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  1. The RING domain-containing protein RING finger protein 11 (RNF11) is a member of the A20 ubiquitin-editing protein complex and modulates peripheral NF-κB signaling. RNF11 is robustly expressed in neurons and c...

    Authors: Elaine L Pranski, Nirjari V Dalal, Jeremy H Herskowitz, Adam L Orr, Leah A Roesch, Jason J Fritz, Craig Heilman, James J Lah, Allan I Levey and Ranjita S Betarbet
    Citation: Journal of Neuroinflammation 2012 9:67
  2. Emerging data implicate nicotinamide phosphoribosyl transferase (NAMPT) in the pathogenesis of cancer and inflammation. NAMPT inhibitors have proven beneficial in inflammatory animal models of arthritis and en...

    Authors: Emanuela Esposito, Daniela Impellizzeri, Emanuela Mazzon, Gohar Fakhfouri, Reza Rahimian, Cristina Travelli, Gian Cesare Tron, Armando A Genazzani and Salvatore Cuzzocrea
    Citation: Journal of Neuroinflammation 2012 9:66
  3. Microglia and macrophages (MG/MΦ) have a diverse range of functions depending on unique cytokine stimuli, and contribute to neural cell death, repair, and remodeling during central nervous system diseases. Whi...

    Authors: Atsushi Sato, Hirokazu Ohtaki, Tomomi Tsumuraya, Dandan Song, Kenji Ohara, Masahide Asano, Yoichiro Iwakura, Takashi Atsumi and Seiji Shioda
    Citation: Journal of Neuroinflammation 2012 9:65
  4. Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs). We reported previously that blocking EMMPRIN activity reduc...

    Authors: Smriti M Agrawal, Claudia Silva, Janet Wang, Jade Pui-Wai Tong and V Wee Yong
    Citation: Journal of Neuroinflammation 2012 9:64
  5. Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen per...

    Authors: Elizabeth Gray, Mark Ginty, Kevin Kemp, Neil Scolding and Alastair Wilkins
    Citation: Journal of Neuroinflammation 2012 9:63
  6. A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory r...

    Authors: Maria Teresa Ferretti, Simon Allard, Vanessa Partridge, Adriana Ducatenzeiler and A Claudio Cuello
    Citation: Journal of Neuroinflammation 2012 9:62
  7. Mice with peroxisome deficiency in neural cells (Nestin-Pex5 −/− ) develop a neurodegenerative phenotype leading to mo...

    Authors: Astrid Bottelbergs, Simon Verheijden, Paul P Van Veldhoven, Wilhelm Just, Rita Devos and Myriam Baes
    Citation: Journal of Neuroinflammation 2012 9:61
  8. The extent to which susceptibility to brain hemorrhage is derived from blood-derived factors or stromal tissue remains largely unknown. We have developed an inducible model of CD8 T cell-initiated blood-brain ...

    Authors: Holly L Johnson, Yi Chen, Georgette L Suidan, Jeremiah R McDole, Anne K Lohrey, Lisa M Hanson, Fang Jin, Istvan Pirko and Aaron J Johnson
    Citation: Journal of Neuroinflammation 2012 9:60
  9. Prions, composed of a misfolded protein designated PrPSc, are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomye...

    Authors: Yael Friedman-Levi, Romana Hoftberger, Herbert Budka, Tehila Mayer-Sonnenfeld, Oded Abramsky, Haim Ovadia and Ruth Gabizon
    Citation: Journal of Neuroinflammation 2012 9:58
  10. Neuroinflammation occurs as a result of microglial activation in response to invading micro-organisms or other inflammatory stimuli within the central nervous system. According to our earlier findings, Krüppel...

    Authors: Deepak Kumar Kaushik, Rupanjan Mukhopadhyay, Kanhaiya Lal Kumawat, Malvika Gupta and Anirban Basu
    Citation: Journal of Neuroinflammation 2012 9:57
  11. Schizophrenia is a debilitating and complex mental disorder whose exact etiology remains unknown. There is growing amount of evidence of a relationship between neuroinflammation, as demonstrated by microglial ...

