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  1. Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate and breast carcinomas have been implicated in the progression toward cancer malignant phenotype. Only partial data are availabl...

    Authors: Marco Tafani, Maura Di Vito, Alessandro Frati, Laura Pellegrini, Elena De Santis, Giovanni Sette, Adriana Eramo, Patrizio Sale, Emanuela Mari, Antonio Santoro, Antonino Raco, Maurizio Salvati, Ruggero De Maria and Matteo A Russo
    Citation: Journal of Neuroinflammation 2011 8:32
  2. Permanent functional deficits following spinal cord injury (SCI) arise both from mechanical injury and from secondary tissue reactions involving inflammation. Enhanced release of adenosine and glutamate soon a...

    Authors: Irene Paterniti, Alessia Melani, Sara Cipriani, Francesca Corti, Tommaso Mello, Emanuela Mazzon, Emanuela Esposito, Placido Bramanti, Salvatore Cuzzocrea and Felicita Pedata
    Citation: Journal of Neuroinflammation 2011 8:31
  3. Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, I...

    Authors: Juen-Haur Hwang, Jin-Cherng Chen, Shan-Ying Yang, Ming-Fu Wang and Yin-Ching Chan
    Citation: Journal of Neuroinflammation 2011 8:30
  4. Status epilepticus (SE) is proposed to lead to an age-dependent acute activation of a repertoire of inflammatory processes, which may contribute to neuronal damage in the hippocampus. The extent and temporal p...

    Authors: Juha T Järvelä, Francisco R Lopez-Picon, Anna Plysjuk, Saku Ruohonen and Irma E Holopainen
    Citation: Journal of Neuroinflammation 2011 8:29
  5. Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, is capable of activating the small GTPase RhoA, which in turn contributes to endothelial barrier dysfunction. However, the underlying signaling mechani...

    Authors: Jing Peng, Fang He, Ciliu Zhang, Xiaolu Deng and Fei Yin
    Citation: Journal of Neuroinflammation 2011 8:28
  6. Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activa...

    Authors: Anthony Lyons, Kevin J Murphy, Rachael Clarke and Marina A Lynch
    Citation: Journal of Neuroinflammation 2011 8:27
  7. Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops. The rapid removal of degenerated myelin by phag...

    Authors: Miri Gitik, Sigal Liraz-Zaltsman, Per-Arne Oldenborg, Fanny Reichert and Shlomo Rotshenker
    Citation: Journal of Neuroinflammation 2011 8:24
  8. Dengue, one of the most important arboviral diseases of humans, may cause severe systemic disease. Although dengue virus (DENV) has been considered to be a non-neurotropic virus, dengue infection has been asso...

    Authors: Debora CG Amaral, Milene A Rachid, Marcia C Vilela, Roberta DL Campos, Gustavo P Ferreira, David H Rodrigues, Norinne Lacerda-Queiroz, Aline S Miranda, Vivian V Costa, Marco A Campos, Erna G Kroon, Mauro M Teixeira and Antonio L Teixeira
    Citation: Journal of Neuroinflammation 2011 8:23
  9. Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the e...

    Authors: Maria J Bellini, Claudia B Hereñú, Rodolfo G Goya and Luis M Garcia-Segura
    Citation: Journal of Neuroinflammation 2011 8:21
  10. Dorsal root reflexes (DRRs) are antidromic activities traveling along the primary afferent fibers, which can be generated by peripheral stimulation or central stimulation. DRRs are thought to be involved in th...

    Authors: Oleg V Lobanov and Yuan B Peng
    Citation: Journal of Neuroinflammation 2011 8:20
  11. Non-neuronal cells, such as microglia and lymphocytes, are thought to be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Previous studies have demonstrated neuroprotective effects of lymph...

    Authors: Satoru Tada, Tatsusada Okuno, Teruhito Yasui, Yuji Nakatsuji, Tomoyuki Sugimoto, Hitoshi Kikutani and Saburo Sakoda
    Citation: Journal of Neuroinflammation 2011 8:19
  12. Activation of indoleamine 2,3-dioxygenase (IDO) and higher concentrations of several kynurenine metabolites have been observed post-stroke, where they have been associated with increased mortality. While lower...

