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  1. Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1−/− mice display alterations in non-classical monocytes and microgli...

    Authors: Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine
    Citation: Journal of Neuroinflammation 2023 20:238
  2. Glucose transporter 1 (GLUT1) is essential for glucose transport into the brain and is predominantly expressed in the cerebral microvasculature. Downregulation of GLUT1 precedes the development of cognitive im...

    Authors: Ying Chen, Jin Joo, John Man-Tak Chu, Raymond Chuen-Chung Chang and Gordon Tin-Chun Wong
    Citation: Journal of Neuroinflammation 2023 20:237
  3. The noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of neurostimulation therapies for inflammatory diseases. However, there is no real-tim...

    Authors: Ibrahim T. Mughrabi, Michael Gerber, Naveen Jayaprakash, Santhoshi P. Palandira, Yousef Al-Abed, Timir Datta-Chaudhuri, Corey Smith, Valentin A. Pavlov and Stavros Zanos
    Citation: Journal of Neuroinflammation 2023 20:236
  4. Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer’s disease (AD). The bas...

    Authors: Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Münch, Yossi Buskila and Erika Gyengesi
    Citation: Journal of Neuroinflammation 2023 20:235
  5. Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). Infiltrating inflammatory immune cells perpetuate demyelination and axonal damage in the CNS and si...

    Authors: Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock, Arshiya Mariam, Maria L. Habean, Ranjan Dutta and Jessica L. Williams
    Citation: Journal of Neuroinflammation 2023 20:234
  6. The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is a...

    Authors: Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez and Maria Dolores Ganfornina
    Citation: Journal of Neuroinflammation 2023 20:233
  7. Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury. Chronically after stroke, repair processes, including an...

    Authors: Justin N. Nguyen, Eric C. Mohan, Gargee Pandya, Uzma Ali, Chunfeng Tan, Julia K. Kofler, Linda Shapiro, Sean P. Marrelli and Anjali Chauhan
    Citation: Journal of Neuroinflammation 2023 20:232
  8. Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central ner...

    Authors: Nina Stöberl, Emily Maguire, Elisa Salis, Bethany Shaw and Hazel Hall-Roberts
    Citation: Journal of Neuroinflammation 2023 20:231
  9. Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injur...

    Authors: Maria P. Blasco Conesa, Frank W. Blixt, Pedram Peesh, Romeesa Khan, Janelle Korf, Juneyoung Lee, Gayathri Jagadeesan, Alexander Andersohn, Tushar K. Das, Chunfeng Tan, Claudia Di Gesu, Gabriela Delevati Colpo, Jose Félix Moruno-Manchón, Louise D. McCullough, Robert Bryan and Bhanu P. Ganesh
    Citation: Journal of Neuroinflammation 2023 20:230
  10. Multiple sclerosis (MS) has traditionally been viewed as a chronic inflammatory disease affecting the white matter of the central nervous system. However, over the past two decades, increasing evidence has hig...

    Authors: Kanak Gupta, Ajay Kesharwani, Steven Rua, Saumitra Sen Singh, Catherine Siu, Larissa Jank, Matthew D. Smith, Peter A. Calabresi and Pavan Bhargava
    Citation: Journal of Neuroinflammation 2023 20:229
  11. Periodontitis-related oral microbial dysbiosis is thought to contribute to Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics can modulate periodontitis/oral dysbiosis, t...

    Authors: Chuanjiang Zhao, Ryutaro Kuraji, Changchang Ye, Li Gao, Allan Radaic, Pachiyappan Kamarajan, Yoshimasa Taketani and Yvonne L. Kapila
    Citation: Journal of Neuroinflammation 2023 20:228
  12. Some patients show persistent cognitive decline for weeks, months or even years after surgery, which seriously affects their long-term prognosis and quality of life. However, most previous basic studies have f...

    Authors: Xiaowei Li, Hong Wang, Qidi Zhang, Xiaobin Sun, Mengyuan Zhang and Gongming Wang
    Citation: Journal of Neuroinflammation 2023 20:227
  13. Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain endothelium dysfunction is a hallmark of BBB breakd...