    Authors: Kristian Liaury, Tsuyoshi Miyaoka, Toshiko Tsumori, Motohide Furuya, Rei Wake, Masa Ieda, Keiko Tsuchie, Michiyo Taki, Kotomi Ishihara, Andi Jayalangkara Tanra and Jun Horiguchi
    Citation: Journal of Neuroinflammation 2012 9:56
  12. Microglia are one of the main cell types to be productively infected by HIV-1 in the central nervous system (CNS). Leukotriene B4 (LTB4) and cysteinyl-leukotrienes such as LTC4 are some of the proinflammatory mol...

    Authors: Jonathan Bertin, Corinne Barat, Dave Bélanger and Michel J Tremblay
    Citation: Journal of Neuroinflammation 2012 9:55
  13. S100B is a calcium-binding protein that is produced primarily by astrocytes. Increased serum S100B protein levels reflect neurological damage. Autoimmunity may have a role in the pathogenesis of autism in some...

    Authors: Laila Yousef Al-Ayadhi and Gehan Ahmed Mostafa
    Citation: Journal of Neuroinflammation 2012 9:54
  14. Chondroitin sulfate proteoglycans are major inhibitory molecules for neural plasticity under both physiological and pathological conditions. The chondroitin sulfate degrading enzyme chondroitinase ABC promotes...

    Authors: Ryoji Tauchi, Shiro Imagama, Takamitsu Natori, Tomohiro Ohgomori, Akio Muramoto, Ryuichi Shinjo, Yukihiro Matsuyama, Naoki Ishiguro and Kenji Kadomatsu
    Citation: Journal of Neuroinflammation 2012 9:53
  15. Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated. In ...

    Authors: Ankit Shah, Peter S Silverstein, Dhirendra P Singh and Anil Kumar
    Citation: Journal of Neuroinflammation 2012 9:52
  16. Long-term acetate supplementation reduces neuroglial activation and cholinergic cell loss in a rat model of lipopolysaccharide-induced neuroinflammation. Additionally, a single dose of glyceryl triacetate, use...

    Authors: Mahmoud L Soliman, Mark D Smith, Heidi M Houdek and Thad A Rosenberger
    Citation: Journal of Neuroinflammation 2012 9:51
  17. Neuropathology caused by acute viral infection of the brain is associated with the development of persistent neurological deficits. Identification of the immune effectors responsible for injuring the brain dur...

    Authors: Charles L Howe, Reghann G LaFrance-Corey, Rhianna S Sundsbak and Stephanie J LaFrance
    Citation: Journal of Neuroinflammation 2012 9:50
  18. In addition to cytotoxic mechanisms directly impacting neurons, β-amyloid (Aβ)-induced glial activation also promotes release of proinflammatory molecules that may self-perpetuate reactive gliosis and damage n...

    Authors: Caterina Scuderi, Marta Valenza, Claudia Stecca, Giuseppe Esposito, Maria Rosaria Carratù and Luca Steardo
    Citation: Journal of Neuroinflammation 2012 9:49
  19. An increase in intracellular calcium concentration [Ca2+]i is one of the first events to take place after brain ischemia. A key [Ca2+]i-regulated signaling molecule is the phosphatase calcineurin (CN), which play...

    Authors: Mónica Sobrado, Belén G Ramirez, Fernando Neria, Ignacio Lizasoain, Maria Lourdes Arbones, Takashi Minami, Juan Miguel Redondo, María Ángeles Moro and Eva Cano
    Citation: Journal of Neuroinflammation 2012 9:48
  20. Neurodegeneration, induced by misfolded tau protein, and neuroinflammation, driven by glial cells, represent the salient features of Alzheimer's disease (AD) and related human tauopathies. While tau neurodegen...

    Authors: Norbert Zilka, Zuzana Kazmerova, Santosh Jadhav, Peter Neradil, Aladar Madari, Dominika Obetkova, Ondrej Bugos and Michal Novak
    Citation: Journal of Neuroinflammation 2012 9:47
  21. Inflammatory injury plays a critical role in intracerebral hemorrhage (ICH)-induced neurological deficits; however, the signaling pathways are not apparent by which the upstream cellular events trigger innate ...

