Nylander A, Hafler DA. Multiple sclerosis. J Clin Invest. 2012;122:1180–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502–17.
Article
CAS
PubMed
Google Scholar
Dobson R, Giovannoni G. Multiple sclerosis - a review. Eur J Neurol. 2019;26:27–40.
Article
CAS
PubMed
Google Scholar
Constantinescu CS, Farooqi N, O'Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol. 2011;164:1079–106.
Article
CAS
PubMed
PubMed Central
Google Scholar
de Alba E. Structure, interactions and self-assembly of ASC-dependent inflammasomes. Arch Biochem Biophys. 2019.
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, et al. The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation. Nat Immunol. 2014;15:727–37.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baroja-Mazo A, Martin-Sanchez F, Gomez AI, Martinez CM, Amores-Iniesta J, Compan V, et al. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 2014;15:738–48.
Article
CAS
PubMed
Google Scholar
Franklin BS, Latz E, Schmidt FI. The intra- and extracellular functions of ASC specks. Immunol Rev. 2018;281:74–87.
Article
CAS
PubMed
Google Scholar
Keane RW, Dietrich WD, de Rivero Vaccari JP. Inflammasome proteins as biomarkers of multiple sclerosis. Front Neurol. 2018;9:135.
Article
PubMed
PubMed Central
Google Scholar
de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW. A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci. 2008;28:3404–14.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kerr N, Garcia-Contreras M, Abbassi S, Mejias NH, Desousa BR, Ricordi C, et al. Inflammasome proteins in serum and serum-derived extracellular vesicles as biomarkers of stroke. Front Mol Neurosci. 2018;11:309.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kerr NA, de Rivero Vaccari JP, Umland O, Bullock MR, Conner GE, Dietrich WD, et al. Human lung cell pyroptosis following traumatic brain injury. Cells. 2019;8.
Lee SW, de Rivero Vaccari JP, Truettner JS, Dietrich WD, Keane RW. The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury. J Neuroinflammation. 2019;16:27.
Article
PubMed
PubMed Central
Google Scholar
Lee SW, Gajavelli S, Spurlock MS, Andreoni C, de Rivero Vaccari JP, Bullock MR, et al. Microglial inflammasome activation in penetrating ballistic-like brain injury. J Neurotrauma. 2018;35:1681–93.
Article
PubMed
PubMed Central
Google Scholar
Funk KE, Mirbaha H, Jiang H, Holtzman DM, Diamond MI. Distinct therapeutic mechanisms of tau antibodies: promoting microglial clearance versus blocking neuronal uptake. J Biol Chem. 2015;290:21652–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ellebedy AH, Lupfer C, Ghoneim HE, DeBeauchamp J, Kanneganti TD, Webby RJ. Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. Proc Natl Acad Sci U S A. 2011;108:2927–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ippagunta SK, Brand DD, Luo J, Boyd KL, Calabrese C, Stienstra R, et al. Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. J Biol Chem. 2010;285:12454–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kolly L, Karababa M, Joosten LA, Narayan S, Salvi R, Petrilli V, et al. Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF. J Immunol. 2009;183:4003–12.
Article
CAS
PubMed
Google Scholar
Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J Immunol. 2010;184:4610–4.
Article
CAS
PubMed
Google Scholar
Soares JL, Oliveira EM, Pontillo A. Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis. Mult Scler Relat Disord. 2019;29:26–34.
Article
PubMed
Google Scholar
Khan N, Kuo A, Brockman DA, Cooper MA, Smith MT. Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain. Inflammopharmacology. 2018;26:77–86.
Article
CAS
PubMed
Google Scholar
Gris D, Ye Z, Iocca HA, Wen H, Craven RR, Gris P, et al. NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol. 2010;185:974–81.
Article
CAS
PubMed
Google Scholar
Inoue M, Williams KL, Gunn MD, Shinohara ML. NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012;109:10480–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Voge NV, Alvarez E. Monoclonal antibodies in multiple sclerosis: present and future. Biomedicines. 2019;7.
Syed YY. Ocrelizumab: a review in multiple sclerosis. CNS Drugs. 2018;32:883–90.
