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  1. Friedreich’s ataxia is a rare hereditary neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Similar to other neurodegenerative pathologies, previous studies suggested t...

    Authors: Andrés Vicente-Acosta, Alfredo Giménez-Cassina, Javier Díaz-Nido and Frida Loria
    Citation: Journal of Neuroinflammation 2022 19:93
  2. Perioperative neurocognitive disorders (PNDs) are common complications observed among surgical patients. Accumulating evidence suggests that neuroinflammation is one of the major contributors to the developmen...

    Authors: Xuwu Xiang, Xiaodong Tang, Yang Yu, Shulan Xie, Lu Liu, ManLi Chen, Rong Zhang, Xianhui Kang, Yueying Zheng, Guang Yang, Shuyuan Gan and Shengmei Zhu
    Citation: Journal of Neuroinflammation 2022 19:92
  3. The mechanisms underlying dysfunction of choroid plexus (ChP) blood–cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood. In this study, we...

    Authors: Jun Wang, Ruijia Liu, Md Nabiul Hasan, Sydney Fischer, Yang Chen, Matt Como, Victoria M. Fiesler, Mohammad Iqbal H. Bhuiyan, Shuying Dong, Eric Li, Kristopher T. Kahle, Jinwei Zhang, Xianming Deng, Arohan R. Subramanya, Gulnaz Begum, Yan Yin…
    Citation: Journal of Neuroinflammation 2022 19:91
  4. Corneal immune cells interact with corneal sensory nerves during both homeostasis and inflammation. This study sought to evaluate temporal changes to corneal immune cell density in a mouse model of epithelial ...

    Authors: Mengliang Wu, Laura E. Downie, Lisa J. Hill and Holly R. Chinnery
    Citation: Journal of Neuroinflammation 2022 19:90
  5. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. We aimed to prospectivel...

    Authors: Yaling Lu, Yu Zhao, Qi Zhang, Chongquan Fang, Anran Bao, Wenjing Dong, Yanbo Peng, Hao Peng, Zhong Ju, Jiang He, Yonghong Zhang, Tan Xu and Chongke Zhong
    Citation: Journal of Neuroinflammation 2022 19:88
  6. Chronic morphine exposure induces immunosuppression in the peripheral and central nervous system, resulting in susceptibility of patients to invading pathogens. Mitophagy is a crucial regulator of inflammation...

    Authors: Jialing Peng, Jingrui Pan, Hongxuan Wang, Jingjing Mo, Lihuan Lan and Ying Peng
    Citation: Journal of Neuroinflammation 2022 19:87
  7. miR-203 was first indicated in maintaining skin homeostasis and innate immunity. Aberrant expression of miR-203 was found associated with pathological progressions of immune disorders, cancers, as well as neur...

    Authors: Shufang Li, Linpeng Li, Jieli Li, Xiaosheng Liang, Chao Song and Yi Zou
    Citation: Journal of Neuroinflammation 2022 19:84
  8. Ischemic stroke is a medical emergency that primarily affects the elderly. A complex immune response in the post-stroke brain constitutes a key component of stroke pathophysiology. This study aimed to determin...

    Authors: Xuan Li, Jingjun Lyu, Ran Li, Vaibhav Jain, Yuntian Shen, Ángela del Águila, Ulrike Hoffmann, Huaxin Sheng and Wei Yang
    Citation: Journal of Neuroinflammation 2022 19:83
  9. Neuroinflammation is a crucial factor in the development of secondary brain injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers strong neuroprotective effects in expe...

    Authors: Yao Wang, Mi Tian, Jiaying Tan, Xu Pei, Chaocheng Lu, Yuewen Xin, Shuixiang Deng, Feng Zhao, Yanqin Gao and Ye Gong
    Citation: Journal of Neuroinflammation 2022 19:82
  10. Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized. We sought ...

    Authors: Olus Uyar, Juan Manuel Dominguez, Maude Bordeleau, Lina Lapeyre, Fernando González Ibáñez, Luc Vallières, Marie-Eve Tremblay, Jacques Corbeil and Guy Boivin
    Citation: Journal of Neuroinflammation 2022 19:81
  11. Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)...

    Authors: Chi Zhang, Yong Huang, Fubing Ouyang, Minzhi Su, Wenbiao Li, Jialiang Chen, Hengjun Xiao, Xiangfu Zhou and Bolong Liu
    Citation: Journal of Neuroinflammation 2022 19:80
  12. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been described as a biomarker for microglial activation, which were observed increased in a variety of neurolo...

    Authors: Ming-Hao Dong, Luo-Qi Zhou, Yue Tang, Man Chen, Jun Xiao, Ke Shang, Gang Deng, Chuan Qin and Dai-Shi Tian
    Citation: Journal of Neuroinflammation 2022 19:79
  13. Macular subretinal fibrosis is the end-stage complication of neovascular age-related macular degeneration (nAMD). We previously developed a mouse model of two-stage laser-induced subretinal fibrosis that mimic...

