    Citation: Journal of Neuroinflammation 2023 20:99
  25. Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester o...

    Authors: Alberto Zenere, Sandra Hellberg, Georgia Papapavlou Lingehed, Maria Svenvik, Johan Mellergård, Charlotte Dahle, Magnus Vrethem, Johanna Raffetseder, Mohsen Khademi, Tomas Olsson, Marie Blomberg, Maria C. Jenmalm, Claudio Altafini, Mika Gustafsson and Jan Ernerudh
    Citation: Journal of Neuroinflammation 2023 20:98
  26. Ischemic stroke is characterized by the presence of reactive microglia. However, its precise involvement in stroke etiology is still unknown. We used metabolic profiling and showed that chemokine like factor 1...

    Authors: Wen-yu Ma, Qing-lin Wu, Sha-sha Wang, Hong-yun Wang, Jun-rui Ye, Hong-shuo Sun, Zhong-ping Feng, Wen-bin He, Shi-feng Chu, Zhao Zhang and Nai-hong Chen
    Citation: Journal of Neuroinflammation 2023 20:97
  27. Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation mediated by overactivated microglia a...

    Authors: Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei…
    Citation: Journal of Neuroinflammation 2023 20:96
  28. Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions, while they can sustain neuroinflammatory and neurotoxic processes i...

    Authors: Frida Lind-Holm Mogensen, Andrea Scafidi, Aurélie Poli and Alessandro Michelucci
    Citation: Journal of Neuroinflammation 2023 20:95
  29. The cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are invasive or imprecise. Noninvasive low-intensity pulsed ultrasound (L...

    Authors: Tianshu Liu, Yanan Fu, Jiawei Shi, Shukun He, Dandan Chen, Wenqu Li, Yihan Chen, Li Zhang, Qing Lv, Yali Yang, Qiaofeng Jin, Jing Wang and Mingxing Xie
    Citation: Journal of Neuroinflammation 2023 20:94
  30. Peripheral inflammation is an important feature of Parkinson’s disease (PD). However, if and how CNS pathology is involved in the peripheral inflammation in PD remains to be fully investigated. Recently, the e...

    Authors: Zongran Liu, Yang Huang, Xuejing Wang, Jia-Yi Li, Can Zhang, Ying Yang and Jing Zhang
    Citation: Journal of Neuroinflammation 2023 20:93
  31. Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as diagnostic tools or to monitor progression and/or p...

    Authors: Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, Diego Gómez-Nicola, V. Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A. Parker and Diana Cash
    Citation: Journal of Neuroinflammation 2023 20:92
  32. Retinal ischemia–reperfusion (RIR) injury refers to an obstruction in the retinal blood supply followed by reperfusion. Although the molecular mechanism underlying the ischemic pathological cascade is not full...

    Authors: Yunhong Shi, Yidan Liu, Caiqing Wu, Xiuxing Liu, Wenfei Hu, Zhenlan Yang, Zhidong Li, Yangyang Li, Caibin Deng, Kun Wei, Chenyang Gu, Xuhao Chen, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2023 20:91
  33. Neuroinflammation has been suggested as a contributor to the pathophysiology of depression; however, large case–control studies investigating cytokine levels in the cerebrospinal fluid (CSF) from patients with...

    Authors: Nina Vindegaard Sørensen, Nis Borbye-Lorenzen, Rune Haubo Bojesen Christensen, Sonja Orlovska-Waast, Rose Jeppesen, Kristin Skogstrand and Michael Eriksen Benros
    Citation: Journal of Neuroinflammation 2023 20:90
  34. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are activated and play a pivotal role ...

    Authors: Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian and Chuan Qin
    Citation: Journal of Neuroinflammation 2023 20:89
  35. Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking. Autoantibodies against sept...

    Authors: Ramona Miske, Madeleine Scharf, Kathrin Borowski, Nicole Rieckhoff, Bianca Teegen, Yvonne Denno, Christian Probst, Kersten Guthke, Ieva Didrihsone, Brigitte Wildemann, Klemens Ruprecht, Lars Komorowski and Sven Jarius
    Citation: Journal of Neuroinflammation 2023 20:88
  36. Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology. Here, we report th...

    Authors: Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang and Hong Cao
    Citation: Journal of Neuroinflammation 2023 20:87
  37. Previous studies have shown a close association between an altered immune system and Parkinson's disease (PD). Neuroinflammation inhibition may be an effective measure to prevent PD. Recently, numerous reports...

