Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011;364:255–64.
Article
PubMed
PubMed Central
CAS
Google Scholar
Rees CM, Pierro A, Eaton S. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Arch Dis Child Fetal Neonatal Ed. 2007;92:F193–8.
Article
PubMed
Google Scholar
van Vliet EO, de Kieviet JF, Oosterlaan J, van Elburg RM. Perinatal infections and neurodevelopmental outcome in very preterm and very low-birth-weight infants: a meta-analysis. JAMA Pediatr. 2013;167:662-8.
Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, et al. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005;115:696–703.
Article
PubMed
Google Scholar
Merhar SL, Ramos Y, Meinzen-Derr J, Kline-Fath BM. Brain magnetic resonance imaging in infants with surgical necrotizing enterocolitis or spontaneous intestinal perforation versus medical necrotizing enterocolitis. J Pediatr. 2014;164:410.
Article
PubMed
Google Scholar
Roze E, Ta BDP, van der Ree MH, Tanis JC, van Braeckel KNJA, Hulscher JBF, et al. Functional impairments at school age of children with necrotizing enterocolitis or spontaneous intestinal perforation. Pediatr Res. 2011;70:619–25.
Article
PubMed
Google Scholar
Strunk T, Inder T, Wang XY, Burgner D, Mallard C, Levy O. Infection-induced inflammation and cerebral injury in preterm infants. Lancet Infect Dis. 2014;14:751–62.
Gussenhoven R, Westerlaken RJJ, Ophelders D, Jobe AH, Kemp MW, Kallapur SG, et al. Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. J Neuroinflammation. 2018;15:113.
Article
PubMed
PubMed Central
Google Scholar
Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci. 2005;25:8000–9.
Article
PubMed
CAS
Google Scholar
Wang K-C, Fan L-W, Kaizaki A, Pang Y, Cai Z, Tien L-T. Neonatal lipopolysaccharide exposure induces long-lasting learning impairment, less anxiety-like response and hippocampal injury in adult rats. Neuroscience. 2013;234:146–57.
Article
PubMed
PubMed Central
CAS
Google Scholar
Smith PLP, Hagberg H, Naylor AS, Mallard C. Neonatal peripheral immune challenge activates microglia and inhibits neurogenesis in the developing murine hippocampus. Dev Neurosci. 2014;36:119–31.
Article
PubMed
CAS
Google Scholar
Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, et al. Chronic intestinal inflammation alters hippocampal neurogenesis. J Neuroinflammation. 2015;12:65.
Article
PubMed
PubMed Central
CAS
Google Scholar
Elmore MRP, Burton MD, Conrad MS, Rytych JL, Van Alstine WG, Johnson RW. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. J Neurosci. 2014;34:2120–9.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bilbo SD, Schwarz JM. The immune system and developmental programming of brain and behavior. Front Neuroendocrinol. 2012;33:267–86.
Article
PubMed
PubMed Central
CAS
Google Scholar
Williamson LL, Sholar PW, Mistry RS, Smith SH, Bilbo SD. Microglia and memory: modulation by early-life infection. J Neurosci. 2011;31:15511–21.
Article
PubMed
PubMed Central
CAS
Google Scholar
Donzis EJ, Tronson NC. Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences. Neurobiol Learn Mem. 2014;115:68–77.
Article
PubMed
CAS
Google Scholar
Crampton SJ, O'Keeffe GW. NF-kappaB: emerging roles in hippocampal development and function. Int J Biochem Cell Biol. 2013;45:1821–4.
Article
PubMed
CAS
Google Scholar
Naureen I, Waheed KAI, Rathore AW, Victor S, Mallucci C, Goodden JR, et al. Fingerprint changes in CSF composition associated with different aetiologies in human neonatal hydrocephalus: inflammatory cytokines. Childs Nerv Syst. 2014;30:1155–64.
Article
PubMed
Google Scholar
Ellison VJ, Mocatta TJ, Winterbourn CC, Darlow BA, Volpe JJ, Inder TE. The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn. Pediatr Res. 2005;57:282–6.
Article
PubMed
CAS
Google Scholar
Hall NJ, Hiorns M, Tighe H, Peters M, Khoo AK, Eaton S, et al. Is necrotizing enterocolitis associated with development or progression of intraventricular hemorrhage? Am J Perinatol. 2009;26:139–43.
Article
PubMed
Google Scholar
Sangild PT, Thymann T, Schmidt M, Stoll B, Burrin DG, Buddington RK. Invited review: the preterm pig as a model in pediatric gastroenterology. J Anim Sci. 2013;91:4713–29.
Article
PubMed
PubMed Central
CAS
Google Scholar
Nguyen DN, Jiang P, Frokiaer H, Heegaard PM, Thymann T, Sangild PT. Delayed development of systemic immunity in preterm pigs as a model for preterm infants. Sci Rep. 2016;6:36816.