    Authors: Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque and Elena González-Rey
    Citation: Journal of Neuroinflammation 2023 20:226
  14. Neuromyelitis optica spectrum disorder (NMOSD) stands out among CNS inflammatory demyelinating diseases (CIDDs) due to its unique disease characteristics, including severe clinical attacks with extensive lesio...

    Authors: Hyo Jae Kim, Jong-Eun Park, Wangyong Shin, Dayoung Seo, Seungmi Kim, Hyunji Kim, Jinsung Noh, Yonghee Lee, Hyunjin Kim, Young-Min Lim, Hyori Kim and Eun-Jae Lee
    Citation: Journal of Neuroinflammation 2023 20:225
  15. The inflammatory response to cerebral ischemia is complex; however, most clinical studies of stroke outcome focus on a few selected proteins. We, therefore, aimed to profile a broad range of inflammation-relat...

    Authors: Annelie Angerfors, Cecilia Brännmark, Cecilia Lagging, Kara Tai, Robert Månsby Svedberg, Björn Andersson, Christina Jern and Tara M. Stanne
    Citation: Journal of Neuroinflammation 2023 20:224
  16. Microglia are so versatile that they not only provide immune surveillance for central nervous system, but participate in neural circuitry development, brain blood vessels formation, blood–brain barrier archite...

    Authors: Hongrui Zhu, Ao Guan, Jiayuan Liu, Li Peng, Zhi Zhang and Sheng Wang
    Citation: Journal of Neuroinflammation 2023 20:223
  17. Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming neutrophils were found throughout the bra...

    Authors: Guihong Shi, Liang Liu, Yiyao Cao, Guangshuo Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Liang Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu…
    Citation: Journal of Neuroinflammation 2023 20:222
  18. Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signaling through its association with pattern recognition receptors (PRRs) and subsequent TAK1...

    Authors: Jonathan Larochelle, Ryland J. Tishko, Changjun Yang, Yong Ge, Leah T. Phan, Rachel E. Gunraj, Sofia M. Stansbury, Lei Liu, Mansour Mohamadzadeh, Habibeh Khoshbouei and Eduardo Candelario-Jalil
    Citation: Journal of Neuroinflammation 2023 20:221
  19. To explore the association of systemic inflammatory index (SIRI), systemic immune-inflammatory index (SII) and inflammatory prognosis index (IPI) with 90d outcomes in patients with acute ischemic stroke (AIS) ...

    Authors: Fei Ma, Lulu Li, Liang Xu, Jiacheng Wu, Aimei Zhang, Junqi Liao, Jingyi Chen, Yunze Li, Li Li, Zhaoyao Chen, Wenlei Li, Qing Zhu, Yuan Zhu and Minghua Wu
    Citation: Journal of Neuroinflammation 2023 20:220
  20. Spinal cord injury (SCI), which causes loss of sensory and motor function in the body below the level of injury, is a devastating disease of the central nervous system. SCI leads to severe secondary immunosupp...

    Authors: Hong Zeng, Li Cheng, De-zhi Lu, Shuai Fan, Ke-xin Wang, Li-li Xu, Bin Cai, Mou-wang Zhou and Jin-wu Wang
    Citation: Journal of Neuroinflammation 2023 20:219
  21. Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections, that can lead to serious metabolic consequences and even death...

    Authors: Marta Dobrzyńska, Anna Moniuszko-Malinowska and Elżbieta Skrzydlewska
    Citation: Journal of Neuroinflammation 2023 20:218
  22. Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeutic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infecti...