    Authors: Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen and Heping Xu
    Citation: Journal of Neuroinflammation 2022 19:78
  14. Cognitive impairment is one of the primary sequelae affecting the quality of life of patients with Japanese encephalitis (JE). The clinical treatment is mainly focused on life support, lacking of targeted trea...

    Authors: Rong Yin, Linpeng Yang, Ying Hao, Zhiqi Yang, Tao Lu, Wanjun Jin, Meiling Dan, Liang Peng, Yingjie Zhang, Yaxuan Wei, Rong Li, Huiping Ma, Yuanyuan Shi and Pengcheng Fan
    Citation: Journal of Neuroinflammation 2022 19:77
  15. Poststroke cognitive impairment (PSCI) is prevalent in stroke patients. The etiology of PSCI remains largely unknown. We previously found that stroke induces gut microbiota dysbiosis which affects brain injury...

    Authors: Huidi Wang, Mingsi Zhang, Jie Li, Jianhai Liang, Mengjia Yang, Genghong Xia, Yueran Ren, Hongwei Zhou, Qiheng Wu, Yan He and Jia Yin
    Citation: Journal of Neuroinflammation 2022 19:76
  16. Ketamine, a multimodal dissociative anesthetic drug, is widely used as an analgesic following traumatic injury. Although ketamine may produce anti-inflammatory effects when administered after injury, the immun...

    Authors: Haley F. Spencer, Rina Y. Berman, Martin Boese, Michael Zhang, Sharon Y. Kim, Kennett D. Radford and Kwang H. Choi
    Citation: Journal of Neuroinflammation 2022 19:75
  17. We recently reported increased levels of neutrophils, monocytes and C-reactive protein (CRP) correlated with symptom severity in acute schizophrenia. Here, we investigated if a similar pattern of innate immune...

    Authors: Deepti Singh, Paul C. Guest, Henrik Dobrowolny, Veronika Vasilevska, Gabriela Meyer-Lotz, Hans-Gert Bernstein, Katrin Borucki, Alexandra Neyazi, Bernhard Bogerts, Roland Jacobs and Johann Steiner
    Citation: Journal of Neuroinflammation 2022 19:74
  18. Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to b...

    Authors: Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain and Keith A. Sharkey
    Citation: Journal of Neuroinflammation 2022 19:73
  19. Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive ...

    Authors: Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan, Aleksandar Dobric, Kevin Mou, Huei Jiunn Seow and Ross Vlahos
    Citation: Journal of Neuroinflammation 2022 19:72
  20. After traumatic brain injury (TBI), an acute, robust inflammatory cascade occurs that is characterized by the activation of resident cells such as microglia, the migration and recruitment of peripheral immune ...

    Authors: Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin and Ye Xiong
    Citation: Journal of Neuroinflammation 2022 19:71
  21. The etiology of Rasmussen's encephalitis (RE), a rare chronic neurological disorder characterized by CD8+ T cell infiltration and unihemispheric brain atrophy, is still unknown. Various human herpes viruses (H...

    Authors: Yi-Song Wang, Dong Liu, Xin Wang, Qiao-Li Luo, Ling Ding, Dong-Ying Fan, Qi-Liang Cai, Chong-Yang Tang, Wei Yang, Yu-Guang Guan, Tian-Fu Li, Pei-Gang Wang, Guo-Ming Luan and Jing An
    Citation: Journal of Neuroinflammation 2022 19:70
  22. Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incomplet...

    Authors: Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting and Holly L. Rosenzweig
    Citation: Journal of Neuroinflammation 2022 19:69
  23. Peripheral nerve injuries are accompanied by inflammatory reactions, over-activation of which may hinder recovery. Among pro-inflammatory pathways, inflammasomes are one of the most potent, leading to release ...

    Authors: Kinga Molnár, Bernát Nógrádi, Rebeka Kristóf, Ádám Mészáros, Krisztián Pajer, László Siklós, Antal Nógrádi, Imola Wilhelm and István A. Krizbai
    Citation: Journal of Neuroinflammation 2022 19:68
  24. Inflammation induced by intracerebral hemorrhage (ICH) is one of the main causes of the high mortality and poor prognosis of patients with ICH. A1 astrocytes are closely associated with neuroinflammation and n...

    Authors: Xiaowei Fei, Ya-nan Dou, Li Wang, Xiuquan Wu, Yu Huan, Shuang Wu, Xin He, Weihao Lv, Jialiang Wei and Zhou Fei
    Citation: Journal of Neuroinflammation 2022 19:67
  25. Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1 encephalitis. Recent reports focus on the significance of thrombomoduli...

