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  1. Lipopolysaccharide (LPS) is the outer membrane component of Gram-negative bacteria. LPS-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS and has been used as a b...

    Authors: Yujia Zhao, Douglas I. Walker, Christina M. Lill, Bastiaan R. Bloem, Sirwan K. L. Darweesh, Brismar Pinto-Pacheco, Brooklyn McNeil, Gary W. Miller, Alicia K. Heath, Myrthe Frissen, Dafina Petrova, Maria-Jose Sánchez, María-Dolores Chirlaque, Marcela Guevara, Maurizio Zibetti, Salvatore Panico…
    Citation: Journal of Neuroinflammation 2023 20:170
  2. Dementia is a prevalent non-motor manifestation among individuals with advanced Parkinson’s disease (PD). Glial fibrillary acidic protein (GFAP) is an inflammatory marker derived from astrocytes. Research has ...

    Authors: Tingting Liu, Hongzhou Zuo, Di Ma, Dan Song, Yuying Zhao and Oumei Cheng
    Citation: Journal of Neuroinflammation 2023 20:167
  3. Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome that can cause many complications, impacting patients’ quality of life. Behavioral and cognitive disorders have attracted increasing...

    Authors: Hong Zheng, Qihui Zhao, Jianuo Chen, Jiahui Lu, Yuping Li and Hongchang Gao
    Citation: Journal of Neuroinflammation 2023 20:166
  4. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR autoantibody through the blood–brain barrier (BBB) is essential for pathogene...

    Authors: Yaqing Shu, Fuhua Peng, Bingchu Zhao, Chunxin Liu, Qihui Li, Huilu Li, Yuge Wang, Yanjun Jiang, Tingting Lu, Qin Wang, Jian Sun, Huiyu Feng, Zhengqi Lu, Xiaodong Liu, Jie Wang and Wei Qiu
    Citation: Journal of Neuroinflammation 2023 20:164
  5. Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, ...

    Authors: Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander…
    Citation: Journal of Neuroinflammation 2023 20:163
  6. Perioperative neurocognitive disorders (PND), such as delirium and cognitive impairment, are commonly encountered complications in aged patients. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is a...

    Authors: Lu-Ying Wang, Xu-Peng Wang, Jin-Meng Lv, Yu-Dong Shan, Shi-Yan Jia, Zhi-Fang Yu, Hui-Tao Miao, Yue Xin, Dong-Xue Zhang and Li-Min Zhang
    Citation: Journal of Neuroinflammation 2023 20:162
  7. Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acut...

    Authors: Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang and Fan-Gang Meng
    Citation: Journal of Neuroinflammation 2023 20:161
  8. In experimental stroke, ovariectomized (OVX) adult rats have larger infarct volumes and greater sensory-motor impairment as compared to ovary-intact females and is usually interpreted to indicate that ovarian ...

    Authors: Taylor E. Branyan, Jocelyn Aleksa, Esteban Lepe, Kelby Kosel and Farida Sohrabji
    Citation: Journal of Neuroinflammation 2023 20:159
  9. Inflammation is a fundamental biological response to injury and infection, which if unregulated can contribute to the pathophysiology of many diseases. The vagus nerve, which primarily originates from the dors...

    Authors: Nobuhide Kobori, Anthony N. Moore, John B. Redell and Pramod K. Dash
    Citation: Journal of Neuroinflammation 2023 20:158
  10. Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its re...

    Authors: Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu and Jian-Guo Chen
    Citation: Journal of Neuroinflammation 2023 20:157
  11. Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor cell-produced exosomes (EPC-EXOs) have been not...

    Authors: Feifei Yuan, Wei Peng, Yuying Yang, Jiaqi Xu, Yudong Liu, Yong Xie, Tingmo Huang, Chaoran Shi, Yinghe Ding, Chengjun Li, Tian Qin, Shanshan Xie, Fengzhang Zhu, Hongbin Lu, Jianjun Huang and Jianzhong Hu
    Citation: Journal of Neuroinflammation 2023 20:156
  12. Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal neurons, which causes disabling motor disorders. Scientific findings support the role of epigenetics mechanism in the...

    Authors: Deborah Mannino, Sarah Adriana Scuderi, Giovanna Casili, Valentina Bova, Laura Cucinotta, Marika Lanza, Alessia Filippone, Emanuela Esposito and Irene Paterniti
    Citation: Journal of Neuroinflammation 2023 20:155
  13. Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex cellular landscape comp...

    Authors: Joshua D. Samuels, Madison L. Lotstein, Michael L. Lehmann, Abdel G. Elkahloun, Subhadra Banerjee and Miles Herkenham
    Citation: Journal of Neuroinflammation 2023 20:154
  14. The existence of an interconnected mechanism between cognitive disorders and periodontitis has been confirmed by mounting evidence. However, the role of age or sex differences in this mechanism has been less s...