Article
PubMed
PubMed Central
CAS
Google Scholar
Andersen AD, Sangild PT, Munch SL, van der Beek EM, Renes IB, Ginneken C, et al. Delayed growth, motor function and learning in preterm pigs during early postnatal life. Am J Physiol Regul Integr Comp Physiol. 2016;310:R481–R92.
Article
PubMed
Google Scholar
Sun J, Li Y, Nguyen DN, Mortensen MS, van den Akker CHP, Skeath T, et al. Nutrient fortification of human donor milk affects intestinal function and protein metabolism in preterm pigs. J Nutr. 2018;148:336–47.
Article
PubMed
Google Scholar
Li Y, Nguyen DN, de Waard M, Christensen L, Zhou P, Jiang P, et al. Pasteurization procedures for donor human milk affect body growth, intestinal structure, and resistance against bacterial infections in preterm pigs. J Nutr. 2017;147:1121–30.
Article
PubMed
CAS
Google Scholar
Cao MQ, Andersen AD, Van Ginneken C, Shen RL, Petersen SO, Thymann T, et al. Physical activity level is impaired and diet dependent in preterm newborn pigs. Pediatr Res. 2015;78:137–44.
Article
PubMed
Google Scholar
Zhang Y, Ortega G, Camp M, Osen H, Chang DC, Abdullah F. Necrotizing enterocolitis requiring surgery: outcomes by intestinal location of disease in 4371 infants. J Pediatr Surg. 2011;46:1475–81.
Article
PubMed
Google Scholar
Stoy ACF, Heegaard PMH, Skovgaard K, Bering SB, Bjerre M, Sangild PT. Increased intestinal inflammation and digestive dysfunction in preterm pigs with severe necrotizing enterocolitis. Neonatology. 2017;111:289–96.
Article
PubMed
CAS
Google Scholar
Kirschner MB, Kao SC, Edelman JJ, Armstrong NJ, Vallely MP, van Zandwijk N, et al. Haemolysis during sample preparation alters microRNA content of plasma. PLoS One. 2011;6:e24145.
Article
PubMed
PubMed Central
CAS
Google Scholar
Moldovan M, Pinchenko V, Dmytriyeva O, Pankratova S, Fugleholm K, Klingelhofer J, et al. Peptide mimetic of the S100A4 protein modulates peripheral nerve regeneration and attenuates the progression of neuropathy in myelinprotein P(0) null mice. Mol Med. 2013;19:43–53.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sveinsdottir S, Gram M, Cinthio M, Sveinsdottir K, Morgelin M, Ley D. Altered expression of aquaporin 1 and 5 in the choroid plexus following preterm intraventricular hemorrhage. Dev Neurosci. 2014;36:542–51.
Article
PubMed
CAS
Google Scholar
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc. 2012;7:562–78.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, et al. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics. 2009;25:1091–3.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bergström A, Kaalund SS, Skovgaard K, Andersen AD, Pakkenberg B, Rosenørn A, et al. Limited effects of preterm birth and the first enteral nutrition on cerebellum morphology and gene expression in piglets. Physiol Rep. 2016;4:e12871.
Article
PubMed
PubMed Central
CAS
Google Scholar
Vinther AM, Heegaard PM, Skovgaard K, Buhl R, Andreassen SM, Andersen PH. Characterization and differentiation of equine experimental local and early systemic inflammation by expression responses of inflammation-related genes in peripheral blood leukocytes. BMC Vet Res. 2016;12:83.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gundersen HJG, Jensen EBV, Kieu K, Nielsen J. The efficiency of systematic sampling in stereology-reconsidered. J Microsc. 1999;193:199–211.
Article
PubMed
CAS
Google Scholar
Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc. 1984;134:127–36.
Torres-Platas SG, Comeau S, Rachalski A, Bo GD, Cruceanu C, Turecki G, et al. Morphometric characterization of microglial phenotypes in human cerebral cortex. J Neuroinflammation. 2014;11:12.
Stacklies W, Redestig H, Scholz M, Walther D, Selbig J. pcaMethods—a bioconductor package providing PCA methods for incomplete data. Bioinformatics. 2007;23:1164–7.
Article
PubMed
CAS
Google Scholar
Buddensiek J, Dressel A, Kowalski M, Runge U, Schroeder H, Hermann A, et al. Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation. BMC Neurosci. 2010;11:48.
Article
PubMed
PubMed Central
CAS
Google Scholar
Akoev GN, Chalisova NI, Ludino MI, Terent’ev DA, Yatsuk SL, Romanjuk AV. Epileptiform activity increases the level of nerve growth factor in cerebrospinal fluid of epileptic patients and in hippocampal neurons in tissue culture. Neuroscience. 1996;75:601–5.
