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  1. Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking. Autoantibodies against sept...

    Authors: Ramona Miske, Madeleine Scharf, Kathrin Borowski, Nicole Rieckhoff, Bianca Teegen, Yvonne Denno, Christian Probst, Kersten Guthke, Ieva Didrihsone, Brigitte Wildemann, Klemens Ruprecht, Lars Komorowski and Sven Jarius
    Citation: Journal of Neuroinflammation 2023 20:88
  2. Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology. Here, we report th...

    Authors: Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang and Hong Cao
    Citation: Journal of Neuroinflammation 2023 20:87
  3. Previous studies have shown a close association between an altered immune system and Parkinson's disease (PD). Neuroinflammation inhibition may be an effective measure to prevent PD. Recently, numerous reports...

    Authors: Dewei He, Shoupeng Fu, Bojian Ye, Hefei Wang, Yuan He, Zhe Li, Jie Li, Xiyu Gao and Dianfeng Liu
    Citation: Journal of Neuroinflammation 2023 20:86
  4. Recent literature on multiple sclerosis (MS) demonstrates the growing implementation of optical coherence tomography–angiography (OCT-A) to discover potential qualitative and quantitative changes in the retina...

    Authors: Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi, J. Fernando Arevalo, Steven L. Galetta, Hamid Harandi, Elliot M. Frohman, Teresa C. Frohman, Shiv Saidha, Neda Sattarnezhad and Friedemann Paul
    Citation: Journal of Neuroinflammation 2023 20:85
  5. Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems. The hypothesis of monoamine neu...

    Authors: Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei and Ling Zhao
    Citation: Journal of Neuroinflammation 2023 20:84
  6. Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the central nervous system (CNS). Although studies have demonstrated that microglia facilitate remyelination in demyelinating diseas...

    Authors: Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang and Jun Wang
    Citation: Journal of Neuroinflammation 2023 20:83
  7. Central post-stroke pain (CPSP) is an intractable and disabling central neuropathic pain that severely affects patients’ lives, well-being, and socialization abilities. However, CPSP has been poorly studied me...

    Authors: Zhong-Mou Shi, Jun-Jie Jing, Zheng-Jie Xue, Wen-Jun Chen, Yan-Bin Tang, Du-Juan Chen, Xin-Yi Qi, Li Huang, Yi-Qing Zou, Xiao-Zhi Wu and Fei Yang
    Citation: Journal of Neuroinflammation 2023 20:82
  8. Long-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior cingulate cortex (ACC) has been demonstrated to be associated with pain and...

    Authors: Dan-dan Long, Yu-zhuo Zhang, An Liu, Liang Shen, Hong-rui Wei, Qian-qian Lou, Shan-shan Hu, Dan-yang Chen, Xiao-qing Chai and Di Wang
    Citation: Journal of Neuroinflammation 2023 20:81
  9. The unique intracranial tumor microenvironment (TME) contributes to the immunotherapy failure for glioblastoma (GBM), thus new functional protein targets are urgently needed. Alternative splicing is a widespre...

    Authors: Bowen Ni, Guanglong Huang, Runwei Yang, Ziyu Wang, Haimin Song, Kaishu Li, Yunxiao Zhang, Kezhi Wu, Guangwei Shi, Xiran Wang, Jie Shen and Yawei Liu
    Citation: Journal of Neuroinflammation 2023 20:80
  10. Neuroinflammation has been suggested as a pathogenetic mechanism contributing to Parkinson’s disease (PD). However, anti-inflammatory treatment strategies have not yet been established as a therapeutic option ...

    Authors: Alexander Grotemeyer, Judith F. Fischer, James B. Koprich, Jonathan M. Brotchie, Robert Blum, Jens Volkmann and Chi Wang Ip
    Citation: Journal of Neuroinflammation 2023 20:79
  11. Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches. We study the major histocompa...

    Authors: Season K. Wyatt-Johnson, Holly N. Kersey, Juan F. Codocedo, Kathy L. Newell, Gary E. Landreth, Bruce T. Lamb, Adrian L. Oblak and Randy R. Brutkiewicz
    Citation: Journal of Neuroinflammation 2023 20:78
  12. Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clin...

    Authors: Brittney R. Lins, Chidozie C. Anyaegbu, Sarah C. Hellewell, Melissa Papini, Terence McGonigle, Luca De Prato, Matthew Shales and Melinda Fitzgerald
    Citation: Journal of Neuroinflammation 2023 20:77
  13. Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study...

    Authors: Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi and Hao Fang
    Citation: Journal of Neuroinflammation 2023 20:75
  14. Naturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as apoptotic and necrotic cells. However, NAbs pathological relevance in Alzh...

