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  1. Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and is associated with poor outcome in the early phase of se...

    Authors: Nils Mein, Nikolai von Stackelberg, Jonathan Wickel, Christian Geis and Ha-Yeun Chung
    Citation: Journal of Neuroinflammation 2023 20:289
  2. Authors: Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan and Adam D. Bachstetter
    Citation: Journal of Neuroinflammation 2023 20:287

    The original article was published in Journal of Neuroinflammation 2023 20:248

  3. Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lyso...

    Authors: Drew A. Gillett, Rebecca L. Wallings, Oihane Uriarte Huarte and Malú Gámez Tansey
    Citation: Journal of Neuroinflammation 2023 20:286
  4. Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention an...

    Authors: Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu and Yanni Lv
    Citation: Journal of Neuroinflammation 2023 20:285
  5. Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). It has been reported that TRIM45 is associated with tumours and inflammatory diseases. H...

    Authors: Xuliang Huang, Changzhou Ye, Xinyu Zhao, Yao Tong, Wen Lin, Qingqing Huang, Yuhao Zheng, Junlu Wang, Anqi Zhang and Yunchang Mo
    Citation: Journal of Neuroinflammation 2023 20:284
  6. The gut microbiota has recently attracted attention as a pathogenic factor in Alzheimer’s disease (AD). Microfold (M) cells, which play a crucial role in the gut immune response against external antigens, are ...

    Authors: Namkwon Kim, In Gyoung Ju, Seung Ho Jeon, Yeongae Lee, Min-Ji Jung, Min Sung Gee, Jae Seok Cho, Kyung-Soo Inn, Lee Ann Garrett-Sinha, Myung Sook Oh and Jong Kil Lee
    Citation: Journal of Neuroinflammation 2023 20:282
  7. Inflammatory response triggered by innate immunity plays a pivotal element in the progress of ischemic stroke. Receptor-interacting kinase 2 (RIP2) is implicated in maintaining immunity homeostasis and regulat...

    Authors: Shengnan Zheng, Yiquan Li, Xiaomeng Song, Mengting Wu, Lu Yu, Gan Huang, Tengfei Liu, Lei Zhang, Mingmei Shang, Qingfen Zhu, Chengjiang Gao, Lin Chen and Huiqing Liu
    Citation: Journal of Neuroinflammation 2023 20:281
  8. Neonatal encephalopathy following hypoxia–ischemia (HI) is a leading cause of childhood death and morbidity. Hypothermia (HT), the only available but obligatory therapy is limited due to a short therapeutic wi...

    Authors: Nicole Labusek, Parnian Ghari, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Martin Hadamitzky, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel and Josephine Herz
    Citation: Journal of Neuroinflammation 2023 20:280
  9. Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascularization (CNV), and AMD is the leading cause of irreversible vision impairment in older ...

    Authors: Yu-Hsien Chang, Chung-Hsi Hsing, Chiao-Juno Chiu, Yi-Rou Wu, Sheng-Min Hsu and Yu-Hsiang Hsu
    Citation: Journal of Neuroinflammation 2023 20:279
  10. Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer’s disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accum...

    Authors: Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari…
    Citation: Journal of Neuroinflammation 2023 20:278
  11. Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation i...

    Authors: Wei Bi, Keyao Bao, Xinqi Zhou, Yihui Deng, Xiaoting Li, Jiawei Zhang, Xin Lan, Jiayi Zhao, Daxiang Lu, Yezi Xu, Yanmei Cen, Rui Cao, Mengyang Xu, Wenbin Zhong and Lihong Zhu
    Citation: Journal of Neuroinflammation 2023 20:277
  12. Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodegenerative disorders, including Huntington’s disease (HD). HD is a genetic condition caus...

    Authors: Noam Steinberg, Danny Galleguillos, Asifa Zaidi, Melanie Horkey and Simonetta Sipione
    Citation: Journal of Neuroinflammation 2023 20:276
  13. Regulatory T cells (Tregs) are involved in the systemic immune response after ischemic stroke. However, their role remains unclear, and the effect appears to be both neuroprotective and detrimental. Treg suppr...

