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  1. The hypothalamus is a brain structure that is deputed to maintain organism homeostasis by regulating autonomic function and hormonal production as part of the neuroendocrine system. Dysfunction in hypothalamic...

    Authors: Jonathan J. Carver, Kristy M. Lau, Alexandra E. Puckett and Alessandro Didonna
    Citation: Journal of Neuroinflammation 2024 21:12
  2. The tetracycline transactivator (tTA) system provides controllable transgene expression through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment for transgene control in m...

    Authors: Emily J. Koller, Caleb A. Wood, Zoe Lai, Ella Borgenheimer, Kristi L. Hoffman and Joanna L. Jankowsky
    Citation: Journal of Neuroinflammation 2024 21:11
  3. Sepsis is a life-threatening state that arises due to a hyperactive inflammatory response stimulated by infection and rarely other insults (e.g., non-infections tissue injury). Although changes in several proi...

    Authors: Kimberly C. Olney, Camila de Ávila, Kennedi T. Todd, Lauren E. Tallant, J. Hudson Barnett, Katelin A. Gibson, Piyush Hota, Adithya Shyamala Pandiane, Pinar Cay Durgun, Michael Serhan, Ran Wang, Mary Laura Lind, Erica Forzani, Naomi M. Gades, Leslie F. Thomas and John D. Fryer
    Citation: Journal of Neuroinflammation 2024 21:9
  4. Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new...

    Authors: Agata Matejuk, Gil Benedek, Richard Bucala, Szymon Matejuk, Halina Offner and Arthur A. Vandenbark
    Citation: Journal of Neuroinflammation 2024 21:8
  5. Widescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic sta...

    Authors: Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie, Sarah R. Ball, Margaret Sunde, G. Gregory Neely, Cesar L. Moreno, Alexandra Maximova, Eryn L. Werry and Michael Kassiou
    Citation: Journal of Neuroinflammation 2024 21:7
  6. A key pathological factor of Alzheimer’s disease (AD), the most prevalent form of age-related dementia in the world, is excessive β-amyloid protein (Aβ) in extracellular aggregation in the brain. And in the pe...

    Authors: Mingchao Shi, Fengna Chu, Feiqi Zhu and Jie Zhu
    Citation: Journal of Neuroinflammation 2024 21:5
  7. Redox imbalance and inflammation have been proposed as the principal mechanisms of damage in the auditory system, resulting in functional alterations and hearing loss. Microglia and astrocytes play a crucial r...

    Authors: Fabiola Paciello, Anna Pisani, Rolando Rolesi, Raffaele Montuoro, Veronica Mohamed-Hizam, Giammarco Boni, Cristian Ripoli, Jacopo Galli, Renata Sisto, Anna Rita Fetoni and Claudio Grassi
    Citation: Journal of Neuroinflammation 2024 21:4
  8. The involvement of the autonomic nervous system in the regulation of inflammation is an emerging concept with significant potential for clinical applications. Recent studies demonstrate that stimulating the va...

    Authors: Kasey R. Keever, Kui Cui, Jared L. Casteel, Sanjay Singh, Donald B. Hoover, David L. Williams, Valentin A. Pavlov and Valentin P. Yakubenko
    Citation: Journal of Neuroinflammation 2024 21:3
  9. Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence rates and severity of progression. The cellular and molecular mechanisms...

    Authors: Deng Wu, Xiaoman Bi and Kim Hei-Man Chow
    Citation: Journal of Neuroinflammation 2024 21:1
  10. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system that involves B-cell receptor signaling as well as astrocyte–microglia interaction, which both...

    Authors: Ye Liu, Zhenning Huang, Tian-Xiang Zhang, Bin Han, Guili Yang, Dongmei Jia, Li Yang, Qiang Liu, Alexander Y. L. Lau, Friedemann Paul, Alexei Verkhratsky, Fu-Dong Shi and Chao Zhang
    Citation: Journal of Neuroinflammation 2023 20:309
  11. Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophage...

    Authors: Tianyi Shen, Ruoyi Lin, Chengyu Hu, Donghui Yu, Chengda Ren, Tingting Li, Meijiang Zhu, Zhongqi Wan, Tu Su, Yan Wu, Wenting Cai and Jing Yu
    Citation: Journal of Neuroinflammation 2023 20:308
  12. Reinstating inflammation resolution represents an innovative concept to regain inflammation control in diseases marked by chronic inflammation. While most therapeutics target inflammatory molecules and inflamm...