Article
CAS
PubMed
Google Scholar
Chin P, Chan AC. Ocrelizumab: a new therapeutic paradigm for multiple sclerosis: published as part of the biochemistry series “biochemistry to bedside”. Biochemistry. 2018;57:474–6.
Article
CAS
PubMed
Google Scholar
Mulero P, Midaglia L, Montalban X. Ocrelizumab: a new milestone in multiple sclerosis therapy. Ther Adv Neurol Disord. 2018;11:1756286418773025.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gao H, Danzi MC, Choi CS, Taherian M, Dalby-Hansen C, Ellman DG, et al. Opposing functions of microglial and macrophagic TNFR2 in the pathogenesis of experimental autoimmune encephalomyelitis. Cell Rep. 2017;18:198–212.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mejias NH, Martinez CC, Stephens ME, de Rivero Vaccari JP. Contribution of the inflammasome to inflammaging. J Inflamm (Lond). 2018;15:23.
Article
CAS
Google Scholar
Brambilla R, Morton PD, Ashbaugh JJ, Karmally S, Lambertsen KL, Bethea JR. Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination. Glia. 2014;62:452–67.
Article
PubMed
Google Scholar
Lassmann H, van Horssen J, Mahad D. Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol. 2012;8:647–56.
Article
CAS
PubMed
Google Scholar
Kerr N, Lee SW, Perez-Barcena J, Crespi C, Ibanez J, Bullock MR, et al. Inflammasome proteins as biomarkers of traumatic brain injury. PLoS One. 2018;13:e0210128.
Article
PubMed
PubMed Central
Google Scholar
Adamczak S, Dale G, de Rivero Vaccari JP, Bullock MR, Dietrich WD, Keane RW. Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article. J Neurosurg. 2012;117:1119–25.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gessner JE, Heiken H, Tamm A, Schmidt RE. The IgG fc receptor family. Ann Hematol. 1998;76:231–48.
Article
CAS
PubMed
Google Scholar
Ryman JT, Meibohm B. Pharmacokinetics of monoclonal antibodies. CPT Pharmacometrics Syst Pharmacol. 2017;6:576–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Garcia-Garcia E, Rosales C. Signal transduction during fc receptor-mediated phagocytosis. J Leukoc Biol. 2002;72:1092–108.
CAS
PubMed
Google Scholar
Metzger H, Kinet JP. How antibodies work: focus on fc receptors. FASEB J. 1988;2:3–11.
Article
CAS
PubMed
Google Scholar
Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, et al. Antibody-aided clearance of extracellular alpha-synuclein prevents cell-to-cell aggregate transmission. J Neurosci. 2012;32:13454–69.
Article
CAS
PubMed
PubMed Central
Google Scholar
He Y, Hara H, Nunez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41:1012–21.
Article
CAS
PubMed
Google Scholar
van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA. Inflammasome activation and IL-1beta and IL-18 processing during infection. Trends Immunol. 2011;32:110–6.
Article
PubMed
CAS
Google Scholar
Evavold CL, Kagan JC. How inflammasomes inform adaptive immunity. J Mol Biol. 2018;430:217–37.
Article
CAS
PubMed
Google Scholar
Mills KH, Dungan LS, Jones SA, Harris J. The role of inflammasome-derived IL-1 in driving IL-17 responses. J Leukoc Biol. 2013;93:489–97.
Article
CAS
PubMed
Google Scholar
Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009;30:576–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, et al. The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem. 2011;286:19605–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Veldhuijzen van Zanten SEM, De Witt Hamer PC, van Dongen GAMS. Brain access of monoclonal antibodies as imaged and quantified by 89Zr-antibody PET: perspectives for treatment of brain diseases. J Nucl Med. 2019;60:615–6.
Article
CAS
PubMed
Google Scholar
Dong X. Current strategies for brain drug delivery. Theranostics. 2018;8:1481–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cheung Y, Desse S, Martinez A, Worthen RJ, Jope RS, Beurel E. TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice. Brain Behav Immun. 2018;69:556–67.
Article
CAS
Google Scholar
de Rivero Vaccari JP, Lotocki G, Alonso OF, Bramlett HM, Dietrich WD, Keane RW. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab. 2009;29:1251–61.
Article
PubMed
CAS
Google Scholar