    Authors: Patricia Mingo-Casas, Ana-Belén Blázquez, Marta Gómez de Cedrón, Ana San-Félix, Susana Molina, Estela Escribano-Romero, Eva Calvo-Pinilla, Nereida Jiménez de Oya, Ana Ramírez de Molina, Juan-Carlos Saiz, María-Jesús Pérez-Pérez and Miguel A. Martín-Acebes
    Citation: Journal of Neuroinflammation 2023 20:217
  23. Japanese encephalitis virus (JEV) remains a predominant cause of Japanese encephalitis (JE) globally. Its infection is usually accompanied by disrupted blood‒brain barrier (BBB) integrity and central nervous s...

    Authors: Ya-Ge Zhang, Hong-Xin Zhang, Hao-Wei Chen, Penghao Lv, Jie Su, Yan-Ru Chen, Zhen-Fang Fu and Min Cui
    Citation: Journal of Neuroinflammation 2023 20:216
  24. Recent studies suggest that extended interval dosing of ocrelizumab, an anti-B cell therapy, does not affect its clinical effectiveness in most patients with multiple sclerosis (MS). However, it remains to be ...

    Authors: Carla Rodriguez-Mogeda, Zoë Y. G. J. van Lierop, Susanne M. A. van der Pol, Loet Coenen, Laura Hogenboom, Alwin Kamermans, Ernesto Rodriguez, Jack van Horssen, Zoé L. E. van Kempen, Bernard M. J. Uitdehaag, Charlotte E. Teunissen, Maarten E. Witte, Joep Killestein and Helga E. de Vries
    Citation: Journal of Neuroinflammation 2023 20:215
  25. Studies of microglial gene manipulation in mouse models of Alzheimer’s disease (AD) amyloidopathy can cause unpredictable effects on various key endpoints, including amyloidosis, inflammation, neuritic dystrop...

    Authors: Sam Gandy and Michelle E. Ehrlich
    Citation: Journal of Neuroinflammation 2023 20:214

    The Correction to this article has been published in Journal of Neuroinflammation 2023 20:288

  26. Type I interferons (IFN-I) are fundamental in controlling viral infections but fatal interferonopathy is restricted in the immune-privileged central nervous system (CNS). In contrast to the well-established ro...

    Authors: Loreen Weichert, Henning Peter Düsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay and Andrea Kröger
    Citation: Journal of Neuroinflammation 2023 20:213
  27. Neuronal iron overload contributes to synaptic damage and neuropsychiatric disorders. However, the molecular mechanisms underlying iron deposition in depression remain largely unexplored. Our study aims to inv...

    Authors: Ting Zeng, Junjie Li, Lingpeng Xie, Zhaoyang Dong, Qing Chen, Sha Huang, Shuwen Xie, Yuqi Lai, Jun Li, Weixin Yan, YuHua Wang, Zeping Xie, Changlei Hu, Jiayi Zhang, Shanshan Kuang, Yuhong Song…
    Citation: Journal of Neuroinflammation 2023 20:212
  28. The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years. Additionally, inhibition of various components of the c...

    Authors: Tiffany J. Petrisko, Matthew Gargus, Shu-Hui Chu, Purnika Selvan, Katrine L. Whiteson and Andrea J. Tenner
    Citation: Journal of Neuroinflammation 2023 20:211
  29. The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. Howev...

    Authors: Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner and Dirk M. Hermann
    Citation: Journal of Neuroinflammation 2023 20:210
  30. In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blocka...

    Authors: Michael Sy, Barbara L. Newton, Judy Pawling, Ken L. Hayama, Andres Cordon, Zhaoxia Yu, Jens Kuhle, James W. Dennis, Alexander U. Brandt and Michael Demetriou
    Citation: Journal of Neuroinflammation 2023 20:209
  31. Cellular senescence serves as a fundamental and underlying activity that drives the aging process, and it is intricately associated with numerous age-related diseases, including Alzheimer's disease (AD), a neu...

    Authors: Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding and Aiqing Yu
    Citation: Journal of Neuroinflammation 2023 20:208
  32. Vascular endothelial function is challenged during cerebral ischemia and reperfusion. The endothelial responses are involved in inflammatory leukocyte attraction, adhesion and infiltration, blood–brain barrier...