    Authors: Sen Lin, Qing Yin, Qi Zhong, Feng-Lin Lv, Yu Zhou, Jing-Qi Li, Jing-Zhou Wang, Bing-yin Su and Qing-Wu Yang
    Citation: Journal of Neuroinflammation 2012 9:46
  22. Cerebral cortical neurons have a high vulnerability to the harmful effects of hypoxia. However, the brain has the ability to detect and accommodate to hypoxic conditions. This phenomenon, known as precondition...

    Authors: Ramiro Echeverry, Fang Wu, Woldeab B Haile, Jialing Wu and Manuel Yepes
    Citation: Journal of Neuroinflammation 2012 9:45
  23. Cerebral inflammation is a hallmark of neuronal degeneration. Dipeptidyl peptidase IV, aminopeptidase N as well as the dipeptidyl peptidases II, 8 and 9 and cytosolic alanyl-aminopeptidase are involved in the ...

    Authors: Peter Röhnert, Werner Schmidt, Patrick Emmerlich, Alexander Goihl, Sabine Wrenger, Ute Bank, Karsten Nordhoff, Michael Täger, Siegfried Ansorge, Dirk Reinhold and Frank Striggow
    Citation: Journal of Neuroinflammation 2012 9:44
  24. Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in associ...

    Authors: Kimberly R Byrnes, David J Loane, Bogdan A Stoica, Jiangyang Zhang and Alan I Faden
    Citation: Journal of Neuroinflammation 2012 9:43
  25. Transforming growth factor β (TGF-β) is a cytokine having multiple functions in the central nervous system such as promoting repair mechanisms in degenerative diseases and stroke. To date, however, its neuropr...

    Authors: Fabrizio Piras, Francesca Salani, Paola Bossù, Carlo Caltagirone and Gianfranco Spalletta
    Citation: Journal of Neuroinflammation 2012 9:42
  26. CD4+ CD25+ forkhead box P3 (FoxP3)+ regulatory T cells (T reg cells) are known to suppress adaptive immune responses, key control tolerance and autoimmunity.

    Authors: Kerstin Göbel, Stefan Bittner, Nico Melzer, Susann Pankratz, Angela Dreykluft, Michael K Schuhmann, Sven G Meuth and Heinz Wiendl
    Citation: Journal of Neuroinflammation 2012 9:41
  27. Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have shown that different pathways of macrophage activation result in cells with different properties. Interleukin (IL)-6 triggers the clas...

    Authors: Alexander Rodriguez Guerrero, Kenzo Uchida, Hideaki Nakajima, Shuji Watanabe, Masaya Nakamura, William EB Johnson and Hisatoshi Baba
    Citation: Journal of Neuroinflammation 2012 9:40
  28. TIR-domain-containing adapter-inducing interferon-β (TRIF) is the sole downstream adaptor of Toll-like receptor (TLR)3, which is one of the major signaling pathways in immune cells leading to neuroinflammation...

    Authors: Sen Lin, Yajie Liang, Jiqiang Zhang, Chen Bian, Hongli Zhou, Qiang Guo, Ying Xiong, Shurong Li and Bingyin Su
    Citation: Journal of Neuroinflammation 2012 9:39
  29. Several recent studies have shown that angiotensin type 1 receptor (AT1) antagonists such as candesartan inhibit the microglial inflammatory response and dopaminergic cell loss in animal models of Parkinson's ...

    Authors: Pablo Garrido-Gil, Belen Joglar, Ana I Rodriguez-Perez, Maria J Guerra and Jose L Labandeira-Garcia
    Citation: Journal of Neuroinflammation 2012 9:38
  30. In invertebrates, the medicinal leech is considered to be an interesting and appropriate model to study neuroimmune mechanisms. Indeed, this non-vertebrate animal can restore normal function of its central ner...