    Authors: Allison B Gold, Nathan Herrmann, Walter Swardfager, Sandra E Black, Richard I Aviv, Gayla Tennen, Alexander Kiss and Krista L Lanctôt
    Citation: Journal of Neuroinflammation 2011 8:17
  13. Stromal cell-derived factor-1 (SDF1) and its major signaling receptor, CXCR4, were initially described in the immune system; however, they are also expressed in the nervous system, including the spinal cord. A...

    Authors: Vicki M Tysseling, Divakar Mithal, Vibhu Sahni, Derin Birch, Hosung Jung, Richard J Miller and John A Kessler
    Citation: Journal of Neuroinflammation 2011 8:16

    The Erratum to this article has been published in Journal of Neuroinflammation 2017 14:35

  14. Lipopolysaccharide (LPS), the major component of the outer membrane of gram-negative bacteria, can activate immune cells including macrophages. Activation of macrophages in the central nervous system (CNS) con...

    Authors: Jieliang Li, Li Ye, Denise R Cook, Xu Wang, Jinping Liu, Dennis L Kolson, Yuri Persidsky and Wen-Zhe Ho
    Citation: Journal of Neuroinflammation 2011 8:15
  15. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that contributes to neuronal injury in various degenerative diseases, and is therefore a potential therapeutic target. It exerts its biological effect by a...

    Authors: Fabrizio Gardoni, Mariaserena Boraso, Elisa Zianni, Emanuela Corsini, Corrado L Galli, Flaminio Cattabeni, Marina Marinovich, Monica Di Luca and Barbara Viviani
    Citation: Journal of Neuroinflammation 2011 8:14
  16. Sphingosine kinase 1 (SphK1), a key enzyme responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P) has been shown to be expressed in monocytes and monocyte-derived peripheral macrophages...

    Authors: Haiyan Lin, Nimmi Baby, Jia Lu, Charanjit Kaur, Chuansen Zhang, Jiajun Xu, Eng-Ang Ling and S Thameem Dheen
    Citation: Journal of Neuroinflammation 2011 8:13
  17. Exogenous administration of insulin-like growth factor (IGF)-I has anti-depressant properties in rodent models of depression. However, nothing is known about the anti-depressant properties of IGF-I during infl...

    Authors: Sook-Eun Park, Robert Dantzer, Keith W Kelley and Robert H McCusker
    Citation: Journal of Neuroinflammation 2011 8:12
  18. Recent studies have suggested that the scavenger receptor MARCO (macrophage receptor with collagenous structure) mediates activation of the immune response in bacterial infection of the central nervous system ...

    Authors: Benedikt J Braun, Alexander Slowik, Stephen L Leib, Ralph Lucius, Deike Varoga, Christoph J Wruck, Sandra Jansen, Rainer Podschun, Thomas Pufe and Lars-Ove Brandenburg
    Citation: Journal of Neuroinflammation 2011 8:11
  19. The neuropeptide substance-P (SP) is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic inflammation. The promoter of TAC1 (TAC1prom) plays a central role in the re...

    Authors: Lynne Shanley, Marissa Lear, Scott Davidson, Ruth Ross and Alasdair MacKenzie
    Citation: Journal of Neuroinflammation 2011 8:10
  20. Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. The cause of the neurodegeneration is unknown. Neuroinflammation has been clearly shown in Parkinson'...

    Authors: Mibel M Pabon, Adam D Bachstetter, Charles E Hudson, Carmelina Gemma and Paula C Bickford
    Citation: Journal of Neuroinflammation 2011 8:9
  21. Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induce...

    Authors: Makoto Horiuchi, Aki Itoh, David Pleasure, Keiko Ozato and Takayuki Itoh
    Citation: Journal of Neuroinflammation 2011 8:8
  22. Hearing loss is a frequent long-term complication of pneumococcal meningitis (PM). Its main pathological correlate is damage to the organ of Corti and loss of spiral ganglion neurons. The only current treatmen...