    Authors: Dongmei Gu, Luchun Wang, Nan Zhang, Huali Wang and Xin Yu
    Citation: Journal of Neuroinflammation 2023 20:74
  15. The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To provide novel insights into the roles of astrocytes in the pathop...

    Authors: Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent and Marie-Ève Tremblay
    Citation: Journal of Neuroinflammation 2023 20:73
  16. Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its detachment from microtubules and formation of insoluble intracellular aggregates within the neurons. Recent findings have ...

    Authors: Mahima Kapoor and Subashchandrabose Chinnathambi
    Citation: Journal of Neuroinflammation 2023 20:72
  17. Systemic activation of the immune system can exert detrimental effects on the central nervous system. Periodontitis, a chronic disease of the oral cavity, is a common source of systemic inflammation. Neuroinfl...

    Authors: Rachel Pei-Hsuan Wang, Jianpan Huang, Kannie Wai Yan Chan, Wai Keung Leung, Tetsuya Goto, Yuen-Shan Ho and Raymond Chuen-Chung Chang
    Citation: Journal of Neuroinflammation 2023 20:71
  18. Neutrophil serine proteinases (NSPs), released by activated neutrophils, are key proteins involved in the pathophysiologic processes of stroke. NSPs are also implicated in the process and response of thromboly...

    Authors: Lingzhi Li, Ziping Han, Rongliang Wang, Junfen Fan, Yangmin Zheng, Yuyou Huang, Zhenhong Yang, Feng Yan, Ping Liu, Haiping Zhao, Qingfeng Ma and Yumin Luo
    Citation: Journal of Neuroinflammation 2023 20:70
  19. Microglial activation-mediated neuroinflammation is one of the essential pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence suggests that high mobility group box-1 protein (HMGB...

    Authors: Xiao-Yu Yin, Xiao-Hui Tang, Shi-Xu Wang, Yong-Chang Zhao, Min Jia, Jian-Jun Yang, Mu-Huo Ji and Jin-Chun Shen
    Citation: Journal of Neuroinflammation 2023 20:69
  20. Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PE...

    Authors: Anna Ballweg, Carolin Klaus, Letizia Vogler, Sabrina Katzdobler, Karin Wind, Artem Zatcepin, Sibylle I. Ziegler, Birkan Secgin, Florian Eckenweber, Bernd Bohr, Alexander Bernhardt, Urban Fietzek, Boris-Stephan Rauchmann, Sophia Stoecklein, Stefanie Quach, Leonie Beyer…
    Citation: Journal of Neuroinflammation 2023 20:68
  21. Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with over 2.8 million affected annually in the U.S., including over 56,000 deaths, with over 5 million total survivors exh...

    Authors: Michael R. Grovola, Catherine von Reyn, David J. Loane and D. Kacy Cullen
    Citation: Journal of Neuroinflammation 2023 20:67
  22. Helicobacter pylori (Hp) infects the stomach of 50% of the world’s population. Importantly, chronic infection by this bacterium correlates with the appearance of several extra-gastric pathologies, including neuro...

    Authors: Esteban Palacios, Lorena Lobos-González, Simón Guerrero, Marcelo J. Kogan, Baohai Shao, Jay W. Heinecke, Andrew F. G. Quest, Lisette Leyton and Manuel Valenzuela-Valderrama
    Citation: Journal of Neuroinflammation 2023 20:66
  23. Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD). However, the association between peripheral inflammatory factors and brain neurodegeneration is poorly understood...

    Authors: Min Chu, Lulu Wen, Deming Jiang, Li Liu, Haitian Nan, Ailing Yue, Yingtao Wang, Yihao Wang, Miao Qu, Ningqun Wang and Liyong Wu
    Citation: Journal of Neuroinflammation 2023 20:65
  24. Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innat...

    Authors: Grégoire Stym-Popper, Karen Matta, Thomas Chaigneau, Roshan Rupra, Alexandros Demetriou, Stéphane Fouquet, Cira Dansokho, Cécile Toly-Ndour and Guillaume Dorothée
    Citation: Journal of Neuroinflammation 2023 20:64
  25. Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely unexplored. In this study, we characterized the molecular m...

    Authors: Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai and Junwei Hao
    Citation: Journal of Neuroinflammation 2023 20:63
  26. Although the advent of combination anti-retroviral therapy (cART) has transformed HIV into a manageable chronic disease, an estimated 30–50% of people living with HIV (PLWH) exhibit cognitive and motor deficit...