    Authors: Huiwen Chen, Yue Liao, Xu Zhang, Hui Shen, Dihua Shang, Zhiyan He, Wei Zhou and Zhongchen Song
    Citation: Journal of Neuroinflammation 2023 20:153
  15. Ambient RNAs contamination in single-nuclei RNA sequencing (snRNA-seq) is a challenging problem, but the consequences of ambient RNAs contamination of damaged and/or diseased tissues are poorly understood. Cog...

    Authors: Yuan Zhang, Jinyun Tan, Kai Yang, Weijian Fan, Bo Yu and Weihao Shi
    Citation: Journal of Neuroinflammation 2023 20:152
  16. Epilepsy is the second most prevalent neurological disease. Although there are many antiseizure drugs, approximately 30% of cases are refractory to treatment. Temporal lobe epilepsy (TLE) is the most common ep...

    Authors: Ya He, Hongxia Zhang, Limin Ma, Jingang Li, Fei Wang, Hui Zhou, Guangliang Zhang and Yuetao Wen
    Citation: Journal of Neuroinflammation 2023 20:151
  17. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious phenotype of systemic lupus erythematosus (SLE). The disturbance of neuron–microglia crosstalk is recently revealed in many neuropsychiatric d...

    Authors: Jingyi Xu, Chunshu Yang, Siyuan Zeng, Xuejiao Wang, Pingting Yang and Ling Qin
    Citation: Journal of Neuroinflammation 2023 20:150
  18. Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain state that occurs dose-dependently as a side effect and can limit or even impede an effective cancer therapy. Unfortunately, current t...

    Authors: Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger and Marco Sisignano
    Citation: Journal of Neuroinflammation 2023 20:149
  19. Neuroinflammation is a vital pathophysiological process during ischemic stroke. Activated astrocytes play a major role in inflammation. Lipocalin-2 (LCN2), secreted by activated astrocytes, promotes neuroinfla...

    Authors: Juanji Li, Pengfei Xu, Ye Hong, Yi Xie, Mengna Peng, Rui Sun, Hongquan Guo, Xiaohao Zhang, Wusheng Zhu, Junjun Wang and Xinfeng Liu
    Citation: Journal of Neuroinflammation 2023 20:148
  20. Parkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death of dopaminergic neurons induces an inflamm...

    Authors: Jesus Amo-Aparicio, Jonathan Daly, Jesper Falkesgaard Højen and Charles A. Dinarello
    Citation: Journal of Neuroinflammation 2023 20:147
  21. Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in astrocytes remains l...

    Authors: Xiaoxue Dong, Liqi Shu, Jinyu Zhang, Xu Yang, Xuejun Cheng, Xingsen Zhao, Wenzheng Qu, Qiang Zhu, Yikai Shou, Guoping Peng, Binggui Sun, Wen Yi, Qiang Shu and Xuekun Li
    Citation: Journal of Neuroinflammation 2023 20:146
  22. Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of...

    Authors: Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson and Przemyslaw Sapieha
    Citation: Journal of Neuroinflammation 2023 20:145
  23. Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease (AD) and is characterized by a complex etiology, high morbidity, and high rate of blindness. AU remission has been observed in pregnant ...

    Authors: Xiuxing Liu, Chenyang Gu, Jianjie Lv, Qi Jiang, Wen Ding, Zhaohao Huang, Yidan Liu, Yuhan Su, Chun Zhang, Zhuping Xu, Xianggui Wang and Wenru Su
    Citation: Journal of Neuroinflammation 2023 20:144
  24. Germinal matrix hemorrhage is a devastating disease of pre-term infancy commonly resulting in post-hemorrhagic hydrocephalus, periventricular leukomalacia, and subsequent neurocognitive deficits. We demonstrat...

    Authors: Devin Hatchell, Mohammed Alshareef, Tyler Vasas, Silvia Guglietta, Davis Borucki, Chunfang Guo, Khalil Mallah, Ramin Eskandari and Stephen Tomlinson
    Citation: Journal of Neuroinflammation 2023 20:143
  25. Microglial activation is critical for modulating the neuroinflammatory process and the pathological progression of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglia are involved in formin...

    Authors: Rawan Almarhoumi, Carla Alvarez, Theodore Harris, Christina M. Tognoni, Bruce J. Paster, Isabel Carreras, Alpaslan Dedeoglu and Alpdogan Kantarci
    Citation: Journal of Neuroinflammation 2023 20:142
  26. Trigeminal ganglia (TG) neurons are an important site of lifelong latent varicella-zoster virus (VZV) infection. Although VZV-specific T-cells are considered pivotal to control virus reactivation, their protec...