    Authors: Dewei He, Shoupeng Fu, Bojian Ye, Hefei Wang, Yuan He, Zhe Li, Jie Li, Xiyu Gao and Dianfeng Liu
    Citation: Journal of Neuroinflammation 2023 20:86
  38. Recent literature on multiple sclerosis (MS) demonstrates the growing implementation of optical coherence tomography–angiography (OCT-A) to discover potential qualitative and quantitative changes in the retina...

    Authors: Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi, J. Fernando Arevalo, Steven L. Galetta, Hamid Harandi, Elliot M. Frohman, Teresa C. Frohman, Shiv Saidha, Neda Sattarnezhad and Friedemann Paul
    Citation: Journal of Neuroinflammation 2023 20:85
  39. Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems. The hypothesis of monoamine neu...

    Authors: Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei and Ling Zhao
    Citation: Journal of Neuroinflammation 2023 20:84
  40. Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the central nervous system (CNS). Although studies have demonstrated that microglia facilitate remyelination in demyelinating diseas...

    Authors: Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang and Jun Wang
    Citation: Journal of Neuroinflammation 2023 20:83
  41. Central post-stroke pain (CPSP) is an intractable and disabling central neuropathic pain that severely affects patients’ lives, well-being, and socialization abilities. However, CPSP has been poorly studied me...

    Authors: Zhong-Mou Shi, Jun-Jie Jing, Zheng-Jie Xue, Wen-Jun Chen, Yan-Bin Tang, Du-Juan Chen, Xin-Yi Qi, Li Huang, Yi-Qing Zou, Xiao-Zhi Wu and Fei Yang
    Citation: Journal of Neuroinflammation 2023 20:82
  42. Long-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior cingulate cortex (ACC) has been demonstrated to be associated with pain and...

    Authors: Dan-dan Long, Yu-zhuo Zhang, An Liu, Liang Shen, Hong-rui Wei, Qian-qian Lou, Shan-shan Hu, Dan-yang Chen, Xiao-qing Chai and Di Wang
    Citation: Journal of Neuroinflammation 2023 20:81
  43. The unique intracranial tumor microenvironment (TME) contributes to the immunotherapy failure for glioblastoma (GBM), thus new functional protein targets are urgently needed. Alternative splicing is a widespre...

    Authors: Bowen Ni, Guanglong Huang, Runwei Yang, Ziyu Wang, Haimin Song, Kaishu Li, Yunxiao Zhang, Kezhi Wu, Guangwei Shi, Xiran Wang, Jie Shen and Yawei Liu
    Citation: Journal of Neuroinflammation 2023 20:80
  44. Neuroinflammation has been suggested as a pathogenetic mechanism contributing to Parkinson’s disease (PD). However, anti-inflammatory treatment strategies have not yet been established as a therapeutic option ...

    Authors: Alexander Grotemeyer, Judith F. Fischer, James B. Koprich, Jonathan M. Brotchie, Robert Blum, Jens Volkmann and Chi Wang Ip
    Citation: Journal of Neuroinflammation 2023 20:79
  45. Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches. We study the major histocompa...

    Authors: Season K. Wyatt-Johnson, Holly N. Kersey, Juan F. Codocedo, Kathy L. Newell, Gary E. Landreth, Bruce T. Lamb, Adrian L. Oblak and Randy R. Brutkiewicz
    Citation: Journal of Neuroinflammation 2023 20:78
  46. Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clin...

    Authors: Brittney R. Lins, Chidozie C. Anyaegbu, Sarah C. Hellewell, Melissa Papini, Terence McGonigle, Luca De Prato, Matthew Shales and Melinda Fitzgerald
    Citation: Journal of Neuroinflammation 2023 20:77
  47. Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study...

    Authors: Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi and Hao Fang
    Citation: Journal of Neuroinflammation 2023 20:75
  48. Naturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as apoptotic and necrotic cells. However, NAbs pathological relevance in Alzh...

    Authors: Dongmei Gu, Luchun Wang, Nan Zhang, Huali Wang and Xin Yu
    Citation: Journal of Neuroinflammation 2023 20:74
  49. The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To provide novel insights into the roles of astrocytes in the pathop...

    Authors: Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent and Marie-Ève Tremblay
    Citation: Journal of Neuroinflammation 2023 20:73

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