    Authors: Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu and Shun-Hua Chen
    Citation: Journal of Neuroinflammation 2022 19:66
  26. Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity an...

    Authors: Dominika Pilat, Jean-Michel Paumier, Laura García-González, Laurence Louis, Delphine Stephan, Christine Manrique, Michel Khrestchatisky, Eric Di Pasquale, Kévin Baranger and Santiago Rivera
    Citation: Journal of Neuroinflammation 2022 19:65
  27. Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact ...

    Authors: Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia and Xiaoping Gu
    Citation: Journal of Neuroinflammation 2022 19:64
  28. Glaucoma is a blinding degenerative neuropathy in which the death of retinal ganglion cells (RGCs) causes progressive loss of visual field and eventually vision. Neuroinflammation appears to be a key event in ...

    Authors: Élodie Reboussin, Juliette Buffault, Françoise Brignole-Baudouin, Annabelle Réaux-Le Goazigo, Luisa Riancho, Céline Olmiere, José-Alain Sahel, Stéphane Mélik Parsadaniantz and Christophe Baudouin
    Citation: Journal of Neuroinflammation 2022 19:63
  29. Neuromyelitis optica spectrum disorder (NMOSD) attacks require an urgent probabilistic anti-inflammatory therapeutic strategy. As inadequately treated attacks result in disability, there is a need to identify ...

    Authors: Stanislas Demuth, Maxime Guillaume, Bertrand Bourre, Jonathan Ciron, Hélène Zephir, Yoann Sirejacob, Anne Kerbrat, Christine Lebrun-Frenay, Caroline Papeix, Laure Michel, David Laplaud, Sandra Vukusic, Elisabeth Maillart, Mikael Cohen, Bertrand Audoin, Romain Marignier…
    Citation: Journal of Neuroinflammation 2022 19:62
  30. Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an essential role in selectively retrieval of transmembrane proteins from endosomes to trans-Golgi networks. Dysfunctional retromer i...

    Authors: Xiao Ren, Lingling Yao, YongGang Wang, Lin Mei and Wen-Cheng Xiong
    Citation: Journal of Neuroinflammation 2022 19:61
  31. We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve segment are the most common type of traumatic injury to nervous systems. Segmental-loss PNIs have a poor prognosis ...

    Authors: George D. Bittner, Jared S. Bushman, Cameron L. Ghergherehchi, Kelly C. S. Roballo, Jaimie T. Shores and Tyler A. Smith
    Citation: Journal of Neuroinflammation 2022 19:60
  32. The transcription factor Sox2 plays important roles in the developmental processes of multiple organs and tissues. However, whether Sox2 can protect mature or terminally differentiated cells against injury is ...

    Authors: Diyan Chen, Gaogan Jia, Yanping Zhang, Huanyu Mao, Liping Zhao, Wenyan Li, Yan Chen and Yusu Ni
    Citation: Journal of Neuroinflammation 2022 19:59
  33. Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterised by the loss of upper and lower motor neurons. Increasing evidence indicates that neuroinflammation mediated by mi...

    Authors: Hazel Quek, Carla Cuní-López, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Tam Hong Nguyen, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Tara L. Roberts, Yi Chieh Lim, Lotta E. Oikari, Vincenzo La Bella and Anthony R. White
    Citation: Journal of Neuroinflammation 2022 19:58
  34. Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegener...

    Authors: Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand V. Germanwala, Nigel A. Calcutt and Virginie Mansuy-Aubert
    Citation: Journal of Neuroinflammation 2022 19:57
  35. Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG repeats exceeds 36, the translated expanded polyglutamine-c...

    Authors: Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu and Tz-Chuen Ju
    Citation: Journal of Neuroinflammation 2022 19:56
  36. Classical understanding of allergic conjunctivitis (ACJ) suggests that ocular itch results from a mast cell-dependent inflammatory process. However, treatments that target inflammatory mediators or immune cell...

    Authors: Huan Cui, Fan Liu, Yehong Fang, Tao Wang, Bo Yuan and Chao Ma
    Citation: Journal of Neuroinflammation 2022 19:55
  37. In the field of autoimmune demyelinating diseases, visual impairments have extensively been studied using the experimental autoimmune encephalomyelitis (EAE) mouse model, which is classically induced by immuni...

    Authors: Sandrine Joly, Julius Baya Mdzomba, Léa Rodriguez, Françoise Morin, Luc Vallières and Vincent Pernet
    Citation: Journal of Neuroinflammation 2022 19:54
  38. Immune system dysfunction, including higher levels of peripheral monocytes and inflammatory cytokines, is an important feature of Parkinson’s disease (PD) pathogenesis, although the mechanism underlying the pr...