Article
PubMed
CAS
Google Scholar
Song JH, Wang CX, Song DK, Wang P, Shuaib A, Hao C. Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway. J Biol Chem. 2005;280:12896–901.
Article
PubMed
CAS
Google Scholar
Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Matrix metalloproteinase-8 is involved in dermal nerve growth: implications for possible application to pruritus from in vitro models. J Invest Dermatol. 2011;131:2105–12.
Article
PubMed
CAS
Google Scholar
Chou DK, Zhang J, Smith FI, McCaffery P, Jungalwala FB. Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration. J Neurochem. 2004;90:1389–401.
Article
PubMed
CAS
Google Scholar
Carmeliet P, Ruiz de Almodovar C. VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration. Cell Mol Life Sci. 2013;70:1763–78.
Article
PubMed
CAS
Google Scholar
Vidaurre OG, Haines JD, Katz Sand I, Adula KP, Huynh JL, McGraw CA, et al. Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Brain. 2014;137:2271–86.
Article
PubMed
PubMed Central
Google Scholar
Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler ZS, et al. The role of inflammation in perinatal brain injury. Nat Rev Neurol. 2015;11:192–208.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zackular JP, Chazin WJ, Skaar EP. Nutritional immunity: S100 proteins at the host-pathogen interface. J Biol Chem. 2015;290:18991–8.
Article
PubMed
PubMed Central
CAS
Google Scholar
Na BR, Kim HR, Piragyte I, Oh HM, Kwon MS, Akber U, et al. TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol. 2015;209:143–62.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sahay B, Patsey RL, Eggers CH, Salazar JC, Radolf JD, Sellati TJ. CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance. PLoS Pathog. 2009;5:e1000687.
Article
PubMed
PubMed Central
CAS
Google Scholar
Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009;37:4587–602.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hu X, Wu R, Shehadeh LA, Zhou Q, Jiang C, Huang X, et al. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics. 2014;15:303.
Article
PubMed
PubMed Central
CAS
Google Scholar
Pichiule P, Chavez JC, Schmidt AM, Vannucci SJ. Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia. J Biol Chem. 2007;282:36330–40.
Article
PubMed
CAS
Google Scholar
Hota SK, Barhwal K, Singh SB, Ilavazhagan G. Chronic hypobaric hypoxia induced apoptosis in CA1 region of hippocampus: a possible role of NMDAR mediated p75NTR upregulation. Exp Neurol. 2008;212:5–13.
Article
PubMed
CAS
Google Scholar
Balschun D, Wetzel W, Del Rey A, Pitossi F, Schneider H, Zuschratter W, et al. Interleukin-6: a cytokine to forget. FASEB J. 2004;18:1788–90.
Article
PubMed
CAS
Google Scholar
Liauw J, Hoang S, Choi M, Eroglu C, Choi M, Sun GH, et al. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab. 2008;28:1722–32.
Article
PubMed
CAS
Google Scholar
Dmytriyeva O, Pankratova S, Owczarek S, Sonn K, Soroka V, Ridley CM, et al. The metastasis-promoting S100A4 protein confers neuroprotection in brain injury. Nat Commun. 2012;3:1197.
Article
PubMed
CAS
Google Scholar
Mikkelsen SE, Novitskaya V, Kriajevska M, Berezin V, Bock E, Norrild B, et al. S100A12 protein is a strong inducer of neurite outgrowth from primary hippocampal neurons. J Neurochem. 2001;79:767–76.
Article
PubMed
CAS
Google Scholar
Martin CR, Dammann O, Allred EN, Patel S, O’Shea TM, Kuban KC, et al. Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremia. J Pediatr. 2010;157:751–6. e1.
Article
PubMed
PubMed Central
Google Scholar
Shah DK, Doyle LW, Anderson PJ, Bear M, Daley AJ, Hunt RW, et al. Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at term. J Pediatr. 2008;153:170–5. e1.
Article
PubMed
Google Scholar
Ejlerskov P, Hultberg JG, Wang J, Carlsson R, Ambjorn M, Kuss M, et al. Lack of neuronal IFN-beta-IFNAR causes lewy body- and parkinson’s disease-like dementia. Cell. 2015;163:324–39.
Article
PubMed
PubMed Central
CAS
Google Scholar
Boulanger LM. Immune proteins in brain development and synaptic plasticity. Neuron. 2009;64:93–109.
Article
PubMed
CAS
Google Scholar
Frese CK, Mikhaylova M, Stucchi R, Gautier V, Liu Q, Mohammed S, et al. Quantitative map of proteome dynamics during neuronal differentiation. Cell Rep. 2017;18:1527–42.