    Authors: Thierry Gauthier, Omayra Martin-Rodriguez, Cécile Chagué, Anna Daoui, Adam Ceroi, Alexis Varin, Francis Bonnefoy, Séverine Valmary-Degano, Mélanie Couturier, Susanne Behlke, Philippe Saas, Pierre-François Cartron and Sylvain Perruche
    Citation: Journal of Neuroinflammation 2023 20:307
  13. Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the brain, behavioral chang...

    Authors: Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Sonja J. Stutz, Aditi…
    Citation: Journal of Neuroinflammation 2023 20:306
  14. Cognitive impairment is associated with dysregulated immune responses. Emerging evidence indicates that Th17 cells and their characteristic cytokine-IL-17 are receiving growing interest in the pathogenesis of ...

    Authors: Tao Wang, Wenjing Feng, Mengwei Ju, Huiyan Yu, Zhiting Guo, Xuejing Sun, Kexin Yang, Miao Liu and Rong Xiao
    Citation: Journal of Neuroinflammation 2023 20:305
  15. Inflammasomes in astrocytes have been shown to play a crucial role in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Cannabinoid Receptor 2(CB2R),...

    Authors: Hong Zhu, Feng Xiao, Yao Xiao, Yun Guo, Xuesong Shan, Zhe Zhang, Lieliang Zhang and Hua Guo
    Citation: Journal of Neuroinflammation 2023 20:304
  16. Acute hyperbaric O2 (HBO) therapy after spinal cord injury (SCI) can reduce inflammation and increase neuronal survival. To our knowledge, it is unknown if these benefits of HBO require hyperbaric vs. normobaric ...

    Authors: Michael D. Sunshine, Victoria E. Bindi, Branden L. Nguyen, Vivian Doerr, Franccesco P. Boeno, Vijayendran Chandran, Ashley J. Smuder and David D. Fuller
    Citation: Journal of Neuroinflammation 2023 20:303
  17. G protein-coupled receptor 120 (GPR120, Ffar4) is a sensor for long-chain fatty acids including omega-3 polyunsaturated fatty acids (n-3 PUFAs) known for beneficial effects on inflammation, metabolism, and moo...

    Authors: Shingo Nakajima, Geneviève Demers, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Khalil Bouyakdan, Alexandre Fisette, Anita Kabahizi, Josephine Robb, Demetra Rodaros, Cyril Laurent, Guillaume Ferreira, Nathalie Arbour, Thierry Alquier and Stephanie Fulton
    Citation: Journal of Neuroinflammation 2023 20:302
  18. Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the relationship between these processes remains elusive. In the curren...

    Authors: Rebecca I. Sienel, Uta Mamrak, Janina Biller, Stefan Roth, Andreas Zellner, Tipparat Parakaw, Rayomand S. Khambata, Arthur Liesz, Christof Haffner, Amrita Ahluwalia, Burcu F. Seker and Nikolaus Plesnila
    Citation: Journal of Neuroinflammation 2023 20:301
  19. Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as well as the b...

    Authors: Samreen N. Shaikh, Emily F. Willis, Max Dierich, Yi Xu, Samuel J. S. Stuart, Glenda C. Gobe, Abate A. Bashaw, Oliver Rawashdeh, Seung Jae Kim and Jana Vukovic
    Citation: Journal of Neuroinflammation 2023 20:300
  20. The neurological effects of the coronavirus disease of 2019 (COVID-19) raise concerns about potential long-term consequences, such as an increased risk of Alzheimer's disease (AD). Neuroinflammation and other ...

    Authors: Muhammad Ali Shahbaz, Suvi Kuivanen, Riikka Lampinen, Laura Mussalo, Tomáš Hron, Táňa Závodná, Ravi Ojha, Zdeněk Krejčík, Liudmila Saveleva, Numan Ahmad Tahir, Juho Kalapudas, Anne M. Koivisto, Elina Penttilä, Heikki Löppönen, Prateek Singh, Jan Topinka…
    Citation: Journal of Neuroinflammation 2023 20:299
  21. Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal clin...