    Authors: Maria Lukasik, Magdalena Telec, Radoslaw Kazmierski, Izabela Wojtasz, Natalia Andrzejewska-Gorczyńska, Wojciech Kociemba, Grzegorz Dworacki, Wojciech P. Kozubski and Magdalena Frydrychowicz
    Citation: Journal of Neuroinflammation 2023 20:275
  14. Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered a potential susceptibility gene for Parkinson’s disease (PD), and has been demonstrated to possess protective effects ...

    Authors: Tianbai Li, Xiang Tan, Lulu Tian, Congcong Jia, Cheng Cheng, Xi Chen, Min Wei, Yuanyuan Wang, Yiying Hu, Qiqi Jia, Yang Ni, Murad Al-Nusaif, Song Li and Weidong Le
    Citation: Journal of Neuroinflammation 2023 20:274
  15. Traumatic spinal cord injury can cause immediate physical damage to the spinal cord and result in severe neurological deficits. The primary, mechanical tissue damage triggers a variety of secondary damage mech...

    Authors: Marie-Kim St-Pierre, Fernando González Ibáñez, Antje Kroner and Marie-Ève Tremblay
    Citation: Journal of Neuroinflammation 2023 20:273
  16. Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer’s disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer’s disease. TREM2 i...

    Authors: Oliver Cousins, Julia J. Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O’Neill, David Collier…
    Citation: Journal of Neuroinflammation 2023 20:272
  17. Subarachnoid hemorrhage (SAH) is an uncommon type of potentially fatal stroke. The pathophysiological mechanisms of brain injury remain unclear, which hinders the development of drugs for SAH. We aimed to inve...

    Authors: Huaijun Chen, Chaoran Xu, Hanhai Zeng, Zhihua Zhang, Ning Wang, Yinghan Guo, Yonghe Zheng, Siqi Xia, Hang Zhou, Xiaobo Yu, Xiongjie Fu, Tianchi Tang, Xinyan Wu, Zihang Chen, Yucong Peng, Jing Cai…
    Citation: Journal of Neuroinflammation 2023 20:270
  18. Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regi...

    Authors: Jessica R. Gaunt, Norliyana Zainolabidin, Alaric K. K. Yip, Jia Min Tan, Aloysius Y. T. Low, Albert I. Chen and Toh Hean Ch’ng
    Citation: Journal of Neuroinflammation 2023 20:269
  19. Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-inflammatory, and antitumor properties. However, as the effects of C3G on the amyloidogenic pathway, autophagy, tau phosphorylation,...

    Authors: Hana Baek, Sanjay, Miey Park and Hae-Jeung Lee
    Citation: Journal of Neuroinflammation 2023 20:268
  20. Brain pericytes participate in the regulation of cerebral blood flow and the maintenance of blood–brain barrier integrity. Because of their perivascular localization, their receptor repertoire, and their poten...

    Authors: Nina C. Teske, Susanne Dyckhoff-Shen, Paul Beckenbauer, Jan Philipp Bewersdorf, Joo-Yeon Engelen-Lee, Sven Hammerschmidt, Roland E. Kälin, Hans-Walter Pfister, Matthijs C. Brouwer, Matthias Klein, Rainer Glass, Diederik van de Beek and Uwe Koedel
    Citation: Journal of Neuroinflammation 2023 20:267
  21. Cochlear implants (CIs) restore hearing to deafened patients. The foreign body response (FBR) following cochlear implantation (post-CI) comprises an infiltration of macrophages, other immune and non-immune cel...

    Authors: Muhammad Taifur Rahman, Brian J. Mostaert, Bryce Hunger, Utsow Saha, Alexander D. Claussen, Ibrahim Razu, Farjana Nasrin, Nashwaan Ali Khan, Peter Eckard, Sarah Coleman, Jacob Oleson, Jonathon R. Kirk, Keiko Hirose and Marlan R. Hansen
    Citation: Journal of Neuroinflammation 2023 20:266
  22. Cerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows that the interaction between oxidatively stressed red blood cells (RBC) and cerebral en...

    Authors: Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher and Xiangmin Xu
    Citation: Journal of Neuroinflammation 2023 20:265
  23. Lipid metabolism has a crucial role in neural repair in neurodegenerative diseases. We recently revealed that lipogenesis-mediated interleukin-33 (IL-33) upregulation lead to blood–brain barrier (BBB) repair a...