    Authors: Marina McDew-White, Eunhee Lee, Lakmini S. Premadasa, Xavier Alvarez, Chioma M. Okeoma and Mahesh Mohan
    Citation: Journal of Neuroinflammation 2023 20:62
  27. Zika virus (ZIKV) infection is a global public health concern linked to adult neurological disorders and congenital diseases in newborns. Host lipid metabolism, including lipid droplet (LD) biogenesis, has bee...

    Authors: Suelen Silva Gomes Dias, Tamires Cunha-Fernandes, Luciana Souza-Moreira, Vinicius Cardoso Soares, Giselle Barbosa Lima, Isaclaudia G. Azevedo-Quintanilha, Julia Santos, Filipe Pereira-Dutra, Caroline Freitas, Patricia A. Reis, Stevens Kastrup Rehen, Fernando A. Bozza, Thiago M. Lopes Souza, Cecilia J. G. de Almeida and Patricia T. Bozza
    Citation: Journal of Neuroinflammation 2023 20:61
  28. Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the CNS, use microRNAs to rapidl...

    Authors: Macarena S. Aloi, Katherine E. Prater, Raymond E. A. Sánchez, Asad Beck, Jasmine L. Pathan, Stephanie Davidson, Angela Wilson, C. Dirk Keene, Horacio de la Iglesia, Suman Jayadev and Gwenn A. Garden
    Citation: Journal of Neuroinflammation 2023 20:60
  29. Chronic pelvic pain (CPP) is a common symptom of endometriosis. Women with endometriosis are also at a high risk of suffering from anxiety, depression, and other psychological disorders. Recent studies indicat...

    Authors: Shah Tauseef Bashir, Catherine R. Redden, Kishori Raj, Rachel B. Arcanjo, Sandra Stasiak, Quanxi Li, Andrew J. Steelman and Romana A. Nowak
    Citation: Journal of Neuroinflammation 2023 20:59
  30. Theiler’s murine encephalomyelitis virus (TMEV) is a single-stranded RNA virus that causes encephalitis followed by chronic demyelination in SJL mice and spontaneous seizures in C57BL/6 mice. Since earlier stu...

    Authors: Melanie Bühler, Dandan Li, Lin Li, Sandra Runft, Inken Waltl, Andreas Pavlou, Ulrich Kalinke, Malgorzata Ciurkiewicz, Jochen Huehn, Stefan Floess, Andreas Beineke, Wolfgang Baumgärtner and Ingo Gerhauser
    Citation: Journal of Neuroinflammation 2023 20:58
  31. Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood glucose can damage multiple organs,...

    Authors: María Vargas-Soria, Mónica García-Alloza and Miriam Corraliza-Gómez
    Citation: Journal of Neuroinflammation 2023 20:57
  32. Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of Parkinson’s disease (PD), even ...

    Authors: Daniel Torrente, Enming J. Su, Gerald P. Schielke, Mark Warnock, Kris Mann and Daniel A. Lawrence
    Citation: Journal of Neuroinflammation 2023 20:56
  33. Periodontitis is closely associated with the pathogenesis of Alzheimer’s disease (AD). Porphyromonas gingivalis (Pg), the keystone periodontal pathogen, has been reported in our recent study to cause immune-overr...

    Authors: Xiao Cheng, Li Chi, Tianqiong Lin, Fengyin Liang, Zhong Pei, Jianbo Sun and Wei Teng
    Citation: Journal of Neuroinflammation 2023 20:55
  34. Neuroinflammation has been suggested that affects the processing of depression. There is renewed interest in berberine owing to its anti-inflammatory effects. Herein, we investigated whether berberine attenuat...

    Authors: Zongshi Qin, Dong-Dong Shi, Wenqi Li, Dan Cheng, Ying-Dan Zhang, Sen Zhang, Bun Tsoi, Jia Zhao, Zhen Wang and Zhang-Jin Zhang
    Citation: Journal of Neuroinflammation 2023 20:54
  35. Despite considerable efforts, ischemic stroke (IS) remains a challenging clinical problem. Therefore, the discovery of effective therapeutic and targeted drugs based on the underlying molecular mechanism is cr...

    Authors: Yilin Li, Tao Jin, Naixin Liu, Junsong Wang, Zihan Qin, Saige Yin, Yingxuan Zhang, Zhe Fu, Yutong Wu, Yinglei Wang, Yixiang Liu, Meifeng Yang, Ailan Pang, Jun Sun, Ying Wang and Xinwang Yang
    Citation: Journal of Neuroinflammation 2023 20:53
  36. Chronic kidney disease (CKD) is increasingly recognized as a stroke risk factor, but its exact relationship with cerebrovascular disease is not well-understood. We investigated the development of cerebral smal...