    Authors: Michiel van Gent, Werner J. D. Ouwendijk, Victoria L. Campbell, Kerry J. Laing, Georges M. G. M. Verjans and David M. Koelle
    Citation: Journal of Neuroinflammation 2023 20:141
  27. Zika virus (ZIKV) caused an outbreak in Brazil, in 2015, being associated to microcephaly. ZIKV has a strong neurotropism leading to death of infected cells in different brain regions, including the hippocampu...

    Authors: Marina da Silva Oliveira, Larissa Marcely Gomes Cassiano, Jeanne Pioline, Ketyllen Reis Andrade de Carvalho, Anna Christina de Matos Salim, Pedro Augusto Alves, Gabriel da Rocha Fernandes, Alexandre de Magalhães Vieira Machado and Roney Santos Coimbra
    Citation: Journal of Neuroinflammation 2023 20:140
  28. Autoimmune neuropathies can result in long-term disability and incomplete recovery, despite adequate first-line therapy. Kinesin-5 inhibition was shown to accelerate neurite outgrowth in different preclinical ...

    Authors: Felix Kohle, Robin Ackfeld, Franziska Hommen, Ines Klein, Martin K. R. Svačina, Christian Schneider, Gereon R. Fink, Mohammed Barham, David Vilchez and Helmar C. Lehmann
    Citation: Journal of Neuroinflammation 2023 20:139
  29. Multiple sclerosis (MS) leads to demyelination and neurodegeneration with autoimmune responses in central nervous system. Patients begin with a relapsing–remitting (RR) course, and more than 80% of them may ad...

    Authors: Ziyan Shi, Xiaofei Wang, Jiancheng Wang, Hongxi Chen, Qin Du, Yanlin Lang, Lingyao Kong, Wenqin Luo, Yuhan Qiu, Ying Zhang, Chen Li, Dingke Wen, Jie Yao, Xia Cheng, Linjun Cai, Xue Lin…
    Citation: Journal of Neuroinflammation 2023 20:138
  30. Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been associated with the pathogenesis of stress-induced hypertension (SIH). Neuronal mitochondrial dysfunction is involved in many pathological...

    Authors: Linping Wang, Tianfeng Liu, Xueping Wang, Lei Tong, Gaojun Chen, Shumin Zhou, Haili Zhang, Haisheng Liu, Wen Lu, Guohua Wang, Shuai Zhang and Dongshu Du
    Citation: Journal of Neuroinflammation 2023 20:137
  31. Multiple sclerosis (MS) is a chronic demyelinating autoimmune disorder which may cause long-term disability. MicroRNA (miRNA) are stable, non-coding molecules that have been identified in our Comprehensive Lon...

    Authors: Alicia Gonzalez-Martinez, Gauruv Bose, Hrishikesh Lokhande, Shrishti Saxena, Brian C. Healy, Mariann Polgar-Turcsanyi, Howard L. Weiner and Tanuja Chitnis
    Citation: Journal of Neuroinflammation 2023 20:136
  32. Gut microbiota plays a critical role in the regulation of immune homeostasis. Accordingly, several autoimmune disorders have been associated with dysbiosis in the gut microbiota. Notably, the dysbiosis associa...

    Authors: Carolina Prado, Alexandra Espinoza, J. Eduardo Martínez-Hernández, Joseph Petrosino, Erick Riquelme, Alberto J. M. Martin and Rodrigo Pacheco
    Citation: Journal of Neuroinflammation 2023 20:135
  33. Mutations in colony-stimulating factor 1 receptor (CSF1R) are known to cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which has been recently demonstrated as a primary m...

    Authors: Xin Li, Banglian Hu, Xiaoyan Guan, Ziwei Wang, Yuhang Zhou, Hao Sun, Xian Zhang, Yanfang Li, Xiaohua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhanxiang Wang and Honghua Zheng
    Citation: Journal of Neuroinflammation 2023 20:134
  34. Traumatic brain injury (TBI) remains a major cause of death and severe disability worldwide. We found previously that treatment with exogenous naïve B cells was associated with structural and functional neurop...

    Authors: Liam J. Dwyer, Saumya Maheshwari, Emily Levy, Mark C. Poznansky, Michael J. Whalen and Ruxandra F. Sîrbulescu
    Citation: Journal of Neuroinflammation 2023 20:133
  35. Microglia are tissue resident macrophages with a wide range of critically important functions in central nervous system development and homeostasis.