    Authors: Haidong Wei, Luming Zhen, Shiquan Wang, Liufei Yang, Shuyue Zhang, Yuanyuan Zhang, Pengyu Jia, Tianyue Wang, Kui Wang, Yan Zhang, Lei Ma, Jianrui Lv and Pengbo Zhang
    Citation: Journal of Neuroinflammation 2023 20:264
  24. The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was used in combination with a Cav1.2 conditional knock-out mouse (Cav1.2KO) to study the role of astrocytic voltage-gated Ca++ chan...

    Authors: G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang and P. M. Paez
    Citation: Journal of Neuroinflammation 2023 20:263
  25. Ongoing neuroaxonal damage is a major contributor to disease progression and long-term disability in multiple sclerosis. However, spatio-temporal distribution and pathophysiological mechanisms of neuroaxonal d...

    Authors: Tobias Brummer, Miriam Schillner, Falk Steffen, Flores Kneilmann, Beatrice Wasser, Timo Uphaus, Frauke Zipp and Stefan Bittner
    Citation: Journal of Neuroinflammation 2023 20:262
  26. Subarachnoid hemorrhage (SAH) causes significant long-term neurocognitive dysfunction, which is associated with hippocampal neuroinflammation. Growing evidences have shown that astrocytes played a significant ...

    Authors: Ping Chen, Xue-Yan Liu, Mou-Hui Lin, Yu-Xi Li, De-Zhi Kang, Zu-Cheng Ye and Qing-Song Lin
    Citation: Journal of Neuroinflammation 2023 20:261
  27. Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secrete...

    Authors: Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu and Xiang Cao
    Citation: Journal of Neuroinflammation 2023 20:260
  28. Spinal cord injury (SCI) can prompt an immediate disruption to the blood–spinal cord barrier (BSCB). Restoring the integrity of this barrier is vital for the recovery of neurological function post-SCI. The UTX...

    Authors: Yong Xie, Zixiang Luo, Wei Peng, Yudong Liu, Feifei Yuan, Jiaqi Xu, Yi Sun, Hongbin Lu, Tianding Wu, Liyuan Jiang and Jianzhong Hu
    Citation: Journal of Neuroinflammation 2023 20:259
  29. Although peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a well-established fact that macrophages accumulate at the site of injury. ...

    Authors: Eri Oshima, Yoshinori Hayashi, Zhen Xie, Hitoshi Sato, Suzuro Hitomi, Ikuko Shibuta, Kentaro Urata, Junjun Ni, Koichi Iwata, Tatsuo Shirota and Masamichi Shinoda
    Citation: Journal of Neuroinflammation 2023 20:258
  30. This study investigated chronic and repeated sleep deprivation (RSD)-induced neuronal changes in hexosamine biosynthetic pathway/O-linked N-acetylglucosamine (HBP/O-GlcNAc) cycling of glucose metabolism and furth...

    Authors: Jiwon Park, Dong Yeol Kim, Geum-Sook Hwang and Inn-Oc Han
    Citation: Journal of Neuroinflammation 2023 20:257
  31. Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production o...

    Authors: Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang and Michelle H. Theus
    Citation: Journal of Neuroinflammation 2023 20:256
  32. Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric glio...

    Authors: Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, Jörg C. Kalff and Sven Wehner
    Citation: Journal of Neuroinflammation 2023 20:255
  33. Authors: Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott and M. Kerry O’Banion
    Citation: Journal of Neuroinflammation 2023 20:254

    The original article was published in Journal of Neuroinflammation 2022 19:38

  34. Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have b...

    Authors: Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick and Michele D. Binder
    Citation: Journal of Neuroinflammation 2023 20:253
  35. Inflammation during pregnancy is associated with an increased risk for neurodevelopmental disorders (NDD). Increased gestational inflammation can be a result of an immune condition/disease, exposure to infecti...

    Authors: Juan M. Tamayo, Hadley C. Osman, Jared J. Schwartzer, Kent E. Pinkerton and Paul Ashwood
    Citation: Journal of Neuroinflammation 2023 20:252
  36. Disruption of the extracellular matrix at the blood–brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix components, such as heparan sulfate (HS) ...