Article
PubMed
PubMed Central
CAS
Google Scholar
Knuesel I, Chicha L, Britschgi M, Schobel SA, Bodmer M, Hellings JA, et al. Maternal immune activation and abnormal brain development across CNS disorders. Nat Rev Neurol. 2014;10:643–60.
Article
PubMed
CAS
Google Scholar
Bhardwaj D, Nager M, Camats J, David M, Benguria A, Dopazo A, et al. Chemokines induce axon outgrowth downstream of hepatocyte growth factor and TCF/beta-catenin signaling. Front Cell Neurosci. 2013;7:52.
Article
PubMed
PubMed Central
CAS
Google Scholar
Stankiewicz AM, Goscik J, Majewska A, Swiergiel AH, Juszczak GR. The effect of acute and chronic social stress on the hippocampal transcriptome in mice. PLoS One. 2015;10:e0142195.
Article
PubMed
PubMed Central
CAS
Google Scholar
Denstaedt SJ, Spencer-Segal JL, Newstead MW, Laborc K, Zhao AP, Hjelmaas A, et al. S100A8/A9 drives neuroinflammatory priming and protects against anxiety-like behavior after sepsis. J Immunol. 2018;200:3188–200.
Article
PubMed
CAS
Google Scholar
Naus S, Richter M, Wildeboer D, Moss M, Schachner M, Bartsch JW. Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem. 2004;279:16083–90.
Article
PubMed
CAS
Google Scholar
Bruinink A, Sidler C, Birchler F. Neurotrophic effects of transferrin on embryonic chick brain and neural retinal cell cultures. Int J Dev Neurosci. 1996;14:785–95.
Article
PubMed
CAS
Google Scholar
Kippert A, Trajkovic K, Fitzner D, Opitz L, Simons M. Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling. BMC Neurosci. 2008;9:40.
Article
PubMed
PubMed Central
CAS
Google Scholar
Osborne BF, Caulfield JI, Solomotis SA, Schwarz JM. Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats. Dev Neurobiol. 2017;77:1221–36.
Article
PubMed
PubMed Central
CAS
Google Scholar
Richter F, Meurers BH, Zhu C, Medvedeva VP, Chesselet MF. Neurons express hemoglobin alpha- and beta-chains in rat and human brains. J Comp Neurol. 2009;515:538–47.
Article
PubMed
PubMed Central
CAS
Google Scholar
Biagioli M, Pinto M, Cesselli D, Zaninello M, Lazarevic D, Roncaglia P, et al. Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proc Natl Acad Sci U S A. 2009;106:15454–9.
Article
PubMed
PubMed Central
Google Scholar
Bellelli A, Brunori M, Miele AE, Panetta G, Vallone B. The allosteric properties of hemoglobin: insights from natural and site directed mutants. Curr Protein Pept Sci. 2006;7:17–45.
Article
PubMed
CAS
Google Scholar
Brown N, Alkhayer K, Clements R, Singhal N, Gregory R, Azzam S, et al. Neuronal hemoglobin expression and its relevance to multiple sclerosis neuropathology. J Mol Neurosci. 2016;59:1–17.
Article
PubMed
PubMed Central
CAS
Google Scholar
Consonni A, Morara S, Codazzi F, Grohovaz F, Zacchetti D. Inhibition of lipopolysaccharide-induced microglia activation by calcitonin gene related peptide and adrenomedullin. Mol Cell Neurosci. 2011;48:151–60.
Article
PubMed
PubMed Central
CAS
Google Scholar
Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, et al. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. EMBO J. 2015;34:1612–29.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ginzel M, Feng X, Kuebler JF, Klemann C, Yu Y, von Wasielewski R, et al. Dextran sodium sulfate (DSS) induces necrotizing enterocolitis-like lesions in neonatal mice. PLoS One. 2017;12:e0182732.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kvietys PR. Chapter 10, gastrointestinal circulation and mucosal pathology I: ischemia/reperfusion. In: The gastrointestinal circulation: Morgan & Claypool Life Sciences, San Rafael, California, USA; 2010. https://www.ncbi.nlm.nih.gov/books/NBK53095/.
Keunen K, van Elburg RM, van Bel F, Benders MJ. Impact of nutrition on brain development and its neuroprotective implications following preterm birth. Pediatr Res. 2015;77:148–55.
Article
PubMed
CAS
Google Scholar
Ehrenkranz RA, Dusick AM, Vohr BR, Wright LL, Wrage LA, Poole WK. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics. 2006;117:1253–61.
Article
PubMed
Google Scholar
Hong CR, Fullerton BS, Mercier CE, Morrow KA, Edwards EM, Ferrelli KR, et al. Growth morbidity in extremely low birth weight survivors of necrotizing enterocolitis at discharge and two-year follow-up. J Pediatr Surg. 2018; https://doi.org/10.1016/j.jpedsurg.2018.02.085.