    Authors: Moein Yaqubi, Adam M. R. Groh, Marie-France Dorion, Elia Afanasiev, Julia Xiao Xuan Luo, Hadi Hashemi, Sarthak Sinha, Nicholas W. Kieran, Manon Blain, Qiao-Ling Cui, Jeff Biernaskie, Myriam Srour, Roy Dudley, Jeffery A. Hall, Joshua A. Sonnen, Nathalie Arbour…
    Citation: Journal of Neuroinflammation 2023 20:132
  36. Multiple sclerosis (MS) is a disabling autoimmune demyelinating disorder affecting young people and causing significant disability. In the last decade, different microRNA (miRNA) expression patterns have been ...

    Authors: Alicia Gonzalez-Martinez, Rohit Patel, Brian C. Healy, Hrishikesh Lokhande, Anu Paul, Shrishti Saxena, Mariann Polgar-Turcsanyi, Howard L. Weiner and Tanuja Chitnis
    Citation: Journal of Neuroinflammation 2023 20:131
  37. Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present. The interplay between hyperammonem...

    Authors: Wouter Claeys, Lien Van Hoecke, Hannah Lernout, Clint De Nolf, Griet Van Imschoot, Elien Van Wonterghem, Daan Verhaege, Jonas Castelein, Anja Geerts, Christophe Van Steenkiste and Roosmarijn E. Vandenbroucke
    Citation: Journal of Neuroinflammation 2023 20:130
  38. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by accumulation of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles, leading to chronic activation of...

    Authors: Megan J. Lantz, Alyssa M. Roberts, Donovan D. Delgado and Robert A. Nichols
    Citation: Journal of Neuroinflammation 2023 20:129
  39. Increasing evidence has connected the development of certain neuropsychiatric disorders, as well as neurodegenerative diseases, to stress-induced dysregulation of the immune system. We have shown that escapabl...

    Authors: Austin M. Adkins, Emily M. Colby, Woong-Ki Kim, Laurie L. Wellman and Larry D. Sanford
    Citation: Journal of Neuroinflammation 2023 20:128
  40. Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to respiratory infection are incompletely understood...

    Authors: Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash and Sarah Y. Yuan
    Citation: Journal of Neuroinflammation 2023 20:127
  41. The spinocerebellar ataxias (SCAs) are devastating neurological diseases characterized by progressive cerebellar incoordination. While neurons bear the brunt of the pathology, a growing body of evidence sugges...

    Authors: Chandrakanth Reddy Edamakanti, Vishwa Mohan and Puneet Opal
    Citation: Journal of Neuroinflammation 2023 20:126
  42. The meninges, membranes surrounding the central nervous system (CNS) boundary, harbor a diverse array of immunocompetent immune cells, and therefore, serve as an immunologically active site. Meningeal immunity...

    Authors: Yun Su, Huimin Zheng, Changhe Shi, Xinwei Li, Shuyu Zhang, Guangyu Guo, Wenkai Yu, Shuo Zhang, Zhengwei Hu, Jing Yang, Zongping Xia, Chengyuan Mao and Yuming Xu
    Citation: Journal of Neuroinflammation 2023 20:125
  43. Antenatal infection/inflammation is associated with disturbances in neuronal connectivity, impaired cortical growth and poor neurodevelopmental outcomes. The pathophysiological substrate that underpins these c...

    Authors: Sharmony B. Kelly, Justin M. Dean, Valerie A. Zahra, Ingrid Dudink, Alison Thiel, Graeme R. Polglase, Suzanne L. Miller, Stuart B. Hooper, Laura Bennet, Alistair J. Gunn and Robert Galinsky
    Citation: Journal of Neuroinflammation 2023 20:124
  44. The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoen...

    Authors: Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz and Britta Engelhardt
    Citation: Journal of Neuroinflammation 2023 20:123
  45. Autoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to affect the course of autoimmune diseases. Intestinal microorganisms ca...

    Authors: Yuting Meng, Xiangjie Qiu, Zhongxiang Tang, Yu Mao and Yurong Tan
    Citation: Journal of Neuroinflammation 2023 20:122
  46. Hepatic encephalopathy-induced hyperammonemia alters astrocytic glutamate metabolism in the brain, which is involved in cognitive decline. To identify specific therapeutic strategies for the treatment of hepat...

    Authors: Danbi Jo, Yeong-Hwan Lim, Yoon Seok Jung, Young-Kook Kim and Juhyun Song
    Citation: Journal of Neuroinflammation 2023 20:121
  47. Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal s...

    Authors: Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani and Jeremías G. Galletti
    Citation: Journal of Neuroinflammation 2023 20:120
  48. Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal do...

    Authors: Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li and Lili Gong
    Citation: Journal of Neuroinflammation 2023 20:119

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