    Authors: Zongran Liu, Robin Barry Chan, Zhijian Cai, Xiaodan Liu, Yufeng Wu, Zhenwei Yu, Tao Feng, Ying Yang and Jing Zhang
    Citation: Journal of Neuroinflammation 2022 19:53
  39. Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeu...

    Authors: Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal and Jiang-fan Chen
    Citation: Journal of Neuroinflammation 2022 19:52
  40. Traumatic brain injury (TBI) is a kind of acquired brain injury, which is caused by external mechanical forces. Moreover, the neuroprotective role of sevoflurane (Sevo) has been identified in TBI. Therefore, t...

    Authors: Zhongyu Wang, Zhaoyang Wang, Anqi Wang, Juan Li, Junmin Wang, Jingjing Yuan, Xin Wei, Fei Xing, Wei Zhang and Na Xing
    Citation: Journal of Neuroinflammation 2022 19:51
  41. Parkinson’s disease (PD) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation. Degenerating ...

    Authors: Adrianne F. Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A. C. Herrebout, Mona M. H. E. Fayed, Michele Sandre, Tatiana Varanita, Charlotte E. Teunissen, Jeroen J. M. Hoozemans, Arianna Bellucci, Robert Veerhuis and Luigi Bubacco
    Citation: Journal of Neuroinflammation 2022 19:50
  42. Intracerebral hemorrhage (ICH) is a significant cause of death and disabilities. Recently, cell therapies using mesenchymal stem cells have been shown to improve ICH-induced neurobehavioral deficits. Based on ...

    Authors: Yoji Kuramoto, Mitsugu Fujita, Toshinori Takagi, Yuki Takeda, Nobutaka Doe, Kenichi Yamahara and Shinichi Yoshimura
    Citation: Journal of Neuroinflammation 2022 19:48
  43. Ischemic stroke induces the activation and recruitment of peripheral leukocytes to the injured brain. These cells can infiltrate the brain through multiple routes, either by penetrating blood–brain barrier or ...

    Authors: Aditya Rayasam, Amin Mottahedin, Joel Faustino, Carina Mallard and Zinaida S. Vexler
    Citation: Journal of Neuroinflammation 2022 19:47
  44. Traumatic brain injury (TBI) remains one of the main causes for disability and death worldwide. While the primary mechanical injury cannot be avoided, the prevention of secondary injury is the focus of TBI res...

    Authors: Zhimin Zou, Li Li, Qin Li, Peng Zhao, Kun Zhang, Chengyong Liu, Daozhang Cai, Marc Maegele, Zhengtao Gu and Qiaobing Huang
    Citation: Journal of Neuroinflammation 2022 19:46
  45. There are over 15 disease-modifying drugs that have been approved over the last 20 years for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited treatment options available for ...

    Authors: Emily Kamma, Wendy Lasisi, Cole Libner, Huah Shin Ng and Jason R. Plemel
    Citation: Journal of Neuroinflammation 2022 19:45
  46. Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the simila...

    Authors: Ivan L. Salazar, Ana S. T. Lourenço, Bruno Manadas, Inês Baldeiras, Cláudia Ferreira, Anabela Claro Teixeira, Vera M. Mendes, Ana Margarida Novo, Rita Machado, Sónia Batista, Maria do Carmo Macário, Mário Grãos, Lívia Sousa, Maria João Saraiva, Alberto A. C. C. Pais and Carlos B. Duarte
    Citation: Journal of Neuroinflammation 2022 19:44
  47. Tissue damage and cellular destruction are the major events in traumatic brain injury (TBI), which trigger sterile neuroimmune and neuroinflammatory responses in the brain. While appropriate acute and transien...

    Authors: Xiang Gao, Wei Li, Fahim Syed, Fang Yuan, Ping Li and Qigui Yu
    Citation: Journal of Neuroinflammation 2022 19:43
  48. Mounting evidences indicate that oxidative stress, neuroinflammation, and dysregulation of gut microbiota are related to neurodegenerative disorders (NDs). Butyrolactone I (BTL-I), a marine fungal metabolite, ...

    Authors: Yingying Nie, Jingming Yang, Longjian Zhou, Zhiyou Yang, Jinyue Liang, Yayue Liu, Xiaoxiang Ma, Zhongji Qian, Pengzhi Hong, Allan V. Kalueff, Cai Song and Yi Zhang
    Citation: Journal of Neuroinflammation 2022 19:39
  49. Neuroinflammation and apoptosis are involved in the pathogenesis of ischaemic stroke. Alisol A 24-acetate (24A) exerts a strong inhibitory effect on inflammation and cell apoptosis. The neuroprotective effect ...

    Authors: Taotao Lu, Huihong Li, Yangjie Zhou, Wei Wei, Linlin Ding, Zengtu Zhan, Weilin Liu, Jing Tao and Xiehua Xue
    Citation: Journal of Neuroinflammation 2022 19:37

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