    Authors: Tessa Peck, Connor Davis, Georgia Lenihan-Geels, Maddie Griffiths, Sam Spijkers-Shaw, Olga V. Zubkova and Anne Camille La Flamme
    Citation: Journal of Neuroinflammation 2023 20:251
  37. Childhood represents a period of significant growth and maturation for the brain, and is also associated with a heightened risk for mild traumatic brain injuries (mTBI). There is also concern that repeated-mTB...

    Authors: Katie J. Neale, Hannah M. O. Reid, Barbara Sousa, Erin McDonagh, Jamie Morrison, Sandy Shultz, Eric Eyolfson and Brian R. Christie
    Citation: Journal of Neuroinflammation 2023 20:250
  38. Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, in which neuroinflammation is a critical pathological contributor. Slit2, a secreted extracellular matrix protein, plays a repulsive role in a...

    Authors: Qian Li, Lei Huang, Yan Ding, Prativa Sherchan, Wenjie Peng and John H. Zhang
    Citation: Journal of Neuroinflammation 2023 20:249
  39. Neuroinflammation contributes to secondary injury cascades following traumatic brain injury (TBI), with alternating waves of inflammation and resolution. Interleukin-1 (IL-1), a critical neuroinflammatory medi...

    Authors: Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan and Adam D. Bachstetter
    Citation: Journal of Neuroinflammation 2023 20:248

    The Correction to this article has been published in Journal of Neuroinflammation 2023 20:287

  40. The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human t...

    Authors: Shuo Kong, Tao-xiang Chen, Xiang-lei Jia, Xue-lei Cheng, Meng-liu Zeng, Jing-yi Liang, Xiao-hua He, Jun Yin, Song Han, Wan-hong Liu, Yuan-teng Fan, Ting Zhou, Yu-min Liu and Bi-wen Peng
    Citation: Journal of Neuroinflammation 2023 20:247
  41. Peripheral facial palsy (PFP) is a common neurologic symptom which can be triggered by pathogens, autoimmunity, trauma, tumors, cholesteatoma or further local conditions disturbing the peripheral section of th...

    Authors: Leyla Mohammad, Mathias Fousse, Gentiana Wenzel, Marina Flotats Bastardas, Klaus Faßbender, Ulrich Dillmann, Bernhard Schick, Michael Zemlin, Barbara C. Gärtner, Urban Sester, David Schub, Tina Schmidt and Martina Sester
    Citation: Journal of Neuroinflammation 2023 20:246
  42. Homozygous CD59-deficient patients manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), hemolytic anemia and recurrent strokes. Variable mutations in CD59 leading to loss of ...

    Authors: Netanel Karbian, Yael Eshed-Eisenbach, Marian Zeibak, Adi Tabib, Natasha Sukhanov, Anya Vainshtein, B. Paul Morgan, Yakov Fellig, Elior Peles and Dror Mevorach
    Citation: Journal of Neuroinflammation 2023 20:245
  43. Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) dise...

    Authors: Shan Meng, Hui Cao, Yichen Huang, Ziyu Shi, Jiaying Li, Yana Wang, Yue Zhang, Shuning Chen, Hong Shi and Yanqin Gao
    Citation: Journal of Neuroinflammation 2023 20:244
  44. Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS). Resulting myelin debris hinders repair if not effectively sc...

    Authors: Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal and Shlomo Rotshenker
    Citation: Journal of Neuroinflammation 2023 20:243
  45. Microglia, the primary immune cells of the central nervous system (CNS), are derived from the yolk sac and populate the brain during development. Once microglia migrate to the CNS, they are self-renewing and r...

    Authors: Akhabue K. Okojie, Joseph O. Uweru, Morgan A. Coburn, Sihan Li, Vivian D. Cao-Dao and Ukpong B. Eyo
    Citation: Journal of Neuroinflammation 2023 20:242
  46. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Impaired autophagy in plaque-associated microglia (PAM) has been reported to accelerate amyloid plaque deposition and cognitive impair...

    Authors: Xueting Wang, Yuqi Xie, Guijuan Chen, Yapeng Lu, Dan Wang and Li Zhu
    Citation: Journal of Neuroinflammation 2023 20:240
  47. Inflammasome activation and the subsequent release of pro-inflammatory cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the progression of retinal degenerations, including ...

    Authors: Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man and Riccardo Natoli
    Citation: Journal of Neuroinflammation 2023 20:239

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