    Authors: Chuo Fang, Wei Ling Lau, Jiahong Sun, Rudy Chang, Adrian Vallejo, Donghy Lee, Jihua Liu, Han Liu, Yu-Han Hung, Yitong Zhao, Annlia Paganini-Hill, Rachita K. Sumbria, David H. Cribbs and Mark Fisher
    Citation: Journal of Neuroinflammation 2023 20:51
  37. The repair of white matter injury is of significant importance for functional recovery after ischemic stroke, and the up-regulation of triggering receptors expressed on myeloid cells 2 (TREM2) after ischemic s...

    Authors: Jinghui Xu, Liying Zhang, Mingyue Li, Xiaofei He, Jing Luo, Rui Wu, Zhongqiu Hong, Haiqing Zheng and Xiquan Hu
    Citation: Journal of Neuroinflammation 2023 20:50
  38. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) engraftment is a promising therapy for acute ischemic stroke (AIS). However, the harsh ischemic microenvironment limits the therapeutic efficacy of ...

    Authors: Yuan Li, Jialu Huang, Jie Wang, Simin Xia, Hong Ran, Lenyu Gao, Chengjian Feng, Li Gui, Zhenhua Zhou and Jichao Yuan
    Citation: Journal of Neuroinflammation 2023 20:49
  39. Aging is associated with loss of circadian immune responses and circadian gene transcription in peripheral macrophages. Microglia, the resident macrophages of the brain, also show diurnal rhythmicity in regula...

    Authors: Chinyere Agbaegbu Iweka, Erica Seigneur, Amira Latif Hernandez, Sur Herrera Paredes, Mica Cabrera, Eran Blacher, Connie Tsai Pasternak, Frank M. Longo, Luis de Lecea and Katrin I. Andreasson
    Citation: Journal of Neuroinflammation 2023 20:48
  40. We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine FDG–PET alterations. Metabolic connectivity refers to...

    Authors: Johannes Gnörich, Anika Reifschneider, Karin Wind, Artem Zatcepin, Sebastian T. Kunte, Philipp Beumers, Laura M. Bartos, Thomas Wiedemann, Maximilian Grosch, Xianyuan Xiang, Maryam K. Fard, Francois Ruch, Georg Werner, Mara Koehler, Luna Slemann, Selina Hummel…
    Citation: Journal of Neuroinflammation 2023 20:47
  41. Neurological manifestations of autoimmune connective tissue diseases (CTD) are poorly understood and difficult to diagnose. We here aimed to address this shortcoming by studying immune cell compositions in CTD...

    Authors: Michael Heming, Louisa Müller-Miny, Leoni Rolfes, Andreas Schulte-Mecklenbeck, Tobias J. Brix, Julian Varghese, Marc Pawlitzki, Hermann Pavenstädt, Martin A. Kriegel, Catharina C. Gross, Heinz Wiendl and Gerd Meyer zu Hörste
    Citation: Journal of Neuroinflammation 2023 20:46
  42. Retinal fibrosis affects 40–70% of neovascular age-related macular degeneration patients. This study investigated the effect of ageing on subretinal fibrosis secondary to choroidal neovascularization and the m...

    Authors: Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen and Heping Xu
    Citation: Journal of Neuroinflammation 2023 20:45
  43. Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous studies demonstrate that inflammatory astrocy...

    Authors: Marlena Zyśk, Chiara Beretta, Luana Naia, Abdulkhalek Dakhel, Linnea Påvénius, Hjalmar Brismar, Maria Lindskog, Maria Ankarcrona and Anna Erlandsson
    Citation: Journal of Neuroinflammation 2023 20:43
  44. The mechanisms of cognitive impairments in Parkinson’s disease (PD) remain unknown. Accumulating evidence revealed that brain neuroinflammatory response mediated by microglial cells contributes to cognitive de...

    Authors: Liyan Hou, Jianing Liu, Fuqiang Sun, Ruixue Huang, Rui Chang, Zhengzheng Ruan, Ying Wang, Jie Zhao and Qingshan Wang
    Citation: Journal of Neuroinflammation 2023 20:42
  45. Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyroptosis is a form of pro-inflammatory and lytic cell death which has been observed i...

    Authors: Yao Wang, Dilinuer Sadike, Bo Huang, Ping Li, Qiao Wu, Na Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang and Minjie Xie
    Citation: Journal of Neuroinflammation 2023 20:41
  46. Circular RNAs (circRNAs) are highly enriched in the central nervous system and have been implicated in neurodegenerative diseases. However, whether and how circRNAs contribute to the pathological processes ind...

    Authors: Chunling Huang, Lulu Sun, Chenyang Xiao, Wenjun You, Li Sun, Siye Wang, Zhijun Zhang and Su Liu
    Citation: Journal of Neuroinflammation 2023 20:39

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