    Authors: Muriel Tahtouh, Annelise Garçon-Bocquet, Françoise Croq, Jacopo Vizioli, Pierre-Eric Sautière, Christelle Van Camp, Michel Salzet, Patricia Nagnan-le Meillour, Joël Pestel and Christophe Lefebvre
    Citation: Journal of Neuroinflammation 2012 9:37
  31. Sustained neuroinflammation strongly contributes to the pathogenesis of pain. The clinical challenge of chronic pain relief led to the identification of molecules such as cytokines, chemokines and more recentl...

    Authors: Lara Kular, Cyril Rivat, Brigitte Lelongt, Claire Calmel, Maryvonne Laurent, Michel Pohl, Patrick Kitabgi, Stéphane Melik-Parsadaniantz and Cécile Martinerie
    Citation: Journal of Neuroinflammation 2012 9:36
  32. Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In t...

    Authors: Young-Jung Lee, Dong-Young Choi, Im Seop Choi, Ki Ho Kim, Young Hee Kim, Hwan Mook Kim, Kiho Lee, Won Gil Cho, Jea Kyung Jung, Sang Bae Han, Jin-Yi Han, Sang-Yoon Nam, Young Won Yun, Jae Hwang Jeong, Ki-Wan Oh and Jin Tae Hong
    Citation: Journal of Neuroinflammation 2012 9:35
  33. The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; howe...

    Authors: Jee Hoon Lee, Hyunmi Kim, Joo Hong Woo, Eun-hye Joe and Ilo Jou
    Citation: Journal of Neuroinflammation 2012 9:34
  34. A brief exposure to systemic hypoxia (i.e., hypoxic preconditioning; HPC) prior to transient middle cerebral artery occlusion (tMCAo) reduces infarct volume, blood-brain barrier disruption, and leukocyte migra...

    Authors: Ann M Stowe, Bradley K Wacker, Petra D Cravens, Jennifer L Perfater, Min K Li, Ruilong Hu, Angela B Freie, Olaf Stüve and Jeffrey M Gidday
    Citation: Journal of Neuroinflammation 2012 9:33
  35. Both (-) and (+)-naloxone attenuate inflammation-mediated neurodegeneration by inhibition of microglial activation through superoxide reduction in an opioid receptor-independent manner. Multiple lines of evide...

    Authors: Qingshan Wang, Hui Zhou, Huiming Gao, Shih-Heng Chen, Chun-Hsien Chu, Belinda Wilson and Jau-Shyong Hong
    Citation: Journal of Neuroinflammation 2012 9:32
  36. Traumatic brain injury (TBI) induces activation of microglia. Activated microglia can in turn increase secondary injury and impair recovery. This innate immune response requires hours to days to become fully m...

    Authors: Joana C d’Avila, Tina I Lam, Deborah Bingham, Jian Shi, Seok Joon Won, Tiina M Kauppinen, Stephen Massa, Jialing Liu and Raymond A Swanson
    Citation: Journal of Neuroinflammation 2012 9:31
  37. In humans, inflammation of either the urinary bladder or the distal colon often results in sensory cross-sensitization between these organs. Limited information is known about the mechanisms underlying this cl...

    Authors: Chun-Mei Xia, Melisa A Gulick, Sharon J Yu, John R Grider, Karnam S Murthy, John F Kuemmerle, Hamid I Akbarali and Li-Ya Qiao
    Citation: Journal of Neuroinflammation 2012 9:30
  38. Multiple sclerosis (MS) is associated with pathogenic autoimmunity primarily focused on major CNS-myelin target antigens including myelin basic protein (MBP), proteolipidprotein (PLP), myelin oligodendrocyte p...

    Authors: Nathali Kaushansky, Daniel M Altmann, Chella S David, Hans Lassmann and Avraham Ben-Nun
    Citation: Journal of Neuroinflammation 2012 9:29
  39. To functionally characterize pro-inflammatory and vasoconstrictive properties of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage (SAH) in vivo and in vitro.

    Authors: Ulf C Schneider, Jennifer Schiffler, Nahid Hakiy, Peter Horn and Peter Vajkoczy
    Citation: Journal of Neuroinflammation 2012 9:28
  40. Most of the known functions of microglia, including neurotoxic and neuroprotective properties, are attributed to morphologically-activated microglia. Resting, ramified microglia are suggested to primarily moni...