    Authors: Maria Arbaizar-Rovirosa, Mattia Gallizioli, Juan J. Lozano, Julia Sidorova, Jordi Pedragosa, Sara Figuerola, Nerea Chaparro-Cabanillas, Patricia Boya, Mariona Graupera, Marc Claret, Xabier Urra and Anna M. Planas
    Citation: Journal of Neuroinflammation 2023 20:207
  33. Retinal degeneration is a disease affecting the eye, which is an immune-privileged site because of its anatomical and physiological properties. Alterations in retinal homeostasis—because of injury, disease, or...

    Authors: Federica M. Conedera, Judith M. Runnels, Jens V. Stein, Clemens Alt, Volker Enzmann and Charles P. Lin
    Citation: Journal of Neuroinflammation 2023 20:206
  34. Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’...

    Authors: Naga Venkata Divya Challa, Shaoyi Chen, Huijun Yuan, Matthew R. Duncan, William Javier Moreno, Helen Bramlett, W. Dalton Dietrich, Merline Benny, Augusto F. Schmidt, Karen Young and Shu Wu
    Citation: Journal of Neuroinflammation 2023 20:205
  35. 17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) is based on the physiological dose of E2 to treat menopausal syndro...

    Authors: Ming Li, Jing Zhang, Wendi Chen, Shuang Liu, Xin Liu, Yunna Ning, Yongzhi Cao and Yueran Zhao
    Citation: Journal of Neuroinflammation 2023 20:204
  36. Astrocytes contribute to chronic neuroinflammation in a variety of neurodegenerative diseases, including Parkinson's disease (PD), the most common movement disorder. However, the precise role of astrocytes in ...

    Authors: Shu Yin, Xin-yue Ma, Ying-feng Sun, Yan-qing Yin, Ying Long, Chun-lai Zhao, Jun-wei Ma, Sen Li, Yan Hu, Ming-tao Li, Gang Hu and Jia-wei Zhou
    Citation: Journal of Neuroinflammation 2023 20:203
  37. Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers retinal ganglion cells (RGCs) change and synapse loss. Microglia is the resistant immune cell in brain and retina and has been dem...

    Authors: Ke Yao, Qianxue Mou, Xiaotong Lou, Meng Ye, Bowen Zhao, Yuanyuan Hu, Jing Luo, Hong Zhang, Xing Li and Yin Zhao
    Citation: Journal of Neuroinflammation 2023 20:202
  38. Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke or traumatic brain injury. Our previous work showed that mese...

    Authors: Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore and Maria Medalla
    Citation: Journal of Neuroinflammation 2023 20:201
  39. Peripheral nerve injury to dorsal root ganglion (DRG) neurons develops intractable neuropathic pain via induction of neuroinflammation. However, neuropathic pain is rare in the early life of rodents. Here, we ...

    Authors: Yuka Ino, Motoyo Maruyama, Masumi Shimizu, Rimpei Morita, Atsuhiro Sakamoto, Hidenori Suzuki and Atsushi Sakai
    Citation: Journal of Neuroinflammation 2023 20:200
  40. Epidemiological data suggests statins could reduce the risk of dementia, and more specifically, Alzheimer’s disease (AD). Pre-clinical data suggests statins reduce the risk of dementia through their pleiotropi...

    Authors: Erica M. Weekman, Sherika N. Johnson, Colin B. Rogers, Tiffany L. Sudduth, Kevin Xie, Qi Qiao, David W. Fardo, Teodoro Bottiglieri and Donna M. Wilcock
    Citation: Journal of Neuroinflammation 2023 20:199
  41. Most current disease-modifying therapies approved for multiple sclerosis (MS) are immunomodulatory drugs that counteract the aberrant activity of the immune system. Hence, new pharmacological interventions tha...