    Authors: Cornelia Demel, Tobias Hoegen, Armin Giese, Barbara Angele, Hans-Walter Pfister, Uwe Koedel and Matthias Klein
    Citation: Journal of Neuroinflammation 2011 8:7
  23. We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlyin...

    Authors: Xiao-Peng Mei, Hui Zhang, Wei Wang, Yan-Yan Wei, Ming-Zhu Zhai, Wen Wang, Li-Xian Xu and Yun-Qing Li
    Citation: Journal of Neuroinflammation 2011 8:6
  24. The phytocannabinoid cannabidiol (CBD) exhibits antioxidant and antiinflammatory properties. The present study was designed to explore its effects in a mouse model of sepsis-related encephalitis by intravenous...

    Authors: Lourdes Ruiz-Valdepeñas, José A Martínez-Orgado, Cristina Benito, África Millán, Rosa M Tolón and Julián Romero
    Citation: Journal of Neuroinflammation 2011 8:5
  25. Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine mo...

    Authors: Maria I Fonseca, Shu-Hui Chu, Alisia M Berci, Marie E Benoit, Douglas G Peters, Yuko Kimura and Andrea J Tenner
    Citation: Journal of Neuroinflammation 2011 8:4
  26. β-Amyloid peptide (Aβ) is a major protein in the brain associated with Alzheimer's and Parkinson's diseases. The purpose of this study was to investigate the role of macrophage antigen-1 (MAC1) receptor, an in...

    Authors: Dan Zhang, Xiaoming Hu, Li Qian, Shih-Heng Chen, Hui Zhou, Belinda Wilson, David S Miller and Jau-Shyong Hong
    Citation: Journal of Neuroinflammation 2011 8:3
  27. The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are inv...

    Authors: Ana Leda F Longhini, Felipe von Glehn, Carlos Otávio Brandão, Rosemeire FO de Paula, Fernando Pradella, Adriel S Moraes, Alessandro S Farias, Elaine C Oliveira, Juan G Quispe-Cabanillas, Cassiana Horta Abreu, Alfredo Damasceno, Benito P Damasceno, Konstantin E Balashov and Leonilda MB Santos
    Citation: Journal of Neuroinflammation 2011 8:2
  28. Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High amounts of NO are synthesized following up-regulatio...

    Authors: Lucia Lisi, Pierluigi Navarra, Douglas L Feinstein and Cinzia Dello Russo
    Citation: Journal of Neuroinflammation 2011 8:1
  29. Deciphering the mechanisms that modulate the inflammatory response induced by microglial activation not only improves our insight into neuroinflammation but also provides avenues for designing novel therapies ...

    Authors: Mei-Jen Wang, Hsin-Yi Huang, Wu-Fu Chen, Hui-Fen Chang and Jon-Son Kuo
    Citation: Journal of Neuroinflammation 2010 7:99
  30. Kinin B1 receptors are inducible molecules up-regulated after inflammatory stimuli. This study evaluated the relevance of kinin B1 receptors in a mouse depression behavior model.

    Authors: Alice F Viana, Izaque S Maciel, Fabiana N Dornelles, Claudia P Figueiredo, Jarbas M Siqueira, Maria M Campos and João B Calixto
    Citation: Journal of Neuroinflammation 2010 7:98
  31. The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine expressions have be...

    Authors: Ankit Shah and Anil Kumar
    Citation: Journal of Neuroinflammation 2010 7:96
  32. Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in multiple sclerosis (MS) is unclear. Central nervous system lesions from both MS and experimental autoimmune encephalomyel...

    Authors: Timothy J Seabrook, Amanda Littlewood-Evans, Volker Brinkmann, Bernadette Pöllinger, Christian Schnell and Peter C Hiestand
    Citation: Journal of Neuroinflammation 2010 7:95
  33. Inflammation acting in synergy with brain ischemia aggravates perinatal ischemic brain damage. The sensitizing effect of pro-inflammatory exposure prior to hypoxia is dependent on signaling by TNF-α through TN...