    Authors: Kaja Nordengen, Bjørn-Eivind Kirsebom, Grit Richter, Lene Pålhaugen, Berglind Gísladóttir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Bråthen, Gøril Rolfseng Grøntvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M. Vromen, Betty M. Tijms…
    Citation: Journal of Neuroinflammation 2023 20:298
  22. Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating robust antiinflammatory activity. ...

    Authors: Gunel Ayyubova, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Yogish Somayaji, Bing Shuai, Shama Rao, Goutham Shankar and Ashok K. Shetty
    Citation: Journal of Neuroinflammation 2023 20:297
  23. Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulat...

    Authors: Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2023 20:296
  24. The role of high mobility group box 1 (HMGB1) in inflammation is well characterized in the immune system and in response to tissue injury. More recently, HMGB1 was also shown to initiate an “inflammatory signa...

    Authors: Zeynep Kaya, Nevin Belder, Melike Sever-Bahcekapili, Buket Donmez-Demir, Şefik Evren Erdener, Naz Bozbeyoglu, Canan Bagci, Emine Eren-Kocak, Muge Yemisci, Hulya Karatas, Esra Erdemli, Ihsan Gursel and Turgay Dalkara
    Citation: Journal of Neuroinflammation 2023 20:295
  25. Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studies have focused on the role of skull bone marrow in central nervous system disorders. I...

    Authors: Chaoran Xu, Qia Zhang, Yi Zhang, Huaijun Chen, Tianchi Tang, Junjie Wang, Siqi Xia, Gao Chen and Jianmin Zhang
    Citation: Journal of Neuroinflammation 2023 20:294
  26. Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicated in the pathophysiology of depression. Neuroinflammation-induced hypothalamic dysfunc...

    Authors: Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao and Yu Wu
    Citation: Journal of Neuroinflammation 2023 20:293
  27. Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system xC (SxC) cystine-glutamate antiporter. With the aim of mitigating this source ...

    Authors: Mariusz P. Gajewski and Steven W. Barger
    Citation: Journal of Neuroinflammation 2023 20:292
  28. Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific target...

    Authors: Mathangi Janakiraman, Alexei Leliavski, Jeeva Varadarajulu, Dieter Jenne and Gurumoorthy Krishnamoorthy
    Citation: Journal of Neuroinflammation 2023 20:291
  29. Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a secreted astrocytic glycoprotein that serves as a diagnostic bio...

    Authors: Xiaoyan Zeng, Stanley K. K. Cheung, Mengqi Shi, Penelope M. Y. Or, Zhining Li, Julia Y. H. Liu, Wayne L. H. Ho, Tian Liu, Kun Lu, John A. Rudd, Yubing Wang and Andrew M. Chan
    Citation: Journal of Neuroinflammation 2023 20:290
  30. Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and is associated with poor outcome in the early phase of se...

    Authors: Nils Mein, Nikolai von Stackelberg, Jonathan Wickel, Christian Geis and Ha-Yeun Chung
    Citation: Journal of Neuroinflammation 2023 20:289
  31. Authors: Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan and Adam D. Bachstetter
    Citation: Journal of Neuroinflammation 2023 20:287

    The original article was published in Journal of Neuroinflammation 2023 20:248

  32. Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lyso...

    Authors: Drew A. Gillett, Rebecca L. Wallings, Oihane Uriarte Huarte and Malú Gámez Tansey
    Citation: Journal of Neuroinflammation 2023 20:286
  33. Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention an...

    Authors: Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu and Yanni Lv
    Citation: Journal of Neuroinflammation 2023 20:285
  34. Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). It has been reported that TRIM45 is associated with tumours and inflammatory diseases. H...

    Authors: Xuliang Huang, Changzhou Ye, Xinyu Zhao, Yao Tong, Wen Lin, Qingqing Huang, Yuhao Zheng, Junlu Wang, Anqi Zhang and Yunchang Mo
    Citation: Journal of Neuroinflammation 2023 20:284
  35. The gut microbiota has recently attracted attention as a pathogenic factor in Alzheimer’s disease (AD). Microfold (M) cells, which play a crucial role in the gut immune response against external antigens, are ...