    Authors: Alejandro Torrillas-de la Cal, Sonia Torres-Sanchez, Lidia Bravo, Meritxell Llorca-Torralba, Jose Antonio Garcia-Partida, Ana I. Arroba and Esther Berrocoso
    Citation: Journal of Neuroinflammation 2023 20:198
  42. Medical advances have made it increasingly possible for spinal cord injury (SCI) survivors to survive decades after the insult. But how SCI affects aging changes and aging impacts the injury process have recei...

    Authors: Yun Li, Niaz Khan, Rodney M. Ritzel, Zhuofan Lei, Samantha Allen, Alan I. Faden and Junfang Wu
    Citation: Journal of Neuroinflammation 2023 20:197
  43. Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite extensive studies investigating the underlying mechanisms of mTBI-assoc...

    Authors: Tyler Nguyen, Natalie Nguyen, Ashlyn G. Cochran, Jared A. Smith, Mohammed Al-Juboori, Andrew Brumett, Saahil Saxena, Sarah Talley, Edward M. Campbell, Alexander G. Obukhov and Fletcher A. White
    Citation: Journal of Neuroinflammation 2023 20:196
  44. Cortical superficial siderosis (cSS) has recently emerged as one of the most important predictors of symptomatic intracerebral hemorrhage and is a risk factor for post-stroke dementia in cerebral amyloid angio...

    Authors: Corinne A. Auger, Valentina Perosa, Steven M. Greenberg, Susanne J. van Veluw and Mariel G. Kozberg
    Citation: Journal of Neuroinflammation 2023 20:195
  45. Bruton’s tyrosine kinase (BTK) is a key signaling node in B cell receptor (BCR) and Fc receptor (FcR) signaling. BTK inhibitors (BTKi) are an emerging oral treatment option for patients suffering from multiple...

    Authors: Barbara Nuesslein-Hildesheim, Enrico Ferrero, Cindy Schmid, Catherine Huck, Paul Smith, Sarah Tisserand, Joelle Rubert, Frederic Bornancin, Denis Eichlisberger and Bruno Cenni
    Citation: Journal of Neuroinflammation 2023 20:194
  46. Temporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic activity of microglia is essential for clearing apoptotic neuronal debris, allowing for...

    Authors: Xiaoxia Yang, Qingqing Cao, Yi Guo, Jingchuan He, Demei Xu and Aolei Lin
    Citation: Journal of Neuroinflammation 2023 20:193
  47. Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phe...

    Authors: David Scieszka, Yan Jin, Shahani Noor, Ed Barr, Marcus Garcia, Jessica Begay, Guy Herbert, Russell P. Hunter, Kiran Bhaskar, Rahul Kumar, Rama Gullapalli, Alicia Bolt, Mark A. McCormick, Barry Bleske, Haiwei Gu and Matthew J. Campen
    Citation: Journal of Neuroinflammation 2023 20:192
  48. Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and diminished interest. Although many clinical and animal studies have provided significant ins...

    Authors: Huanhuan Li, Anni Guo, Magdiel Salgado, Juan C. Sáez and Chunyue Geoffrey Lau
    Citation: Journal of Neuroinflammation 2023 20:191
  49. Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause changes to cognition and behavior. Similarly, peripheral infection by non...

    Authors: Allison Y. Louie, Justin S. Kim, Jenny Drnevich, Payam Dibaeinia, Hisami Koito, Saurabh Sinha, Daniel B. McKim, Katiria Soto-Diaz, Romana A. Nowak, Aditi Das and Andrew J. Steelman
    Citation: Journal of Neuroinflammation 2023 20:190
  50. A sports-related concussion (SRC) is often caused by rapid head rotation at impact, leading to shearing and stretching of axons in the white matter and initiation of secondary inflammatory processes that may e...

    Authors: Anna Gard, Fredrik Vedung, Fredrik Piehl, Mohsen Khademi, Maria Portonova Wernersson, Ia Rorsman, Yelverton Tegner, Hélène Pessah-Rasmussen, Karsten Ruscher and Niklas Marklund
    Citation: Journal of Neuroinflammation 2023 20:189

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