    Authors: Tina Markus, Stefan R Hansson, Tobias Cronberg, Corrado Cilio, Tadeusz Wieloch and David Ley
    Citation: Journal of Neuroinflammation 2010 7:94
  34. Interactions between fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated impairments in CX3CL1 and CX3CR1 are directly as...

    Authors: Angela W Corona, Yan Huang, Jason C O'Connor, Robert Dantzer, Keith W Kelley, Phillip G Popovich and Jonathan P Godbout
    Citation: Journal of Neuroinflammation 2010 7:93
  35. Unilateral vestibular deafferentation results in strong microglial and astroglial activation in the vestibular nuclei (VN) that could be due to an inflammatory response. This study was aimed at determining if ...

    Authors: Martine Liberge, Christine Manrique, Laurence Bernard-Demanze and Michel Lacour
    Citation: Journal of Neuroinflammation 2010 7:91
  36. Purified intravenous immunoglobulin (IVIG) obtained from the plasma of healthy humans is indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. IVIG cont...

    Authors: Johanna Magga, Lakshman Puli, Rea Pihlaja, Katja Kanninen, Suvi Neulamaa, Tarja Malm, Wolfgang Härtig, Jens Grosche, Gundars Goldsteins, Heikki Tanila, Jari Koistinaho and Milla Koistinaho
    Citation: Journal of Neuroinflammation 2010 7:90
  37. Studies of cerebral ischemia and other neuroinflammatory states have demonstrated a strong association between new vessel formation and microglial recruitment and activation, raising the possibility that micro...

    Authors: Jennifer V Welser, Longxuan Li and Richard Milner
    Citation: Journal of Neuroinflammation 2010 7:89
  38. Transforming growth factor-β (TGF-β) and matrix metalloproteinases (MMPs) are the multifunctional factors during diverse physiological and pathological processes including development, wound healing, prolifera...

    Authors: Hsi-Lung Hsieh, Hui-Hsin Wang, Wen-Bin Wu, Po-Ju Chu and Chuen-Mao Yang
    Citation: Journal of Neuroinflammation 2010 7:88
  39. The causes of age-related macular degeneration (AMD) are not well understood. Due to demographic shifts in the industrialized world a growing number of people will develop AMD in the coming decades. To develop...

    Authors: William Raoul, Constance Auvynet, Serge Camelo, Xavier Guillonneau, Charles Feumi, Christophe Combadière and Florian Sennlaub
    Citation: Journal of Neuroinflammation 2010 7:87
  40. Prostaglandin E2 (PGE2), an arachidonic acid metabolite converted by cyclooxygenase-2 (COX-2), plays important roles in the regulation of endothelial functions in response to bacterial infection. The enzymatic ac...

    Authors: Ruey-Horng Shih and Chuen-Mao Yang
    Citation: Journal of Neuroinflammation 2010 7:86
  41. Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral b...

    Authors: Hyun-Ja Jeong, In-Young Choi, Min-Ho Kim, Hyung-Min Kim, Phil-Dong Moon, Jin-Woo Hong and Soo-Hyun Kim
    Citation: Journal of Neuroinflammation 2010 7:85
  42. Lipoteichoic acid (LTA) is a component of Gram-positive bacterial cell walls, which has been found to be elevated in cerebrospinal fluid of patients suffering from meningitis. Moreover, matrix metalloproteinas...

    Authors: Hui-Hsin Wang, Hsi-Lung Hsieh and Chuen-Mao Yang
    Citation: Journal of Neuroinflammation 2010 7:84
  43. Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, n...

    Authors: Francesca L'Episcopo, Cataldo Tirolo, Salvatore Caniglia, Nunzio Testa, Pier A Serra, Francesco Impagnatiello, Maria C Morale and Bianca Marchetti
    Citation: Journal of Neuroinflammation 2010 7:83
  44. Methamphetamine (MA) use is associated with activation of microglia and, at high doses, can induce neurotoxicity. Given the changes in the neuroinflammatory environment associated with MA, we investigated whet...

    Authors: Jessica B Buchanan, Nathan L Sparkman and Rodney W Johnson
    Citation: Journal of Neuroinflammation 2010 7:82

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