Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128.
Article
PubMed
Google Scholar
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D. Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study. Lancet Infect Dis. 2016;16(3):339–47.
Article
PubMed
Google Scholar
Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev. 2010;23(3):467–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351(18):1849–59.
Article
PubMed
Google Scholar
van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N Engl J Med. 2006;354(1):44–53.
Article
PubMed
Google Scholar
Hoogman M, van de Beek D, Weisfelt M, de Gans J, Schmand B. Cognitive outcome in adults after bacterial meningitis. J Neurol Neurosurg Psychiatry. 2007;78(10):1092–6.
Article
PubMed
PubMed Central
Google Scholar
Brouwer MC, de Gans J, Heckenberg SG, Zwinderman AH, van der Poll T, van de Beek D. Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis. 2009;9(1):31–44.
Article
CAS
PubMed
Google Scholar
Kasanmoentalib ES, Brouwer MC, van de Beek D. Update on bacterial meningitis: epidemiology, trials and genetic association studies. Curr Opin Neurol. 2013;26(3):282–8.
Article
PubMed
Google Scholar
Ferwerda B, Valls Seron M, Jongejan A, Zwinderman AH, Geldhoff M, van der Ende A, Baas F, Brouwer MC, van de Beek D. Variation of 46 innate immune genes evaluated for their contribution in pneumococcal meningitis susceptibility and outcome. EBioMedicine. 2016;10:77–84.
Article
PubMed
PubMed Central
Google Scholar
Davila S, Wright VJ, Khor CC, Sim KS, Binder A, Breunis WB, Inwald D, Nadel S, Betts H, Carrol ED, et al. Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet. 2010;42(9):772–6.
Article
CAS
PubMed
Google Scholar
Mook-Kanamori BB, Geldhoff M, van der Poll T, van de Beek D. Pathogenesis and pathophysiology of pneumococcal meningitis. Clin Microbiol Rev. 2011;24(3):557–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Valls Seron M, Ferwerda B, Engelen-Lee J, Geldhoff M, Jaspers V, Zwinderman AH, Tanck MW, Baas F, van der Ende A, Brouwer MC, et al. V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. Acta Neuropathol Commun. 2016;4(1):50.
Article
PubMed
PubMed Central
Google Scholar
Woehrl B, Brouwer MC, Murr C, Heckenberg SG, Baas F, Pfister HW, Zwinderman AH, Morgan BP, Barnum SR, van der Ende A, et al. Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J Clin Invest. 2011;121(10):3943–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Savva A, Brouwer MC, Roger T, Valls Seron M, Le Roy D, Ferwerda B, van der Ende A, Bochud PY, van de Beek D, Calandra T. Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis. Proc Natl Acad Sci U S A. 2016;113(13):3597–602.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brouwer MC, Meijers JC, Baas F, van der Ende A, Pfister HW, Giese A, van de Beek D, Koedel U. Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. Acta Neuropathol. 2014;127(4):553–64.
Article
CAS
PubMed
Google Scholar
Kasanmoentalib ES, Valls Seron M, Morgan BP, Brouwer MC, van de Beek D. Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial. J Neuroinflammation. 2015;12:149.
Article
PubMed
PubMed Central
Google Scholar
Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto M. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A. 2002;99(26):16969–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, et al. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog. 2012;8(7):e1002793.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brouwer MC, Heckenberg SG, de Gans J, Spanjaard L, Reitsma JB, van de Beek D. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. Neurology. 2010;75(17):1533–9.
Article
CAS
PubMed
Google Scholar
Jennett B, Teasdale G, Braakman R, Minderhoud J, Knill-Jones R. Predicting outcome in individual patients after severe head injury. Lancet. 1976;1(7968):1031–4.
Article
CAS
PubMed
Google Scholar
Mook-Kanamori B, Geldhoff M, Troost D, van der Poll T, van de Beek D. Characterization of a pneumococcal meningitis mouse model. BMC Infect Dis. 2012;12:71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, et al. Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2011;108(18):7523–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Adriani KS, Brouwer MC, Geldhoff M, Baas F, Zwinderman AH, Paul Morgan B, Harris CL, van der Ende A, van de Beek D. Common polymorphisms in the complement system and susceptiblity to bacterial meningitis. J Infect. 2013;66(3):255–62.
Article
PubMed
Google Scholar
Mook-Kanamori BB, Brouwer MC, Geldhoff M, Ende A, van de Beek D. Cerebrospinal fluid complement activation in patients with pneumococcal and meningococcal meningitis. J Infect. 2014;68(6):542–7.
Article
PubMed
Google Scholar
Tauber MG, Khayam-Bashi H, Sande MA. Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis. J Infect Dis. 1985;151(3):528–34.
Article
CAS
PubMed
Google Scholar
Rupprecht TA, Angele B, Klein M, Heesemann J, Pfister HW, Botto M, Koedel U. Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system. J Immunol. 2007;178(3):1861–9.
Article
CAS
PubMed
Google Scholar
Kjaer TR, Hansen AG, Sorensen UB, Holm AT, Sorensen GL, Jensenius JC, Thiel S. M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain. Infect Immun. 2013;81(2):452–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krarup A, Sorensen UB, Matsushita M, Jensenius JC, Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect Immun. 2005;73(2):1052–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zwijnenburg PJ, van der Poll T, Florquin S, Polfliet MM, van den Berg TK, Dijkstra CD, Roord JJ, Hack CE, van Furth AM. C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. J Infect Dis. 2007;196(1):115–23.
Article
PubMed
Google Scholar
Brouwer MC, Baas F, van der Ende A, van de Beek D. Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients. PLoS One. 2013;8(5):e65151.
Article
CAS
PubMed
PubMed Central
Google Scholar
Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490(7419):187–91.
Article
CAS
PubMed
PubMed Central
Google Scholar