    Authors: Jonathan Vinet, Hilmar RJ van Weering, Annette Heinrich, Roland E Kälin, Anja Wegner, Nieske Brouwer, Frank L Heppner, Nico van Rooijen, Hendrikus WGM Boddeke and Knut Biber
    Citation: Journal of Neuroinflammation 2012 9:27
  41. Platelet-derived growth factor D (PDGF-D) plays an important role in angiogenesis, vessel remodeling, inflammation and repair in response to injury. We hypothesized that genetic variation in PDGFD gene might alte...

    Authors: Yongyi Bai, Jingzhou Chen, Kai Sun, Yibo Wang and Rutai Hui
    Citation: Journal of Neuroinflammation 2012 9:26
  42. The cellular prion protein (PrPc) is a host-encoded glycoprotein whose transconformation into PrP scrapie (PrPSc) initiates prion diseases. The role of PrPc in health is still obscure, but many candidate funct...

    Authors: Pauline Gourdain, Clara Ballerini, Arnaud B Nicot and Claude Carnaud
    Citation: Journal of Neuroinflammation 2012 9:25
  43. We have previously reported that electroacupuncture (EA) pretreatment induced tolerance against cerebral ischemic injury, but the mechanisms underlying this effect of EA are unknown. In this study, we assessed...

    Authors: Qiang Wang, Feng Wang, Xin Li, Qianzi Yang, Xuying Li, Ning Xu, Yi Huang, Qiaomei Zhang, Xingchun Gou, Shaoyang Chen and Lize Xiong
    Citation: Journal of Neuroinflammation 2012 9:24
  44. Chronic neuroinflammation is a hallmark of several neurological disorders associated with cognitive loss. Activated microglia and secreted factors such as tumor necrosis factor (TNF)-α are key mediators of neu...

    Authors: Karim Belarbi, Timothy Jopson, David Tweedie, Carla Arellano, Weiming Luo, Nigel H Greig and Susanna Rosi
    Citation: Journal of Neuroinflammation 2012 9:23
  45. Microglia, the resident immune cells of the brain, have been implicated in brain injury and various neurological disorders. However, their precise roles in different pathophysiological situations remain enigma...

    Authors: S Sakura Minami, Binggui Sun, Ketul Popat, Tiina Kauppinen, Mike Pleiss, Yungui Zhou, Michael E Ward, Paul Floreancig, Lennart Mucke, Tejal Desai and Li Gan
    Citation: Journal of Neuroinflammation 2012 9:22
  46. Interleukin 6 (IL-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in Alzheimer's disease (AD) brain. However, previous studies relating IL-6 genetic polymorphisms to ...

    Authors: Shih-Yuan Chen, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, Yu Sun, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu and Yen-Ching Chen
    Citation: Journal of Neuroinflammation 2012 9:21
  47. The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological fe...

    Authors: Grace Li, Margaret M Esiri, Olaf Ansorge and Gabriele C DeLuca
    Citation: Journal of Neuroinflammation 2012 9:20
  48. Correction to Rao J S, Kim H W, Kellom M, Greenstein D, Chen M, Kraft A D, Harry G J, Rapoport S I, Basselin M. Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, ...

    Authors: Jagadeesh Sridhara Rao, Hyung-Wook Kim, Matthew Kellom, Dede Greenstein, Mei Chen, Andrew David Kraft, Gaylia Jean Harry, Stanley Isaac Rapoport and Mireille Basselin
    Citation: Journal of Neuroinflammation 2012 9:19

    The original article was published in Journal of Neuroinflammation 2011 8:101

  49. Brain edema as a result of secondary injury following traumatic brain injury (TBI) is a major clinical concern. Neutrophils are known to cause increased vascular permeability leading to edema formation in peri...

    Authors: Ellinor Kenne, Anna Erlandsson, Lennart Lindbom, Lars Hillered and Fredrik Clausen
    Citation: Journal of Neuroinflammation 2012 9:17

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