    Authors: Namkwon Kim, In Gyoung Ju, Seung Ho Jeon, Yeongae Lee, Min-Ji Jung, Min Sung Gee, Jae Seok Cho, Kyung-Soo Inn, Lee Ann Garrett-Sinha, Myung Sook Oh and Jong Kil Lee
    Citation: Journal of Neuroinflammation 2023 20:282
  36. Inflammatory response triggered by innate immunity plays a pivotal element in the progress of ischemic stroke. Receptor-interacting kinase 2 (RIP2) is implicated in maintaining immunity homeostasis and regulat...

    Authors: Shengnan Zheng, Yiquan Li, Xiaomeng Song, Mengting Wu, Lu Yu, Gan Huang, Tengfei Liu, Lei Zhang, Mingmei Shang, Qingfen Zhu, Chengjiang Gao, Lin Chen and Huiqing Liu
    Citation: Journal of Neuroinflammation 2023 20:281
  37. Neonatal encephalopathy following hypoxia–ischemia (HI) is a leading cause of childhood death and morbidity. Hypothermia (HT), the only available but obligatory therapy is limited due to a short therapeutic wi...

    Authors: Nicole Labusek, Parnian Ghari, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Martin Hadamitzky, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel and Josephine Herz
    Citation: Journal of Neuroinflammation 2023 20:280
  38. Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascularization (CNV), and AMD is the leading cause of irreversible vision impairment in older ...

    Authors: Yu-Hsien Chang, Chung-Hsi Hsing, Chiao-Juno Chiu, Yi-Rou Wu, Sheng-Min Hsu and Yu-Hsiang Hsu
    Citation: Journal of Neuroinflammation 2023 20:279
  39. Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer’s disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accum...

    Authors: Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari…
    Citation: Journal of Neuroinflammation 2023 20:278
  40. Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation i...

    Authors: Wei Bi, Keyao Bao, Xinqi Zhou, Yihui Deng, Xiaoting Li, Jiawei Zhang, Xin Lan, Jiayi Zhao, Daxiang Lu, Yezi Xu, Yanmei Cen, Rui Cao, Mengyang Xu, Wenbin Zhong and Lihong Zhu
    Citation: Journal of Neuroinflammation 2023 20:277
  41. Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodegenerative disorders, including Huntington’s disease (HD). HD is a genetic condition caus...

    Authors: Noam Steinberg, Danny Galleguillos, Asifa Zaidi, Melanie Horkey and Simonetta Sipione
    Citation: Journal of Neuroinflammation 2023 20:276
  42. Regulatory T cells (Tregs) are involved in the systemic immune response after ischemic stroke. However, their role remains unclear, and the effect appears to be both neuroprotective and detrimental. Treg suppr...

    Authors: Maria Lukasik, Magdalena Telec, Radoslaw Kazmierski, Izabela Wojtasz, Natalia Andrzejewska-Gorczyńska, Wojciech Kociemba, Grzegorz Dworacki, Wojciech P. Kozubski and Magdalena Frydrychowicz
    Citation: Journal of Neuroinflammation 2023 20:275
  43. Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered a potential susceptibility gene for Parkinson’s disease (PD), and has been demonstrated to possess protective effects ...

    Authors: Tianbai Li, Xiang Tan, Lulu Tian, Congcong Jia, Cheng Cheng, Xi Chen, Min Wei, Yuanyuan Wang, Yiying Hu, Qiqi Jia, Yang Ni, Murad Al-Nusaif, Song Li and Weidong Le
    Citation: Journal of Neuroinflammation 2023 20:274
  44. Traumatic spinal cord injury can cause immediate physical damage to the spinal cord and result in severe neurological deficits. The primary, mechanical tissue damage triggers a variety of secondary damage mech...

    Authors: Marie-Kim St-Pierre, Fernando González Ibáñez, Antje Kroner and Marie-Ève Tremblay
    Citation: Journal of Neuroinflammation 2023 20:273
  45. Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer’s disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer’s disease. TREM2 i...

    Authors: Oliver Cousins, Julia J. Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O’Neill, David Collier…
    Citation: Journal of Neuroinflammation 2023 20:272
  46. Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-inflammatory, and antitumor properties. However, as the effects of C3G on the amyloidogenic pathway, autophagy, tau phosphorylation,...

    Authors: Hana Baek, Sanjay, Miey Park and Hae-Jeung Lee
    Citation: Journal of Neuroinflammation 2023 20:268

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